YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: ERG11

General Information:
Name(s) found: ERG11 / YHR007C [SGD]
Description(s) found:
SHOW ONLY BEST
  • pir||A27491 lanosterol 14alpha-demethylase (EC 1.14.14.-) cytochrome P450 51 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6321795|ref|NP_011871.1| Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; Erg11p [Sacc [NCBI NR]
  • gi|500824|gb|AAB68433.1| Erg11p: Cytochrome P450 L1 (14DM) (Lanosterol 14-alpha demethylase) [Saccharomyces cerevisiae] [NCBI NR]
  • gi|170946|gb|AAA34379.1| 14-alpha-demethylase (14DM) [NCBI NR]
  • gi|117176|sp|P10614.1|CP51_YEAST RecName: Full=Lanosterol 14-alpha demethylase; AltName: Full=Cytochrome P450 51; AltName: Full=CYPLI; AltName: Full=P450-LIA1; AltName: Full=Sterol 14-alpha demethylase; AltName: Full=P450-14DM [NCBI NR]
  • Lanosterol 14-alpha demethylase OS=Saccharomyces cerevisiae GN=ERG11 PE=1 SV=1 [Swiss-Prot]
  • ERG11 Cytochrome P450 lanosterol 14a-demethylase [mips]
  • Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family [SGD]
  • ERG11, Chr VIII from 120084-121676, reverse complement [yeast_orfs2]
  • Chr VIII from 120084-121676, reverse complement [yeastorf3.fasta]
  • Chr VIII from 121676-120084, reverse complement [yeastorf5.fasta]
  • (P10614) Cytochrome P450 51 (EC 1.14.13.70) (CYPLI) (P450-LIA1) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (P450-14DM) [4932.FASTACCERV.txt]
  • ERG11 SGDID:S0001049, Chr VIII from 121677-120085, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Erg11p [Saccharomyces cerevisiae]gi|117176|sp|P10614|CP51_YEAST Cytochrome P450 51 (CYPLI) (P450-LIA1) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (P450-14DM)gi|82967|pir||A27491 lanosterol 14alpha-demethylase (EC 1.14.14.-) cytochro [nrdb_11152004_Chlamydomonas]
  • ERG11 SGDID:S000001049, Chr VIII from 121678-120086, reverse complement, Verified ORF, "Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Cytochrome P450 51 (CYPLI) (P450-LIA1) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (P450-14DM) [nr-271106-contam.fasta]
  • Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; Erg11p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 14-alpha-demethylase (14DM) [nr-271106-contam.fasta]
  • Erg11p: Cytochrome P450 L1 (14DM) (Lanosterol 14-alpha demethylase) [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ERG11 SGDID:S000001049, Chr VIII from 121678-120086, reverse complement, Verified ORF, "Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Lanosterol 14-alpha demethylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG11 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ERG11 SGDID:S000001049, Chr VIII from 121683-120091, Genome Release 64-1-1, reverse complement, Verified ORF, "Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p" [yeast-030211-contam.fasta]
  • ERG11 SGDID:S000001049, Chr VIII from 121683-120091, Genome Release 64-2-1, reverse complement, Verified ORF, "Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p" [20141208_orf_trans.fasta]
  • YHR007C SGDID:S000001049, Chr VIII from 121683-120091, Genome Release 64-1-1, reverse complement, Verified ORF, "Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 530 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article][TAS]
    Biological Process: ergosterol biosynthetic process [TAS]
    Molecular Function: sterol 14-demethylase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATKSIVGE ALEYVNIGLS HFLALPLAQR ISLIIIIPFI YNIVWQLLYS LRKDRPPLVF  60
   61 YWIPWVGSAV VYGMKPYEFF EECQKKYGDI FSFVLLGRVM TVYLGPKGHE FVFNAKLADV 120
  121 SAEAAYAHLT TPVFGKGVIY DCPNSRLMEQ KKFVKGALTK EAFKSYVPLI AEEVYKYFRD 180
  181 SKNFRLNERT TGTIDVMVTQ PEMTIFTASR SLLGKEMRAK LDTDFAYLYS DLDKGFTPIN 240
  241 FVFPNLPLEH YRKRDHAQKA ISGTYMSLIK ERRKNNDIQD RDLIDSLMKN STYKDGVKMT 300
  301 DQEIANLLIG VLMGGQHTSA ATSAWILLHL AERPDVQQEL YEEQMRVLDG GKKELTYDLL 360
  361 QEMPLLNQTI KETLRMHHPL HSLFRKVMKD MHVPNTSYVI PAGYHVLVSP GYTHLRDEYF 420
  421 PNAHQFNIHR WNKDSASSYS VGEEVDYGFG AISKGVSSPY LPFGGGRHRC IGEHFAYCQL 480
  481 GVLMSIFIRT LKWHYPEGKT VPPPDFTSMV TLPTGPAKII WEKRNPEQKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALD6 CCT8 CYS4 ERG11 ERR3 HSP150 SLD2 TUB2 WAR1
    View Details Qiu et al. (2008) ERG1 ERG11

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ERG11 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..157]
    [208..315]
    [381..410]    		 PSI-BLAST 555.9794 Cytochrome p450 14 alpha-sterol demethylase (cyp51)
    2 View Details [158..207]
    [316..380]
    [411..530]    		 PSI-BLAST 555.9794 Cytochrome p450 14 alpha-sterol demethylase (cyp51)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  5.03099580095037 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • oxygen binding
    		•  3.29945075872446 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.24344797738248 bayes_pls_golite062009
  • retinoic acid binding
    		•  3.04897926497756 bayes_pls_golite062009
  • arachidonic acid monooxygenase activity
    		•  3.03830845324387 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.41884363121524 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.29989218606587 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.09151585300316 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  1.65569090470706 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  1.4220050618113 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  1.04852693766796 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.03699542179837 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  0.918503562996019 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  0.33710488712754 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.22562022703652 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  0.169431271735966 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  0.167565425989292 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle