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View Structure Prediction Details

Protein: CPOX
Organism: Homo sapiens
Length: 454 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPOX.

Description E-value Query
Range
Subject
Range
gi|23272125, gi|... - gi|62898694|dbj|BAD97201.1| coproporphyrinogen oxidase variant [Homo sapiens], gi|23272125|gb|AAH235...
0.0 [1..454] [1..454]
gi|114588132 - gi|114588132|ref|XP_516615.2| PREDICTED: coproporphyrinogen oxidase isoform 2 [Pan troglodytes]
0.0 [1..454] [1..454]
gi|109032659 - gi|109032659|ref|XP_001088605.1| PREDICTED: similar to coproporphyrinogen oxidase [Macaca mulatta]
0.0 [1..453] [1..452]
HEM6_MOUSE - Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Mus musculus GN=Cpox PE=1 SV=2
0.0 [1..453] [1..442]
HEM6_RAT - Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Rattus norvegicus GN=Cpox PE=1 SV=...
0.0 [1..453] [1..442]

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Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALQLGRLSS GPCWLVARGG CGGPRAWSQC GGGGLRAWSQ RSAAGRVCRP PGPAGTEQSR  60
   61 GLGHGSTSRG G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [72-454]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PWVGTGLAAA LAGLVGLATA AFGHVQRAEM LPKTSGTRAT SLGRPEEEED ELAHRCSSFM  60
   61 APPVTDLGEL RRRPGDMKTK MELLILETQA QVCQALAQVD GGANFSVDRW ERKEGGGGIS 120
  121 CVLQDGCVFE KAGVSISVVH GNLSEEAAKQ MRSRGKVLKT KDGKLPFCAM GVSSVIHPKN 180
  181 PHAPTIHFNY RYFEVEEADG NKQWWFGGGC DLTPTYLNQE DAVHFHRTLK EACDQHGPDL 240
  241 YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEVF RFVQSCARAV VPSYIPLVKK 300
  301 HCDDSFTPQE KLWQQLRRGR YVEFNLLYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH 360
  361 SPSENSKEAE ILEVLRHPRD WVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 172.0
Match: 2aexA
Description: The 1.58A Crystal Structure of Human Coproporphyrinogen Oxidase Reveals the Structural Basis of Hereditary Coproporphyria
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle