Protein Overview: TPS2

General Information:
Name(s) found:	TPS2 / YDR074W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6320279\|ref\|NP_010359.1\| Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; Tps2p [Sacch [NCBI NR] pir\|\|S48761 trehalose-phosphatase (EC 3.1.3.12) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|577801\|emb\|CAA86796.1\| trehalose-phosphatase [Saccharomyces cerevisiae] [NCBI NR] gi\|1730010\|sp\|P31688.3\|TPS2_YEAST RecName: Full=Trehalose-phosphatase; AltName: Full=Trehalose-6-phosphate phosphatase; Short=TPP; AltName: Full=Trehalose synthase complex catalytic subunit TPS2 [NCBI NR] gi\|1431537\|emb\|CAA98893.1\| TPS2 [Saccharomyces cerevisiae] [NCBI NR] Trehalose-phosphatase OS=Saccharomyces cerevisiae GN=TPS2 PE=1 SV=3 [Swiss-Prot] TPS2 Alpha,alpha-trehalose-phosphate synthase, 102 KD subunit [mips] Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway [SGD] TPS2, Chr IV from 593887-596577 [yeast_orfs2] Chr IV from 593887-596577 [yeastorf3.fasta] (P31688) Trehalose-phosphatase (EC 3.1.3.12) (Trehalose 6-phosphate phosphatase) (TPP) [4932.FASTACCERV.txt] TPS2 SGDID:S0002481, Chr IV from 593888-596578, Verified ORF [yeastflysequest.fasta] TPS2 SGDID:S0002481, Chr IV from 593889-596579, Verified ORF [10112005cervSGD.fasta] Tps2p [Saccharomyces cerevisiae]gi\|1431537\|emb\|CAA98893.1\| TPS2 [Saccharomyces cerevisiae]gi\|577801\|emb\|CAA86796.1\| trehalose-phosphatase [Saccharomyces cerevisiae]gi\|630358\|pir\|\|S48761 trehalose-phosphatase (EC 3.1.3.12) - yeast (Saccharomyces cerevis [nrdb_11152004_Chlamydomonas] TPS2 SGDID:S000002481, Chr IV from 593889-596579, Verified ORF, "Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] TPS2 SGDID:S000002481, Chr IV from 593890-596580, Verified ORF, "Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed [yeast-contam.fasta] TPS2 SGDID:S000002481, Chr IV from 593891-596581, Verified ORF, "Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] trehalose-phosphatase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TPS2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Trehalose-phosphatase (Trehalose 6-phosphate phosphatase) (TPP) (Trehalose synthase complex catalytic subunit TPS2) [nr-271106-contam.fasta] Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; Tps2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TPS2 SGDID:S000002481, Chr IV from 593891-596581, Verified ORF, "Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway" [yeast-bovrabprots.fasta] TPS2 SGDID:S000002481, Chr IV from 593890-596580, Verified ORF, "Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway" [yeast-contam_custom.fasta] [chemostatdb.fasta] Trehalose-phosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPS2 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] TPS2 SGDID:S000002481, Chr IV from 593893-596583, Genome Release 64-1-1, Verified ORF, "Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway" [yeast-030211-contam.fasta] TPS2 SGDID:S000002481, Chr IV from 593893-596583, Genome Release 64-2-1, Verified ORF, "Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta] YDR074W SGDID:S000002481, Chr IV from 593893-596583, Genome Release 64-1-1, Verified ORF, "Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	896 amino acids
Gene Ontology:
Cellular Component:	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [IGI][IMP][IPI] mitochondrion [IDA ]
Biological Process:	trehalose biosynthetic process [IMP ] response to stress [IDA][IMP]
Molecular Function:	trehalose-phosphatase activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTTAQDNSP KKRQRIINCV TQLPYKIQLG ESNDDWKISA TTGNSALFSS LEYLQFDSTE  60
   61 YEQHVVGWTG EITRTERNLF TREAKEKPQD LDDDPLYLTK EQINGLTTTL QDHMKSDKEA 120
  121 KTDTTQTAPV TNNVHPVWLL RKNQSRWRNY AEKVIWPTFH YILNPSNEGE QEKNWWYDYV 180
  181 KFNEAYAQKI GEVYRKGDII WIHDYYLLLL PQLLRMKFND ESIIIGYFHH APWPSNEYFR 240
  241 CLPRRKQILD GLVGANRICF QNESFSRHFV SSCKRLLDAT AKKSKNSSNS DQYQVSVYGG 300
  301 DVLVDSLPIG VNTTQILKDA FTKDIDSKVL SIKQAYQNKK IIIGRDRLDS VRGVVQKLRA 360
  361 FETFLAMYPE WRDQVVLIQV SSPTANRNSP QTIRLEQQVN ELVNSINSEY GNLNFSPVQH 420
  421 YYMRIPKDVY LSLLRVADLC LITSVRDGMN TTALEYVTVK SHMSNFLCYG NPLILSEFSG 480
  481 SSNVLKDAIV VNPWDSVAVA KSINMALKLD KEEKSNLESK LWKEVPTIQD WTNKFLSSLK 540
  541 EQASSNDDME RKMTPALNRP VLLENYKQAK RRLFLFDYDG TLTPIVKDPA AAIPSARLYT 600
  601 ILQKLCADPH NQIWIISGRD QKFLNKWLGG KLPQLGLSAE HGCFMKDVSC QDWVNLTEKV 660
  661 DMSWQVRVNE VMEEFTTRTP GSFIERKKVA LTWHYRRTVP ELGEFHAKEL KEKLLSFTDD 720
  721 FDLEVMDGKA NIEVRPRFVN KGEIVKRLVW HQHGKPQDML KGISEKLPKD EMPDFVLCLG 780
  781 DDFTDEDMFR QLNTIETCWK EKYPDQKNQW GNYGFYPVTV GSASKKTVAK AHLTDPQQVL 840
  841 ETLGLLVGDV SLFQSAGTVD LDSRGHVKNS ESSLKSKLAS KAYVMKRSAS YTGAKV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		TPS1 TPS2 TPS3 TSL1
View Details	Krogan NJ, et al. (2006)		TPS1 TPS2 TPS3 TSL1
View Details	Gavin AC, et al. (2002)		CTR3 DAL3 GLN1 GTO3 IML1 MCM2 MKS1 REG1 TIF1, TIF2 TPS1 TPS2 TPS3 TSC10 TSL1 YIL177C
View Details	Ho Y, et al. (2002)		GND1 GPH1 HSP104 KGD1 NAN1 PFK1 SCS2 TPS2 UTP10 UTP9
View Details	Qiu et al. (2008)		TPS1 TPS2 TPS3 TSL1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	BOI1	Sample boi 1 with ha tag from october 2005	McCusker D, et al (2007)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#04 Alpha Factor Prep2	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	TPS2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..120]	deduced	N/A	No confident structure predictions are available.
2	View Details	[121..317] [524..545]	ORFEUS	13.39	UDP-N-acetylglucosamine 2-epimerase
3	View Details	[318..523]	ORFEUS	13.39	UDP-N-acetylglucosamine 2-epimerase
4	View Details	[546..896]	MSA	25.886997	View MSA. No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: TPS2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: