Protein Overview: EST2

General Information:
Name(s) found:	EST2 / YLR318W [SGD]
Description(s) found: SHOW ONLY BEST	Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia [SGD] [chemostatdb.fasta] Telomerase reverse transcriptase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EST2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] EST2 SGDID:S000004310, Chr XII from 766542-769196, Genome Release 64-1-1, Verified ORF, "Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia" [yeast-030211-contam.fasta] EST2 SGDID:S000004310, Chr XII from 766542-769196, Genome Release 64-2-1, Verified ORF, "Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia" [20141208_orf_trans.fasta] YLR318W SGDID:S000004310, Chr XII from 766542-769196, Genome Release 64-1-1, Verified ORF, "Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	884 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] telomerase holoenzyme complex [IDA][IPI] nucleolus [IDA] telomerase catalytic core complex [IDA][IPI][TAS]
Biological Process:	telomere maintenance [IMP] telomere maintenance via telomerase [IDA][IMP][TAS]
Molecular Function:	telomerase activity [IDA] telomeric template RNA reverse transcriptase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKILFEFIQD KLDIDLQTNS TYKENLKCGH FNGLDEILTT CFALPNSRKI ALPCLPGDLS  60
   61 HKAVIDHCII YLLTGELYNN VLTFGYKIAR NEDVNNSLFC HSANVNVTLL KGAAWKMFHS 120
  121 LVGTYAFVDL LINYTVIQFN GQFFTQIVGN RCNEPHLPPK WAQRSSSSSA TAAQIKQLTE 180
  181 PVTNKQFLHK LNINSSSFFP YSKILPSSSS IKKLTDLREA IFPTNLVKIP QRLKVRINLT 240
  241 LQKLLKRHKR LNYVSILNSI CPPLEGTVLD LSHLSRQSPK ERVLKFIIVI LQKLLPQEMF 300
  301 GSKKNKGKII KNLNLLLSLP LNGYLPFDSL LKKLRLKDFR WLFISDIWFT KHNFENLNQL 360
  361 AICFISWLFR QLIPKIIQTF FYCTEISSTV TIVYFRHDTW NKLITPFIVE YFKTYLVENN 420
  421 VCRNHNSYTL SNFNHSKMRI IPKKSNNEFR IIAIPCRGAD EEEFTIYKEN HKNAIQPTQK 480
  481 ILEYLRNKRP TSFTKIYSPT QIADRIKEFK QRLLKKFNNV LPELYFMKFD VKSCYDSIPR 540
  541 MECMRILKDA LKNENGFFVR SQYFFNTNTG VLKLFNVVNA SRVPKPYELY IDNVRTVHLS 600
  601 NQDVINVVEM EIFKTALWVE DKCYIREDGL FQGSSLSAPI VDLVYDDLLE FYSEFKASPS 660
  661 QDTLILKLAD DFLIISTDQQ QVINIKKLAM GGFQKYNAKA NRDKILAVSS QSDDDTVIQF 720
  721 CAMHIFVKEL EVWKHSSTMN NFHIRSKSSK GIFRSLIALF NTRISYKTID TNLNSTNTVL 780
  781 MQIDHVVKNI SECYKSAFKD LSINVTQNMQ FHSFLQRIIE MTVSGCPITK CDPLIEYEVR 840
  841 FTILNGFLES LSSNTSKFKD NIILLRKEIQ HLQAYIYIYI HIVN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.71

Protein Overview: EST2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: