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Protein Overview: HUL5

General Information:
Name(s) found: HUL5 / YGL141W [SGD]
Description(s) found:
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  • gi|6321297|ref|NP_011374.1| Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability; Hul5p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51830331|gb|AAU09728.1| YGL141W [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S64155 hypothetical protein YGL141w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1723924|sp|P53119.1|HUL5_YEAST RecName: Full=Probable E3 ubiquitin-protein ligase HUL5 [NCBI NR]
  • gi|1498243|emb|CAA68221.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1322718|emb|CAA96853.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Probable E3 ubiquitin-protein ligase HUL5 OS=Saccharomyces cerevisiae GN=HUL5 PE=1 SV=1 [Swiss-Prot]
  • HUL5 Ubiquitin-protein ligase (E3) [mips]
  • Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of misfolded proteins into cytoplasm during ERAD [SGD]
  • HUL5, Chr VII from 238356-241088 [yeast_orfs2]
  • Chr VII from 238356-241088 [yeastorf3.fasta]
  • (P53119) Probable ubiquitin--protein ligase HUL5 (EC 6.3.2.-) [4932.FASTACCERV.txt]
  • HUL5 SGDID:S0003109, Chr VII from 238356-241088, Verified ORF [yeastflysequest.fasta]
  • HUL5 SGDID:S0003109, Chr VII from 238358-241090, Verified ORF [10112005cervSGD.fasta]
  • Hul5p [Saccharomyces cerevisiae]gi|51830331|gb|AAU09728.1| YGL141W [Saccharomyces cerevisiae]gi|1322718|emb|CAA96853.1| unnamed protein product [Saccharomyces cerevisiae]gi|1498243|emb|CAA68221.1| unnamed protein product [Saccharomyces cerevisiae]gi|2 [nrdb_11152004_Chlamydomonas]
  • HUL5 SGDID:S000003109, Chr VII from 238358-241090, Verified ORF, "Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • HUL5 SGDID:S000003109, Chr VII from 238358-241090, Verified ORF, "Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability; Hul5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Probable ubiquitin-protein ligase HUL5 [nr-271106-contam.fasta]
  • YGL141W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • HUL5 SGDID:S000003109, Chr VII from 238358-241090, Verified ORF, "Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of misfolded proteins into cytoplasm during ERAD" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Probable E3 ubiquitin-protein ligase HUL5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HUL5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HUL5 SGDID:S000003109, Chr VII from 238353-241085, Genome Release 64-1-1, Verified ORF, "Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD" [yeast-030211-contam.fasta]
  • HUL5 SGDID:S000003109, Chr VII from 238353-241085, Genome Release 64-2-1, Verified ORF, "Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD" [20141208_orf_trans.fasta]
  • YGL141W SGDID:S000003109, Chr VII from 238353-241085, Genome Release 64-1-1, Verified ORF, "Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 910 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: protein polyubiquitination [TASLink to PubMed article]
    protein monoubiquitination [TASLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNFTGQTRR RNVNLGNRTR NSKKDLLEKA KRERERRAQD KLKEDASKTI QKSIRRHFSN  60
   61 VRLFKNTFTS SQLVHMIPAY GGKLIYYISQ YDLQQLLKLS HNFLSSYPNS LGNRQLLSLL 120
  121 KLYQDDALVA ETLSDLNMDC PTVDEFLDSL SVYLCRASFL SYSSASKLAD VIEAWEVMHS 180
  181 SASISIFSIS IGSYEKRPFA LQFYCILAER NLLPQLINTN PILWDNMAKT YSHCSKGGQK 240
  241 NIAKLLIPNF NNHIAPSVLR SDNDYVLKFY EKAFIDEVIA TTANYVSDED HVKNLMCYIA 300
  301 SSPNQSCKNS VLITLLSNKD FVRRLSWEFF HTKFNASKTE AHPLFSVLAQ LIDMHLLIST 360
  361 DRELLDYNSV IPIEELKKFT STLKDFTFRQ YWELPKSERN PMLKEAVPLL SKVYERDSRL 420
  421 HFLSTENNPT YWENSEKQFL NLRFYEELQE YEDLYREHLE EESDEDMEKE IDLDKERPPL 480
  481 KSLLLNKMKK RLKSSLRFRK LEILLELPFF IPFEERVDLF YMFIALDKKR LSLDDDHNLI 540
  541 NMFTPWASTG MRKQSAIISR DNVLEDAFNA FNSIGERFKA SLDVTFINEF GEEAGIDGGG 600
  601 ITKEFLTTVS DEGFKDPKHE LFRTNDRYEL YPSVVYDATK LKYIWFLGKV VGKCLYEHVL 660
  661 IDVSFADFFL KKLLNYSNGF LSSFSDLGSY DSVLYNNLIK LLNMTTDEIK SLDLTFEIDE 720
  721 PESSAKVVDL IPNGSKTYVT KDNVLLYVTK VTDYKLNKRC FKPVSAFHGG LSVIIAPHWM 780
  781 EMFNSIELQM LISGERDNID LDDLKSNTEY GGYKEEDQTI VDFWEVLNEF KFEEKLNFLK 840
  841 FVTSVPQAPL QGFKALDPKF GIRNAGTEKY RLPTASTCVN LLKLPDYRNK TILREKLLYA 900
  901 INSGARFDLS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Ho Y, et al. (2002) CMD1 CMP2 ERB1 HUL5 MAK11 MLC1 MYO2 MYO3 MYO4 MYO5 NOP2 NOP7 SHE4 SPC110 TIF6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HUL5 YGR053C 2 Unpublished Fields Lab Data
    View Screen HUL5 PET494 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HUL5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..323] deduced N/A No confident structure predictions are available.
    2 View Details [324..458] MSA 1.04399 View MSA. Confident ab initio structure predictions are available.
    3 View Details [459..549] deduced N/A No confident structure predictions are available.
    4 View Details [550..596] PSI-BLAST 504.228787 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
    5 View Details [597..695]
    [752..794]    		 PSI-BLAST 504.228787 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
    6 View Details [696..751]
    [795..910]    		 PSI-BLAST 504.228787 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle