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Protein Overview: CLH_YEAST

General Information:
Name(s) found: CLH_YEAST [Swiss-Prot]
Description(s) found:
  • Clathrin heavy chain OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CHC1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 1653 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLPIEFTE LVDLMSLGIS PQFLDFRSTT FESDHFVTVR ETKDGTNSVA IVDLAKGNEV  60
   61 TRKNMGGDSA IMHPSQMVIS VRANGTIVQI FNLETKSKLK SFTLDEPVIF WRWLSETTLG 120
  121 FVTARSILTS NVFDGNVNAK PQLLTLRHAN LNNTQIINFV ANKNLDWFAV VGILQENGRI 180
  181 AGRIQLFSKQ RNISQAIDGH VAIFTNILLE GNGSTPVQVF VTGNRNATTG AGELRIIEID 240
  241 HDASLPSQYQ KETTDIFFPP DATNDFPIAV QVSEKYGIIY LLTKYGFIHL YELETGTNLF 300
  301 VNRITAESVF TAAPYNHENG IACINKKGQV LAVEISTSQI VPYILNKLSN VALALIVATR 360
  361 GGLPGADDLF QKQFESLLLQ NDYQNAAKVA ASSTSLRNQN TINRLKNIQA PPGAISPILL 420
  421 YFSTLLDKGK LNKEETIELA RPVLQQDRKQ LFEKWLKEDK LECSEELGDI VKPFDTTLAL 480
  481 ACYLRAGAHA KVISCLAELQ QFEKIIPYCQ KVGYQPNFLV LISSLIRSSP DRASEFAVSL 540
  541 LQNPETASQI DIEKIADLFF SQNHIQQGTS LLLDALKGDT PDQGHLQTRV LEVNLLHAPQ 600
  601 VADAILGNNI FSHYDKPTIA SLSEKAGLYQ RALENYTDIK DIKRCVVHTN ALPIDWLVGY 660
  661 FGKLNVEQSL ACLKALMDNN IQANIQTVVQ VATKFSDLIG PSTLIKLFED YNATEGLYYY 720
  721 LASLVNLTED KDVVYKYIEA AAKMKQYREI ERIVKDNNVY DPERVKNFLK DANLEDQLPL 780
  781 VIVCDRFDFV HEMILYLYKS QNLKFIETYV QQVNPSKTAQ VVGALLDMDC DEAFIQSLLQ 840
  841 SVLGQVPINE LTTEVEKRNR LKILLPFLEQ SLSQGIQDQA VYNALAKIYI DSNNSPEKFL 900
  901 KENDQYDTLD VGHYCEKRDP YLAYIAYEKG QNDDDLIRIT NENSMYKYQA RYLLERSDLD 960
  961 LWNKVLNQEN IHRRQLIDSV ISVGIPELTD PEPVSLTVQA FMTNGLKLEL IELLEKIILE1020
 1021 PSPFNENVAL QGLLLLSAIK YEPTKVSSYI EKLDNYDADE IAPLCIEHDL KEEAFEIYDK1080
 1081 HEMYGKALKV LIEDIMSLDR AASYADKINT PELWSQIGTA QLDGLRIPDA IESYIKAEDP1140
 1141 SNYENVIDIA EQAGKYEELI PFLLMARKTL KEPKIDGALI LAYAELNKIH EIENLLAGSN1200
 1201 VANLDHVGDK LFENKEYKAA RLCYSAVSNY SKLASTLVYL GDYQAAVDTA RKASNIKVWK1260
 1261 LVNDACIEKK EFKLAQICGL NLIVHAEELD ELVERYESNG YFEELISLFE AGLGLERAHM1320
 1321 GMFTELAILY SKYEPDKTFE HLKLFWSRIN IPKVIRAVEQ AHLWSELVFL YAHYDEWDNA1380
 1381 ALTLIEKSTK DLDHAYFKEV VVKVSNLEIY YKAINFYVKF HPSLLVDLLT SLTPRLDIPR1440
 1441 TVKIFSKSDN LPLIKPFLIN VLPKNNSVVN QAYHDLMIEE EDYKALQDAV DSYDKFDQLG1500
 1501 LASRLESHKL IFFKKIGALL YRRNKKWAKS LSILKEEKLW KDAIETAAIS QDPKVVEALL1560
 1561 TYFVETGNRE GFVALLYAAY NLVRIEFVLE ISWMNSLEDY IKPFEISIKK EQNDSIKKIT1620
 1621 EELAKKSGSN EEHKDGQPLM LMNSAMNVQP TGF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..12]
    [199..362]    		 PSI-BLAST 2230.0 Clathrin heavy-chain linker domain; Clathrin heavy-chain terminal domain
    2 View Details [13..144]
    [363..430]    		 PSI-BLAST 2230.0 Clathrin heavy-chain linker domain; Clathrin heavy-chain terminal domain
    3 View Details [145..198]
    [431..498]    		 PSI-BLAST 2230.0 Clathrin heavy-chain linker domain; Clathrin heavy-chain terminal domain
    4 View Details [499..561] ORFEUS 12.01 Annexin VI
    5 View Details [562..806] ORFEUS 12.01 Annexin VI
    6 View Details [807..822]
    [894..1077]    		 ORFEUS 12.01 Annexin VI
    7 View Details [823..893] ORFEUS 12.01 Annexin VI
    8 View Details [1078..1550] PSI-BLAST 2330.0 Clathrin heavy chain proximal leg segment
    9 View Details [1551..1653] MSA 2.012966 View MSA. Confident ab initio structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle