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Protein Overview: GIS1

General Information:
Name(s) found: GIS1 / YDR096W [SGD]
Description(s) found:
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  • gi|633630|emb|CAA87670.1| probable zinc finger protein [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6320301|ref|NP_010381.1| JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1; Gis1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51315832|sp|Q03833.1|GIS1_YEAST RecName: Full=Transcriptional activator/repressor GIS1 [NCBI NR]
  • pir||S51245 probable finger protein YDR096w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Transcriptional activator/repressor GIS1 OS=Saccharomyces cerevisiae GN=GIS1 PE=1 SV=1 [Swiss-Prot]
  • GIS1 DNA damage-responsive repressor of PHR1 [mips]
  • JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1 [SGD]
  • GIS1, Chr IV from 637132-639816 [yeast_orfs2]
  • Chr IV from 637132-639816 [yeastorf3.fasta]
  • >Q03833 (Q03833) Probable zinc finger protein [4932.FASTACCERV.txt]
  • GIS1 SGDID:S0002503, Chr IV from 637133-639817, Verified ORF [yeastflysequest.fasta]
  • GIS1 SGDID:S0002503, Chr IV from 637134-639818, Verified ORF [10112005cervSGD.fasta]
  • Transcriptional activator/repressor GIS1gi|6320301|ref|NP_010381.1| Gis1p [Saccharomyces cerevisiae]gi|633630|emb|CAA87670.1| probable zinc finger protein [Saccharomyces cerevisiae]gi|1078210|pir||S51245 probable finger protein YDR096w - yeast (Sacchar [nrdb_11152004_Chlamydomonas]
  • (Q03833) Transcriptional activator/repressor GIS1 [cerv4932.FASTAC]
  • GIS1 SGDID:S000002503, Chr IV from 637134-639818, Verified ORF, "Transcriptional factor, involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • GIS1 SGDID:S000002503, Chr IV from 637136-639820, Verified ORF, "Transcriptional factor, involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1" [yeast-contam.fasta]
  • GIS1 SGDID:S000002503, Chr IV from 637137-639821, Verified ORF, "JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • probable zinc finger protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Transcriptional activator/repressor GIS1 [nr-271106-contam.fasta]
  • Transcriptional factor, involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1; Gis1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Transcriptional activator/repressor GIS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GIS1 SGDID:S000002503, Chr IV from 637139-639823, Genome Release 64-1-1, Verified ORF, "JmjC domain-containing histone demethylase and transcription factor; involved in expression of genes during nutrient limitation; negatively regulates DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis; has a JmjC and a JmjN domain in the N-terminal region that interact, promoting Gis1p stability and proper transcriptional activity; contains transactivating domains TAD1 and TAD2 downstream of the Jmj domains and a C-terminal DNA binding domain" [yeast-030211-contam.fasta]
  • GIS1 SGDID:S000002503, Chr IV from 637139-639823, Genome Release 64-2-1, Verified ORF, "Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YDR096W SGDID:S000002503, Chr IV from 637139-639823, Genome Release 64-1-1, Verified ORF, "JmjC domain-containing histone demethylase and transcription factor; involved in expression of genes during nutrient limitation; negatively regulates DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis; has a JmjC and a JmjN domain in the N-terminal region that interact, promoting Gis1p stability and proper transcriptional activity; contains transactivating domains TAD1 and TAD2 downstream of the Jmj domains and a C-terminal DNA binding domain" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 894 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: phospholipid metabolic process [IMPLink to PubMed article]
    ascospore wall assembly [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIKPVEVID GVPVFKPSMM EFANFQYFID EITKFGIENG IVKVIPPKEW LELLEGSPPA  60
   61 ESLKTIQLDS PIQQQAKRWD KHENGVFSIE NEYDNKSYNL TQWKNLAESL DSRISQGDFN 120
  121 DKTLKENCRV DSQQDCYDLA QLQILESDFW KTIAFSKPFY AVDENSSIFP YDLTLWNLNN 180
  181 LPDSINSSNR RLLTGQSKCI FPWHLDEQNK CSINYLHFGA PKQWYSIPSA NTDQFLKILS 240
  241 KEPSSNKENC PAFIRHQNII TSPDFLRKNN IKFNRVVQFQ HEFIITFPYC MYSGFNYGYN 300
  301 FGESIEFILD QQAVVRKQPL KCGCGNKKEE RKSGPFSNLS YDSNESEQRG SITDNDNDLF 360
  361 QKVRSFDELL NHSSQELQNL EDNKNPLFSN INMNRPQSSS LRSTTPNGVN QFLNMNQTTI 420
  421 SRISSPLLSR MMDLSNIVEP TLDDPGSKFK RKVLTPQLPQ MNIPSNSSNF GTPSLTNTNS 480
  481 LLSNITATST NPSTTTNGSQ NHNNVNANGI NTSAAASINN NISSTNNSAN NSSSNNNVST 540
  541 VPSSMMHSST LNGTSGLGGD NDDNMLALSL ATLANSATAS PRLTLPPLSS PMNPNGHTSY 600
  601 NGNMMNNNSG NGSNGSNSYS NGVTTAAATT TSAPHNLSIV SPNPTYSPNP LSLYLTNSKN 660
  661 PLNSGLAPLS PSTSNIPFLK RNNVVTLNIS REASKSPISS FVNDYRSPLG VSNPLMYSST 720
  721 INDYSNGTGI RQNSNNINPL DAGPSFSPLH KKPKILNGND NSNLDSNNFD YSFTGNKQES 780
  781 NPSILNNNTN NNDNYRTSSM NNNGNNYQAH SSKFGENEVI MSDHGKIYIC RECNRQFSSG 840
  841 HHLTRHKKSV HSGEKPHSCP RCGKRFKRRD HVLQHLNKKI PCTQEMENTK LAES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SMC5 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GIS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] Pfam 28.508638 jmjN domain No confident structure predictions are available.
    2 View Details [80..136] deduced N/A No confident structure predictions are available.
    3 View Details [137..307] Pfam 50.327902 JmjC domain No confident structure predictions are available.
    4 View Details [308..395] MSA 19.514997 View MSA. No confident structure predictions are available.
    5 View Details [396..465] deduced N/A No confident structure predictions are available.
    6 View Details [466..615] PSI-BLAST 17.69897 Five-finger GLI1
    7 View Details [616..694] PSI-BLAST 89.24799 ZIF268
    8 View Details [695..775] MSA 13.281994 View MSA. No confident structure predictions are available.
    9 View Details [776..848] PSI-BLAST 2.69897 Tramtrack protein (two zinc-finger peptide)
    10 View Details [849..894] PSI-BLAST 78.30103 ADR1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  2.97176528779183 bayes_pls_golite062009
  • binding
    		•  2.95955830245165 bayes_pls_golite062009
  • DNA binding
    		•  2.78082210591574 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.53889200428466 bayes_pls_golite062009
  • chromatin binding
    		•  2.17816148863289 bayes_pls_golite062009
  • transcription factor activity
    		•  1.71320052881408 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.03479741823043 bayes_pls_golite062009
  • protein binding
    		•  1.02778071153188 bayes_pls_golite062009
  • transcription activator activity
    		•  0.90850120023053 bayes_pls_golite062009
  • histone binding
    		•  0.687710658383448 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.373557406294709 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.2354474590082 bayes_pls_golite062009
  • transcription factor binding
    		•  0.1746219785248 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle