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Protein Overview: TPI1

General Information:
Name(s) found: TPI1 / YDR050C [SGD]
Description(s) found:
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  • gi|798902|emb|CAA89080.1| Tpi1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||ISBYT triose-phosphate isomerase (EC 5.3.1.1) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6320255|ref|NP_010335.1| Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; Tpi1 [NCBI NR]
  • gi|45269201|gb|AAS55980.1| YDR050C [Saccharomyces cerevisiae] [NCBI NR]
  • gi|136069|sp|P00942.2|TPIS_YEAST RecName: Full=Triosephosphate isomerase; Short=TIM; AltName: Full=Triose-phosphate isomerase [NCBI NR]
  • gi|1197083|gb|AAA88757.1| triose phosphate isomerase [Saccharomyces cerevisiae] [NCBI NR]
  • Triosephosphate isomerase OS=Saccharomyces cerevisiae GN=TPI1 PE=1 SV=2 [Swiss-Prot]
  • TPI1 Triose-phosphate isomerase [mips]
  • Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region [SGD]
  • TPI1, Chr IV from 555721-556467, reverse complement [yeast_orfs2]
  • Chr IV from 555721-556467, reverse complement [yeastorf3.fasta]
  • Chr IV from 556467-555721, reverse complement [yeastorf5.fasta]
  • TPI1 SGDID:S0002457, Chr IV from 556468-555722, reverse complement, Verified ORF [yeastflysequest.fasta]
  • TPI1 SGDID:S0002457, Chr IV from 556469-555723, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Tpi1p [Saccharomyces cerevisiae]gi|798902|emb|CAA89080.1| Tpi1p [Saccharomyces cerevisiae]gi|68428|pir||ISBYT triose-phosphate isomerase (EC 5.3.1.1) - yeast (Saccharomyces cerevisiae)gi|45269201|gb|AAS55980.1| YDR050C [Saccharomyces cerevisiae]gi|11 [nrdb_11152004_Chlamydomonas]
  • TPI1 SGDID:S000002457, Chr IV from 556469-555723, reverse complement, Verified ORF, "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1 [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • TPI1 SGDID:S000002457, Chr IV from 556470-555724, reverse complement, Verified ORF, "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1 [yeast-contam.fasta]
  • TPI1 SGDID:S000002457, Chr IV from 556471-555725, reverse complement, Verified ORF, "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1 [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • triose phosphate isomerase [nr-271106-contam.fasta]
  • Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; Tpi1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YDR050C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Triosephosphate isomerase (TIM) (Triose-phosphate isomerase) [nr-271106-contam.fasta]
  • Tpi1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • TPI1 SGDID:S000002457, Chr IV from 556471-555725, reverse complement, Verified ORF, "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region" [yeast-bovrabprots.fasta]
  • TPI1 SGDID:S000002457, Chr IV from 556470-555724, reverse complement, Verified ORF, "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Triosephosphate isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPI1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TPI1 SGDID:S000002457, Chr IV from 556472-555726, Genome Release 64-1-1, reverse complement, Verified ORF, "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region" [yeast-030211-contam.fasta]
  • TPI1 SGDID:S000002457, Chr IV from 556472-555726, Genome Release 64-2-1, reverse complement, Verified ORF, "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease" [20141208_orf_trans.fasta]
  • YDR050C SGDID:S000002457, Chr IV from 556472-555726, Genome Release 64-1-1, reverse complement, Verified ORF, "Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 248 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: glycolysis [IMPLink to PubMed article]
    Molecular Function: triose-phosphate isomerase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARTFFVGGN FKLNGSKQSI KEIVERLNTA SIPENVEVVI CPPATYLDYS VSLVKKPQVT  60
   61 VGAQNAYLKA SGAFTGENSV DQIKDVGAKW VILGHSERRS YFHEDDKFIA DKTKFALGQG 120
  121 VGVILCIGET LEEKKAGKTL DVVERQLNAV LEEVKDWTNV VVAYEPVWAI GTGLAATPED 180
  181 AQDIHASIRK FLASKLGDKA ASELRILYGG SANGSNAVTF KDKADVDGFL VGGASLKPEF 240
  241 VDIINSRN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADH1 FBA1 GPM1 HSC82 PDC1 TPI1
    View Details Gavin AC, et al. (2002) ADH1 ENO2 FAR11 FAR3 FBA1 GPM1 HFM1 HSC82 PDC1 ROM2 SNT2 SSE2 TPI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run DSN1 No Comments Hazbun TR, et al. (2003)
    View Run SDO1 No Comments Hazbun TR, et al. (2003)
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run DSN1 No Comments Hazbun TR, et al. (2003)
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TPI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..248] PSI-BLAST 1467.39794 Triosephosphate isomerase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • triose-phosphate isomerase activity
    		•  5.94525596131351 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  4.11751506069887 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting aldoses and ketoses
    		•  3.62219160185043 bayes_pls_golite062009
  • isomerase activity
    		•  2.06271139232842 bayes_pls_golite062009
  • binding
    		•  1.80264931081179 bayes_pls_golite062009
  • catalytic activity
    		•  1.7524198174984 bayes_pls_golite062009
  • protein binding
    		•  0.33788557654084 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle