Protein Overview: CDC13

General Information:
Name(s) found:	CDC13 / YDL220C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319981\|ref\|NP_010061.1\| Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; Cdc13p [Saccharomyces cerevisiae [NCBI NR] gi\|21903395\|sp\|P32797.2\|CDC13_YEAST RecName: Full=Cell division control protein 13 [NCBI NR] pir\|\|S27421 cell division control protein CDC13 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1431371\|emb\|CAA98800.1\| CDC13 [Saccharomyces cerevisiae] [NCBI NR] Cell division control protein 13 OS=Saccharomyces cerevisiae GN=CDC13 PE=1 SV=2 [Swiss-Prot] (P32797) Cell division control protein 13 [Swiss-Prot] CDC13 Cell division control protein [mips] Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping [SGD] CDC13, Chr IV from 62245-65019, reverse complement [yeast_orfs2] Chr IV from 62245-65019, reverse complement [yeastorf3.fasta] Chr IV from 65019-62245, reverse complement [yeastorf5.fasta] CDC13 SGDID:S0002379, Chr IV from 65019-62245, reverse complement, Verified ORF [yeastflysequest.fasta] Cdc13p [Saccharomyces cerevisiae]gi\|1431371\|emb\|CAA98800.1\| CDC13 [Saccharomyces cerevisiae]gi\|2144610\|pir\|\|S27421 cell division control protein CDC13 - yeast (Saccharomyces cerevisiae)gi\|21903395\|sp\|P32797\|CC13_YEAST Cell division control protein 13 [nrdb_11152004_Chlamydomonas] CDC13 SGDID:S000002379, Chr IV from 65019-62245, reverse complement, Verified ORF, "Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential functi [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Cell division control protein 13 [nr-271106-contam.fasta] CDC13 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; Cdc13p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CDC13 SGDID:S000002379, Chr IV from 65019-62245, reverse complement, Verified ORF, "Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Cell division control protein 13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC13 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CDC13 SGDID:S000002379, Chr IV from 65018-62244, Genome Release 64-1-1, reverse complement, Verified ORF, "Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping" [yeast-030211-contam.fasta] CDC13 SGDID:S000002379, Chr IV from 65018-62244, Genome Release 64-2-1, reverse complement, Verified ORF, "Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase, telomere end protection, conventional telomere replication; regulates telomere replication through recruitment of specific sub-complexes, essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle" [20141208_orf_trans.fasta] YDL220C SGDID:S000002379, Chr IV from 65018-62244, Genome Release 64-1-1, reverse complement, Verified ORF, "Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	924 amino acids
Gene Ontology:
Cellular Component:	nuclear telomere cap complex [IDA]
Biological Process:	telomere maintenance [IMP] telomere capping [TAS]
Molecular Function:	telomeric DNA binding [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTLEEPECP PHKNRIFVSS SKDFEGYPSK AIVPVQFVAL LTSIHLTETK CLLGFSNFER  60
   61 RGDQSQEDQY LIKLKFKDRG SERLARITIS LLCQYFDIEL PDLDSDSGAS PTVILRDIHL 120
  121 ERLCFSSCKA LYVSKHGNYT LFLEDIKPLD LVSVISTIST KSTNSSKHSS SELISECDLN 180
  181 NSLVDIFNNL IEMNRDEKNR FKFVKLIHYD IELKKFVQDQ QKVLSQKSKA AAINPFFVPN 240
  241 RLGIPYIESQ NEFNSQLMTL NVDEPTTDIS NMGEEMHDSA DPIEDSDSST TSSTGKYFSS 300
  301 KSYIQSQTPE RKTSVPNNWH DDDSGSKRKR KLSFHSPNAS SIRKAISYEQ LSLASVGSVE 360
  361 RLEGKIVGMN PPQFASINEF KYCTLKLYFT QLLPNVPDKV LVPGVNCIEI VIPTRERICE 420
  421 LFGVLNCQSD KISDILLLEK PDRISVEVER ILWDNDKTAS PGMAVWSLKN ISTDTQAQAQ 480
  481 VQVPAQSSAS IDPSRTRMSK MARKDPTIEF CQLGLDTFET KYITMFGMLV SCSFDKPAFI 540
  541 SFVFSDFTKN DIVQNYLYDR YLIDYENKLE LNEGFKAIMY KNQFETFDSK LRKIFNNGLR 600
  601 DLQNGRDENL SQYGIVCKMN IKVKMYNGKL NAIVRECEPV PHSQISSIAS PSQCEHLRLF 660
  661 YQRAFKRIGE SAISRYFEEY RRFFPIHRNG SHLAKLRFDE VKHEPKKSPT TPALAEHIPD 720
  721 LNADVSSFDV KFTDISSLLD SSARLPRPQQ THKSNTLYSC EGRIIAIEYH ASDLCFHITN 780
  781 ELPLLQTRGL APERVLQLHI ITSKNFAYFF NRSSAYLQRQ PLEEKYTQLA QFLGHSFKFN 840
  841 ITSSLTLFPD TTVALQIWCP IECTFRELQQ QLAHPKVAAA PDSGSLDCAI NATVNPLRLL 900
  901 AAQNGVTVKK EEDNDDDAGA VPTS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		BUD4 CDC13 CDC15 GIR2 PRS5 RBG2 YIL152W
View Details	Ho Y, et al. (2002)		ADH4 ASF1 BAT1 CDC13 CPR1 ECM10 EDE1 KAP95 PTC2 RAD53 SRP1 SWI4 TBF1 UTP22 YTA7
View Details	Qiu et al. (2008)		CDC13 RAP1 RIF1 RIF2 STN1 TBF1 TEN1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	PAN1	No Comments	Toshima J, et al (2006)
View Run	BOI1	Sample boi1 with gst from october 2005	McCusker D, et al (2007)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC13	STN1	2	Uetz P, et al. (2000)
View Screen	CDC13	SCS2	2	Unpublished Fields Lab Data
View Screen	CDC13	GIS3	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CDC13	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..490]	deduced	N/A	No confident structure predictions are available.
2	View Details	[491..641]	PSI-BLAST	1276.0	CDC13 ssDNA-binding domain
3	View Details	[642..744]	PSI-BLAST	1276.0	CDC13 ssDNA-binding domain
4	View Details	[745..924]	deduced	N/A	No confident structure predictions are available.
5	View Details	[706..924]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
telomerase inhibitor activity	8.08322438894165	bayes_pls_golite062009
single-stranded telomeric DNA binding	7.13197590913268	bayes_pls_golite062009
telomeric DNA binding	7.07761964836826	bayes_pls_golite062009
nucleic acid binding	3.99127970564994	bayes_pls_golite062009
DNA binding	3.53568546959418	bayes_pls_golite062009
structure-specific DNA binding	3.06066809614422	bayes_pls_golite062009
single-stranded DNA binding	3.0183551365402	bayes_pls_golite062009
DEAD/H-box RNA helicase binding	2.8741276864403	bayes_pls_golite062009
binding	2.83465364476231	bayes_pls_golite062009
structural constituent of ribosome	2.13063800565247	bayes_pls_golite062009
structural molecule activity	1.9177190829469	bayes_pls_golite062009
transcription regulator activity	1.84350127337404	bayes_pls_golite062009
DNA helicase activity	1.12203697857261	bayes_pls_golite062009
transcription factor activity	0.952569279670437	bayes_pls_golite062009
sequence-specific DNA binding	0.85691075793641	bayes_pls_golite062009
DNA-dependent ATPase activity	0.638831894247026	bayes_pls_golite062009
ribonuclease activity	0.62994126331969	bayes_pls_golite062009
nuclease activity	0.57381531077345	bayes_pls_golite062009
translation regulator activity	0.515576958825022	bayes_pls_golite062009
nucleotidyltransferase activity	0.491028860958185	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.468402630523277	bayes_pls_golite062009
exonuclease activity	0.28313884527829	bayes_pls_golite062009
translation initiation factor activity	0.2080607201312	bayes_pls_golite062009
protein binding	0.152645195799531	bayes_pls_golite062009
DNA-directed RNA polymerase activity	0.10868826895563	bayes_pls_golite062009
RNA polymerase activity	0.10868826895563	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.0179535526984695	bayes_pls_golite062009
helicase activity	0.0121541775159524	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2