Protein Overview: SEC1

General Information:
Name(s) found:	SEC1 / YDR164C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|899411\|emb\|CAA90384.1\| Sec1p [Saccharomyces cerevisiae] [NCBI NR] gi\|6320368\|ref\|NP_010448.1\| Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; Sec1p [ [NCBI NR] gi\|4431\|emb\|CAA44308.1\| Sec1 protein [Saccharomyces cerevisiae] [NCBI NR] gi\|266998\|sp\|P30619.1\|SEC1_YEAST RecName: Full=Protein transport protein SEC1 [NCBI NR] pir\|\|S17479 SEC1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] Protein transport protein SEC1 OS=Saccharomyces cerevisiae GN=SEC1 PE=1 SV=1 [Swiss-Prot] SEC1 Protein transport protein [mips] Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function [SGD] SEC1, Chr IV from 782034-784208, reverse complement [yeast_orfs2] Chr IV from 782034-784208, reverse complement [yeastorf3.fasta] Chr IV from 784208-782034, reverse complement [yeastorf5.fasta] (P30619) Protein transport protein SEC1 [4932.FASTACCERV.txt] SEC1 SGDID:S0002571, Chr IV from 784209-782035, reverse complement, Verified ORF [yeastflysequest.fasta] SEC1 SGDID:S0002571, Chr IV from 784210-782036, reverse complement, Verified ORF [10112005cervSGD.fasta] Sec1p [Saccharomyces cerevisiae]gi\|4431\|emb\|CAA44308.1\| Sec1 protein [Saccharomyces cerevisiae]gi\|899411\|emb\|CAA90384.1\| Sec1p [Saccharomyces cerevisiae]gi\|266998\|sp\|P30619\|SEC1_YEAST Protein transport protein SEC1gi\|101613\|pir\|\|S17479 SEC1 protein - [nrdb_11152004_Chlamydomonas] SEC1 SGDID:S000002571, Chr IV from 784210-782036, reverse complement, Verified ORF, "Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] SEC1 SGDID:S000002571, Chr IV from 784212-782038, reverse complement, Verified ORF, "Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud [yeast-contam.fasta] SEC1 SGDID:S000002571, Chr IV from 784213-782039, reverse complement, Verified ORF, "Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Sec1 protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein transport protein SEC1 [nr-271106-contam.fasta] Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; Sec1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Sec1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SEC1 SGDID:S000002571, Chr IV from 784213-782039, reverse complement, Verified ORF, "Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function" [yeast-bovrabprots.fasta] SEC1 SGDID:S000002571, Chr IV from 784212-782038, reverse complement, Verified ORF, "Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function" [yeast-contam_custom.fasta] [chemostatdb.fasta] Protein transport protein SEC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SEC1 SGDID:S000002571, Chr IV from 784215-782041, Genome Release 64-1-1, reverse complement, Verified ORF, "Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function" [yeast-030211-contam.fasta] SEC1 SGDID:S000002571, Chr IV from 784215-782041, Genome Release 64-2-1, reverse complement, Verified ORF, "Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p" [20141208_orf_trans.fasta] YDR164C SGDID:S000002571, Chr IV from 784215-782041, Genome Release 64-1-1, reverse complement, Verified ORF, "Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_873\|g.366 ORF ID=asmbl_873\|g.366 ID=asmbl_873\|m.366 type:complete len:725 (+) ID=asmbl_873:495-2669(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	724 amino acids
Gene Ontology:
Cellular Component:	cellular bud tip [IDA ] cellular bud neck [IDA ] plasma membrane [IDA]
Biological Process:	vesicle fusion [IDA][IMP] vesicle docking during exocytosis [IPI] exocytosis [IMP][IPI]
Molecular Function:	SNARE binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLIELQRN YLIGVLNQIE TKNNLKFLII DKTVETILSY LFLTPQELLN NVTSVDLIDS  60
   61 PTRKGQSSIE AIYILEPTKY NINCIDADFM VRPPKYRRCH IRFLPGLTNP IFQFFQSKRY 120
  121 IAQNLESFKP IELGFFVKES QFFETLQMEH SLQVFFNNNC KALIPTNVRK IVGSLVSLCV 180
  181 ITGEYPIVRY SVSNPVEEED ARNGNAVVNA NSLTRSIANA FQIAIDTYAR NNPDFPPQNT 240
  241 ERPRSILIIT DRTLDPFAPI LHDFSYQAMA YDLVANVDTQ KDIYHYSAEN EAGEQEEKVS 300
  301 KLVDLYDPDW IDLKHQHIMD ANEYIQGRIK ELIAKNPLLV DRSNVKNTTD LLSVVAHLKD 360
  361 FDEERRRLIL HKTLVDECLG ENAERKLADI SAIEQNLSGF GMDFSGEKIK HIIDDLLPAL 420
  421 AMKEPTILDK LRYIIAYALF RGGIIELDFI KLLNFIGVTH EHENFQQYLK IFRNYDLIDF 480
  481 KLIKDKPKDK PFQKEWFHDT LVNDPNIYHT SRFVPAVGNI LSKVIANPLL LSEQYFPYLK 540
  541 DKPIELLNEE EFQAGLANTS ANSSSSLRNP RHKAAWTTKS SNIKKNIPRQ RFFYYVIGGI 600
  601 SIPEIKAAYD QSNLKNRDIF IGSDEILTPT KFLDEVERLQ NPREFFKFKE DQRQQVNPPD 660
  661 FLLREMKPVA QPVSHVHLKS QDNSPKSGTS SPKAAGSLKS EPPEKEKKRS KFSRFLKRKS 720
  721 HHDK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		SEC1 SEC13 SEC31
View Details	Gavin AC, et al. (2006)		BUD3 PGI1 SEC1
View Details	Gavin AC, et al. (2002)		ADH1 ATG26 BEM2 BUD3 COP1 CYR1 HRR25 IMG1 IMG2 IML1 MHR1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 NUG1 PGI1 PRP43 RET2 ROM2 RTC6 SEC1 SEC26 SEC27 SIN4 SNF2 SWI3 SYP1 TAF5 UTP20 YDR115W YML6
View Details	Qiu et al. (2008)		GYL1 SEC1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NAF1	No Comments	Hazbun TR, et al. (2003)
View Run	BOI1	Sample bob1 (2nd set) from october 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SGS1	SEC1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SEC1	Huh WK, et al. (2003)
View Data	SEC1	Huh WK, et al. (2003)
View Data	SEC1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..132]	PSI-BLAST	639.54902	Neuronal Sec1, NSec1
2	View Details	[133..264] [514..657]	PSI-BLAST	639.54902	Neuronal Sec1, NSec1
3	View Details	[265..384]	PSI-BLAST	639.54902	Neuronal Sec1, NSec1
4	View Details	[385..513]	PSI-BLAST	639.54902	Neuronal Sec1, NSec1
5	View Details	[658..724]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
SNARE binding	4.56428593085019	bayes_pls_golite062009
syntaxin binding	3.46044132736061	bayes_pls_golite062009
binding	2.7837022903231	bayes_pls_golite062009
protein binding	2.77285532000616	bayes_pls_golite062009
syntaxin-1 binding	0.269372794919901	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2