Protein Overview: ALG2

General Information:
Name(s) found:	ALG2 / YGL065C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321373\|ref\|NP_011450.1\| Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; [NCBI NR] pir\|\|S64069 ALG2 protein precursor - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1703249\|sp\|P43636.2\|ALG2_YEAST RecName: Full=Alpha-1,3-mannosyltransferase ALG2; AltName: Full=GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; AltName: Full=Asparagine-linked glycosylation protein 2 [NCBI NR] gi\|1322572\|emb\|CAA96768.1\| ALG2 [Saccharomyces cerevisiae] [NCBI NR] Alpha-1,3-mannosyltransferase ALG2 OS=Saccharomyces cerevisiae GN=ALG2 PE=1 SV=2 [Swiss-Prot] ALG2 Mannosyltransferase [mips] Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol [SGD] ALG2, Chr VII from 379758-381269, reverse complement [yeast_orfs2] Chr VII from 379758-381269, reverse complement [yeastorf3.fasta] Chr VII from 379761-381272, reverse complement [yeastorf4.fasta] Chr VII from 381272-379761, reverse complement [yeastorf5.fasta] (P43636) Glycosyltransferase ALG2 (EC 2.4.1.-) [4932.FASTACCERV.txt] ALG2 SGDID:S0003033, Chr VII from 381272-379761, reverse complement, Verified ORF [yeastflysequest.fasta] ALG2 SGDID:S0003033, Chr VII from 381274-379763, reverse complement, Verified ORF [10112005cervSGD.fasta] Alg2p [Saccharomyces cerevisiae]gi\|1322572\|emb\|CAA96768.1\| ALG2 [Saccharomyces cerevisiae]gi\|2131170\|pir\|\|S64069 ALG2 protein precursor - yeast (Saccharomyces cerevisiae)gi\|1703249\|sp\|P43636\|ALG2_YEAST Alpha-1,3-mannosyltransferase ALG2 (GDP-Man:Man(1) [nrdb_11152004_Chlamydomonas] (P43636) Alpha-1,3-mannosyltransferase ALG2 (EC 2.4.1.-) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) [cerv4932.FASTAC] ALG2 SGDID:S000003033, Chr VII from 381274-379763, reverse complement, Verified ORF, "Presumed early mannosyltransferase involved in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lip [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ALG2 SGDID:S000003033, Chr VII from 381274-379763, reverse complement, Verified ORF, "Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulati [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] ALG2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Alpha-1,3-mannosyltransferase ALG2 (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (Asparagine-linked glycosylation protein 2) [nr-271106-contam.fasta] Presumed early mannosyltransferase involved in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; Alg2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ALG2 SGDID:S000003033, Chr VII from 381274-379763, reverse complement, Verified ORF, "Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol" [yeast-bovrabprots.fasta] ALG2 SGDID:S000003033, Chr VII from 381274-379763, reverse complement, Verified ORF, "Presumed early mannosyltransferase involved in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol" [yeast-contam_custom.fasta] [chemostatdb.fasta] Alpha-1,3/1,6-mannosyltransferase ALG2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ALG2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ALG2 SGDID:S000003033, Chr VII from 381271-379760, Genome Release 64-1-1, reverse complement, Verified ORF, "Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol" [yeast-030211-contam.fasta] ALG2 SGDID:S000003033, Chr VII from 381271-379760, Genome Release 64-2-1, reverse complement, Verified ORF, "Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol" [20141208_orf_trans.fasta] YGL065C SGDID:S000003033, Chr VII from 381271-379760, Genome Release 64-1-1, reverse complement, Verified ORF, "Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	503 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum [TAS]
Biological Process:	oligosaccharide-lipid intermediate assembly [TAS]
Molecular Function:	glycolipid mannosyltransferase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIEKDKRTIA FIHPDLGIGG AERLVVDAAL GLQQQGHSVI IYTSHCDKSH CFEEVKNGQL  60
   61 KVEVYGDFLP TNFLGRFFIV FATIRQLYLV IQLILQKKVN AYQLIIIDQL STCIPLLHIF 120
  121 SSATLMFYCH FPDQLLAQRA GLLKKIYRLP FDLIEQFSVS AADTVVVNSN FTKNTFHQTF 180
  181 KYLSNDPDVI YPCVDLSTIE IEDIDKKFFK TVFNEGDRFY LSINRFEKKK DVALAIKAFA 240
  241 LSEDQINDNV KLVICGGYDE RVAENVEYLK ELQSLADEYE LSHTTIYYQE IKRVSDLESF 300
  301 KTNNSKIIFL TSISSSLKEL LLERTEMLLY TPAYEHFGIV PLEAMKLGKP VLAVNNGGPL 360
  361 ETIKSYVAGE NESSATGWLK PAVPIQWATA IDESRKILQN GSVNFERNGP LRVKKYFSRE 420
  421 AMTQSFEENV EKVIWKEKKY YPWEIFGISF SNFILHMAFI KILPNNPWPF LFMATFMVLY 480
  481 FKNYLWGIYW AFVFALSYPY EEI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		ALG1 ALG13 ALG2 ALG8 ALG9 OST1 PMT1 PMT3 PMT4 STT3 WBP1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	ALG2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..127] [419..503]	ORFEUS	10.52	UDP-glucosyltransferase GtfB
2	View Details	[128..198] [414..418]	ORFEUS	10.52	UDP-glucosyltransferase GtfB
3	View Details	[199..413]	ORFEUS	10.52	UDP-glucosyltransferase GtfB

Protein Overview: ALG2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: