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Protein Overview: ATG18

General Information:
Name(s) found: ATG18 / YFR021W [SGD]
Description(s) found:
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  • gi|836776|dbj|BAA09260.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|16740527|ref|NP_444297.1| Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 [NCBI NR]
  • gi|1176002|sp|P43601.1|ATG18_YEAST RecName: Full=Autophagy-related protein 18; AltName: Full=Cytoplasm to vacuole targeting protein 18; AltName: Full=Swollen vacuole phenotype protein 1; AltName: Full=Needed for premeiotic replication protein 1 [NCBI NR]
  • pir||S56276 probable membrane protein YFR021w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • (P43601) Hypothetical WD-repeats containing protein YFR021w [Swiss-Prot]
  • Autophagy-related protein 18 OS=Saccharomyces cerevisiae GN=ATG18 PE=1 SV=1 [Swiss-Prot]
  • ATG18 Phosphatidylinositol 3,5-bisphosphate-binding protein recycles Atg9p through the pre-autophagosomal structure [mips]
  • Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein [SGD]
  • NMR1, Chr VI from 194799-196301 [yeast_orfs2]
  • Chr VI from 194799-196301 [yeastorf3.fasta]
  • Chr VI from 194800-196302 [yeastorf5.fasta]
  • (P43601) Hypothetical 55.1 kDa Trp-Asp repeats containing protein in FAB1-PES4 intergenic region [4932.FASTACCERV.txt]
  • ATG18 SGDID:S0001917, Chr VI from 194800-196302, Verified ORF [yeastflysequest.fasta]
  • Atg18p [Saccharomyces cerevisiae]gi|1176002|sp|P43601|YFJ1_YEAST Hypothetical WD-repeats containing protein YFR021wgi|1084743|pir||S56276 probable membrane protein YFR021w - yeast (Saccharomyces cerevisiae)gi|836776|dbj|BAA09260.1| YFR021W [Saccharomyc [nrdb_11152004_Chlamydomonas]
  • ATG18 SGDID:S000001917, Chr VI from 194800-196302, Verified ORF, "Phosphatidylinositol 3,5-bisphosphate-binding protein of the vacuolar membrane, predicted to fold as a seven-bladed beta-propeller; required for recycling of Atg9p through the pre-autophago [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ATG18 SGDID:S000001917, Chr VI from 194800-196302, Verified ORF, "Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and pho [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Phosphatidylinositol 3,5-bisphosphate-binding protein of the vacuolar membrane, predicted to fold as a seven-bladed beta-propeller; required for recycling of Atg9p through the pre-autophagosomal structure; Atg18p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Autophagy-related protein 18 (Cytoplasm to vacuole targeting protein 18) (Swollen vacuole phenotype protein 1) (Needed for premeiotic replication protein 1) [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ATG18 SGDID:S000001917, Chr VI from 194800-196302, Verified ORF, "Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein" [yeast-bovrabprots.fasta]
  • ATG18 SGDID:S000001917, Chr VI from 194800-196302, Verified ORF, "Phosphatidylinositol 3,5-bisphosphate-binding protein of the vacuolar membrane, predicted to fold as a seven-bladed beta-propeller; required for recycling of Atg9p through the pre-autophagosomal structure" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Autophagy-related protein 18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG18 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ATG18 SGDID:S000001917, Chr VI from 194812-196314, Genome Release 64-1-1, Verified ORF, "Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein" [yeast-030211-contam.fasta]
  • ATG18 SGDID:S000001917, Chr VI from 194812-196314, Genome Release 64-2-1, Verified ORF, "Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood" [20141208_orf_trans.fasta]
  • YFR021W SGDID:S000001917, Chr VI from 194812-196314, Genome Release 64-1-1, Verified ORF, "Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 500 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: ascospore formation [IMPLink to PubMed article]
    vacuolar protein processing [IDALink to PubMed article][IMPLink to PubMed article]
    vacuole organization [IMPLink to PubMed article]
    autophagy [IDALink to PubMed article][IMPLink to PubMed article]
    CVT pathway [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: phosphoinositide binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSSPTINF INFNQTGTCI SLGTSKGFKI FNCEPFGKFY SEDSGGYAIV EMLFSTSLLA  60
   61 LVGIGDQPAL SPRRLRIINT KKHSIICEVT FPTSILSVKM NKSRLVVLLQ EQIYIYDINT 120
  121 MRLLHTIETN PNPRGLMAMS PSVANSYLVY PSPPKVINSE IKAHATTNNI TLSVGGNTET 180
  181 SFKRDQQDAG HSDISDLDQY SSFTKRDDAD PTSSNGGNSS IIKNGDVIVF NLETLQPTMV 240
  241 IEAHKGEIAA MAISFDGTLM ATASDKGTII RVFDIETGDK IYQFRRGTYA TRIYSISFSE 300
  301 DSQYLAVTGS SKTVHIFKLG HSMSNNKLDS DDSNMEEAAA DDSSLDTTSI DALSDEENPT 360
  361 RLAREPYVDA SRKTMGRMIR YSSQKLSRRA ARTLGQIFPI KVTSLLESSR HFASLKLPVE 420
  421 TNSHVMTISS IGSPIDIDTS EYPELFETGN SASTESYHEP VMKMVPIRVV SSDGYLYNFV 480
  481 MDPERGGDCL ILSQYSILMD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATG18 ATG2 SAP155
    View Details Krogan NJ, et al. (2006) ATG18 TRM5
    View Details Gavin AC, et al. (2002) ADH1 ATG18 ATG2
    View Details Ho Y, et al. (2002) ATG18 ATG2 CDC55 SAP155 SIT4 THI21 UTP13
    View Details Qiu et al. (2008) ATG18 ATG21

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ATG18 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] MSA 6.502996 View MSA. Confident ab initio structure predictions are available.
    2 View Details [80..131] PSI-BLAST 64.69897 beta1-subunit of the signal-transducing G protein heterotrimer
    3 View Details [132..500] PSI-BLAST 62.69897 Tup1, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.8484919978091 bayes_pls_golite062009
  • protein binding
    		•  1.42618832381942 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.624115832843391 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.479978536094414 bayes_pls_golite062009
  • hydrolase activity
    		•  0.36638536879917 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.359536347486199 bayes_pls_golite062009
  • signal transducer activity
    		•  0.343972561304413 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.343972561304413 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.282387003961579 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.67

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle