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Protein Overview: VPS15

General Information:
Name(s) found: VPS15 / YBR097W [SGD]
Description(s) found:
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  • Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p [SGD]
  • [S288C.fasta]
  • Serine/threonine-protein kinase VPS15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS15 PE=1 SV=4 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • VPS15 SGDID:S000000301, Chr II from 436951-441315, Genome Release 64-1-1, Verified ORF, "Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p" [yeast-030211-contam.fasta]
  • VPS15 SGDID:S000000301, Chr II from 436951-441315, Genome Release 64-2-1, Verified ORF, "Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery" [20141208_orf_trans.fasta]
  • YBR097W SGDID:S000000301, Chr II from 436951-441315, Genome Release 64-1-1, Verified ORF, "Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1454 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Golgi membrane [TASLink to PubMed article]
    Biological Process: protein retention in Golgi apparatus [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    inositol lipid-mediated signaling [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAQLSLVVQ ASPSIAIFSY IDVLEEVHYV SQLNSSRFLK TCKALDPNGE IVIKVFIKPK  60
   61 DQYSLRPFLQ RIRAQSFKLG QLPHVLNYSK LIETNRAGYM IRQHLKNNLY DRLSLRPYLQ 120
  121 DIELKFIAFQ LLNALKDIHN LNIVHGDIKT ENILVTSWNW CILTDFAAFI KPVYLPEDNP 180
  181 GEFLFYFDTS KRRTCYLAPE RFNSKLYQDG KSNNGRLTKE MDIFSLGCVI AEIFAEGRPI 240
  241 FNLSQLFKYK SNSYDVNREF LMEEMNSTDL RNLVLDMIQL DPSKRLSCDE LLNKYRGIFF 300
  301 PDYFYTFIYD YFRNLVTMTT STPISDNTCT NSTLEDNVKL LDETTEKIYR DFSQICHCLD 360
  361 FPLIKDGGEI GSDPPILESY KIEIEISRFL NTNLYFPQNY HLVLQQFTKV SEKIKSVKEE 420
  421 CALLFISYLS HSIRSIVSTA TKLKNLELLA VFAQFVSDEN KIDRVVPYFV CCFEDSDQDV 480
  481 QALSLLTLIQ VLTSVRKLNQ LNENIFVDYL LPRLKRLLIS NRQNTNYLRI VFANCLSDLA 540
  541 IIINRFQEFT FAQHCNDNSM DNNTEIMESS TKYSAKLIQS VEDLTVSFLT DNDTYVKMAL 600
  601 LQNILPLCKF FGRERTNDII LSHLITYLND KDPALRVSLI QTISGISILL GTVTLEQYIL 660
  661 PLLIQTITDS EELVVISVLQ SLKSLFKTGL IRKKYYIDIS KTTSPLLLHP NNWIRQFTLM 720
  721 IIIEIINKLS KAEVYCILYP IIRPFFEFDV EFNFKSMISC CKQPVSRSVY NLLCSWSVRA 780
  781 SKSLFWKKII TNHVDSFGNN RIEFITKNYS SKNYGFNKRD TKSSSSLKGI KTSSTVYSHD 840
  841 NKEIPLTAED RNWIDKFHII GLTEKDIWKI VALRGYVIRT ARVMAANPDF PYNNSNYRPL 900
  901 VQNSPPNLNL TNIMPRNIFF DVEFAEESTS EGQDSNLENQ QIYKYDESEK DSNKLNINGS 960
  961 KQLSTVMDIN GSLIFKNKSI ATTTSNLKNV FVQLEPTSYH MHSPNHGLKD NANVKPERKV1020
 1021 VVSNSYEGDV ESIEKFLSTF KILPPLRDYK EFGPIQEIVR SPNMGNLRGK LIATLMENEP1080
 1081 NSITSSAVSP GETPYLITGS DQGVIKIWNL KEIIVGEVYS SSLTYDCSST VTQITMIPNF1140
 1141 DAFAVSSKDG QIIVLKVNHY QQESEVKFLN CECIRKINLK NFGKNEYAVR MRAFVNEEKS1200
 1201 LLVALTNLSR VIIFDIRTLE RLQIIENSPR HGAVSSICID EECCVLILGT TRGIIDIWDI1260
 1261 RFNVLIRSWS FGDHAPITHV EVCQFYGKNS VIVVGGSSKT FLTIWNFVKG HCQYAFINSD1320
 1321 EQPSMEHFLP IEKGLEELNF CGIRSLNALS TISVSNDKIL LTDEATSSIV MFSLNELSSS1380
 1381 KAVISPSRFS DVFIPTQVTA NLTMLLRKMK RTSTHSVDDS LYHHDIINSI STCEVDETPL1440
 1441 LVACDNSGLI GIFQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle