Protein Overview: PAB1

General Information:
Name(s) found:	PAB1 / YER165W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321013\|ref\|NP_011092.1\| Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor [NCBI NR] gi\|603406\|gb\|AAB64692.1\| Pab1p: polyadenylate-binding protein [Saccharomyces cerevisiae] [NCBI NR] gi\|51013159\|gb\|AAT92873.1\| YER165W [Saccharomyces cerevisiae] [NCBI NR] gi\|417441\|sp\|P04147.4\|PABP_YEAST RecName: Full=Polyadenylate-binding protein, cytoplasmic and nuclear; Short=Poly(A)-binding protein; Short=PABP; AltName: Full=ARS consensus-binding protein ACBP-67; AltName: Full=Polyadenylate tail-binding protein [NCBI NR] gi\|218386\|dbj\|BAA00017.1\| polyadenylate-binding protein [Saccharomyces cerevisiae] [NCBI NR] gi\|171967\|gb\|AAA34787.1\| poly (A)-binding protein [NCBI NR] pir\|\|DNBYPA polyadenylate-binding protein - yeast (Saccharomyces cerevisiae) [NCBI NR] Polyadenylate-binding protein, cytoplasmic and nuclear OS=Saccharomyces cerevisiae GN=PAB1 PE=1 SV=4 [Swiss-Prot] PAB1 mRNA polyadenylate-binding protein [mips] Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G [SGD] PAB1, Chr V from 510368-512101 [yeast_orfs2] Chr V from 510368-512101 [yeastorf3.fasta] PAB1 SGDID:S0000967, Chr V from 510368-512101, Verified ORF [yeastflysequest.fasta] Pab1p [Saccharomyces cerevisiae]gi\|51013159\|gb\|AAT92873.1\| YER165W [Saccharomyces cerevisiae]gi\|1070599\|pir\|\|DNBYPA polyadenylate-binding protein - yeast (Saccharomyces cerevisiae)gi\|603406\|gb\|AAB64692.1\| Pab1p: polyadenylate-binding protein [Saccharom [nrdb_11152004_Chlamydomonas] PAB1 SGDID:S000000967, Chr V from 510368-512101, Verified ORF, "Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Polyadenylate-binding protein, cytoplasmic and nuclear (Poly(A)-binding protein) (PABP) (ARS consensus-binding protein ACBP-67) (Polyadenylate tail-binding protein) [nr-271106-contam.fasta] YER165W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; Pab1p [Saccharomyces [nr-271106-contam.fasta] poly (A)-binding protein [nr-271106-contam.fasta] Pab1p: polyadenylate-binding protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] polyadenylate-binding protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] PAB1 SGDID:S000000967, Chr V from 510368-512101, Verified ORF, "Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Polyadenylate-binding protein, cytoplasmic and nuclear OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAB1 PE=1 SV=4 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PAB1 SGDID:S000000967, Chr V from 510373-512106, Genome Release 64-1-1, Verified ORF, "Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G" [yeast-030211-contam.fasta] PAB1 SGDID:S000000967, Chr V from 510373-512106, Genome Release 64-2-1, Verified ORF, "Poly(A) binding protein; part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; stimulates, but is not required for the deadenylation activity of the Pan2p-Pan3p poly(A)-ribonuclease complex" [20141208_orf_trans.fasta] TR6155\|c0_g1_i1\|g.4372 ORF TR6155\|c0_g1_i1\|g.4372 TR6155\|c0_g1_i1\|m.4372 type:complete len:578 (+) TR6155\|c0_g1_i1:150-1883(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YER165W SGDID:S000000967, Chr V from 510373-512106, Genome Release 64-1-1, Verified ORF, "Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_7665\|g.5528 ORF asmbl_7665\|g.5528 asmbl_7665\|m.5528 type:complete len:578 (+) asmbl_7665:142-1875(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_7643\|g.4857 ORF ID=asmbl_7643\|g.4857 ID=asmbl_7643\|m.4857 type:complete len:578 (+) ID=asmbl_7643:142-1875(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	577 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA] ribosome [IDA]
Biological Process:	regulation of translational initiation [IDA][IMP]
Molecular Function:	poly(A) RNA binding [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADITDKTAE QLENLNIQDD QKQAATGSES QSVENSSASL YVGDLEPSVS EAHLYDIFSP  60
   61 IGSVSSIRVC RDAITKTSLG YAYVNFNDHE AGRKAIEQLN YTPIKGRLCR IMWSQRDPSL 120
  121 RKKGSGNIFI KNLHPDIDNK ALYDTFSVFG DILSSKIATD ENGKSKGFGF VHFEEEGAAK 180
  181 EAIDALNGML LNGQEIYVAP HLSRKERDSQ LEETKAHYTN LYVKNINSET TDEQFQELFA 240
  241 KFGPIVSASL EKDADGKLKG FGFVNYEKHE DAVKAVEALN DSELNGEKLY VGRAQKKNER 300
  301 MHVLKKQYEA YRLEKMAKYQ GVNLFVKNLD DSVDDEKLEE EFAPYGTITS AKVMRTENGK 360
  361 SKGFGFVCFS TPEEATKAIT EKNQQIVAGK PLYVAIAQRK DVRRSQLAQQ IQARNQMRYQ 420
  421 QATAAAAAAA AGMPGQFMPP MFYGVMPPRG VPFNGPNPQQ MNPMGGMPKN GMPPQFRNGP 480
  481 VYGVPPQGGF PRNANDNNQF YQQKQRQALG EQLYKKVSAK TSNEEAAGKI TGMILDLPPQ 540
  541 EVFPLLESDE LFEQHYKEAS AAYESFKKEQ EQQTEQA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		CDC33 PAB1 TIF4631
View Details	Gavin AC, et al. (2006)		BOI1 NAB6 PAB1 PAN2 YGR250C
View Details	Ho Y, et al. (2002)		ACS2 ADE3 ADE6 ADO1 ALA1 APE2 APL2 APL4 APM1 ARA1 BAT1 BRX1 CDC10 CIC1 CLU1 CYS3 DED81 DPS1 ERG10 ERG20 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KRI1 KRR1 KRS1 LSP1 MDH3 NMA1 NOG1 NOP4 OLA1 PAB1 PFK2 PGM2 PMI40 PRP6 PWP1 RCL1 SAC6 SCP160 SOD1 SSZ1 THR4 TIF6 TRR1 TUF1 UBA1 YDL124W
View Details	Qiu et al. (2008)		PAB1 PRP2 PRP43

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	TOR1	No Comments	Reinke A, et al. (2004)
View Run	HSL7	No Comments	McCusker D, et al (2007)
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	LST8	No Comments	Reinke A, et al. (2004)
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	SEC10	No Comments	De Craene, J., et al. (2006)
View Run	DAD1	Dam1 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	MIH1	control 1	McCusker D, et al (2007)
View Run	RLF2	cac1: TAP-tagged	Green EM, et al (2005)
View Run	DAD1	Dam1-765 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	DAD1	Dam1 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	VAM3	Sample: HX14 - mixture in detergent (control).	Hao Xu, et al. (2010)
View Run	MLP2	#19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#19b Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#19a Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	PAB1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..116]	PSI-BLAST	653.927757	Poly(A)-binding protein
2	View Details	[117..215]	PSI-BLAST	653.927757	Poly(A)-binding protein
3	View Details	[216..307]	PSI-BLAST	128.31133	Nuclear ribonucleoprotein A1 (RNP A1, UP1)
4	View Details	[308..432]	PSI-BLAST	128.31133	Nuclear ribonucleoprotein A1 (RNP A1, UP1)
5	View Details	[433..485]	deduced	N/A	No confident structure predictions are available.
6	View Details	[486..577]	PSI-BLAST	390.67837	poly(A) binding protein

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.86

Protein Overview: PAB1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: