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View Structure Prediction Details

Protein: TAF1L
Organism: Homo sapiens
Length: 1826 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAF1L.

Description E-value Query
Range
Subject
Range
gi|111599525 - gi|111599525|gb|AAI16183.1| TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated f...
0.0 [1..1826] [1..1826]
TAF1_MOUSE - Transcription initiation factor TFIID subunit 1 OS=Mus musculus GN=Taf1 PE=1 SV=2
0.0 [1..1825] [1..1807]
gi|74007664 - gi|74007664|ref|XP_549070.2| PREDICTED: similar to TBP-associated factor 1 isoform 1 isoform 1 [Cani...
0.0 [1..1825] [1..1807]
gi|62667061, gi|... - gi|62667061|ref|XP_228551.3| PREDICTED: similar to TBP-associated factor 1 isoform 1 [Rattus norvegi...
0.0 [1..1825] [1..1807]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ LEGESVLDDE  60
   61 CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI RSTEDAVDYS DINEVAEDES 120
  121 QRHQQTMGSL QPLYHSDYDE DDYDADCEDI DCK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 1tbaA
Description: TAF(II)230 TBP-binding fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [154-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LMPPPPPPPG PMKKDKDQDA ITCVSESGED IILPSIIAPS FLASEKVDFS SYSDSESEMG  60
   61 P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [215-383]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEATQAESED GKLTLPLAGI MQHDATKLLP SVTELFPEFR PGKVLRFLHL FGPGKNVPSV  60
   61 WRSARRKRKK HRELIQEEQI QEVECSVESE VSQKSLWNYD YAPPPPPEQC LADDEITMMV 120
  121 PVESKFSQST GDVDKVTDTK PRVAEWRYGP ARLWYDMLGV SEDGSGFDY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [384-481]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFKLRKTQHE PVIKSRMMEE FRKLEESNGT DLLADENFLM VTQLHWEDSI IWDGEDIKHK  60
   61 GTKPQGASLA GWLPSIKTRN VMAYNVQQGF APTLDDDK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [482-583]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PWYSIFPIDN EDLVYGRWED NIIWDAQAMP RLLEPPVLAL DPNDENLILE IPDEKEEATS  60
   61 NSPSKESKKE SSLKKSRILL GKTGVIREEP QQNMSQPEVK DP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [584-644]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WNLSNDEYYF PKQQGLRGTF GGNIIQHSIP AMELWQPFFP THMGPIKIRQ FHRPPLKKYS  60
   61 F

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [645-887]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GALSQPGPHS VQPLLKHIKK KAKMREQERQ ASGGGELFFM RTPQDLTGKD GDLILAEYSE  60
   61 ENGPLMMQVG MATKIKNYYK RKPGKDPGAP DCKYGETVYC HTSPFLGSLH PGQLLQALEN 120
  121 NLFRAPVYLH KMPETDFLII RTRQGYYIRE LVDIFVVGQQ CPLFEVPGPN SRRANMHIRD 180
  181 FLQVFIYRLF WKSKDRPRRI RMEDIKKAFP SHSESSIRKR LKLCADFKRT GMDSNWWVLK 240
  241 SDF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [888-1269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLPTEEEIRA KVSPEQCCAY YSMIAAKQRL KDAGYGEKSF FAPEEENEED FQMKIDDEVH  60
   61 AAPWNTTRAF IAAMKGKCLL EVTGVADPTG CGEGFSYVKI PNKPTQQKDD KEPQAVKKTV 120
  121 TGTDADLRRL SLKNAKQLLR KFGVPEEEIK KLSRWEVIDV VRTMSTEQAH SGEGPMSKFA 180
  181 RGSRFSVAEH QERYKEECQR IFDLQNKVLS STEVLSTDTD SISAEDSDFE EMGKNIENML 240
  241 QNKKTSSQLS REWEEQERKE LRRMLLVAGS AASGNNHRDD VTASMTSLKS SATGHCLKIY 300
  301 RTFRDEEGKE YVRCETVRKP AVIDAYVRIR TTKDEKFIQK FALFDEKHRE EMRKERRRIQ 360
  361 EQLRRLKRNQ EKEKLKGPPE KK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.045757
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1270-1331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKKMKERPDL KLKCGACGAI GHMRTNKFCP LYYQTNVPPS KPVAMTEEQE EELEKTVIHN  60
   61 DN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1332-1713]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EELIKVEGTK IVFGKQLIEN VHEVRRKSLV LKFPKQQLPP KKKRRVGTTV HCDYLNIPHK  60
   61 SIHRRRTDPM VTLSSILESI INDMRDLPNT HPFHTPVNAK VVKDYYKIIT RPMDLQTLRE 120
  121 NVRKCLYPSR EEFREHLELI VKNSATYNGP KHSLTQISQS MLDLCDEKLK EKEDKLARLE 180
  181 KAINPLLDDD DQVAFSFILD NIVTQKMMAV PDSWPFHHPV NKKFVPDYYK MIVNPVDLET 240
  241 IRKNISKHKY QSRESFLDDV NLILANSVKY NGPESQYTKT AQEIVNICYQ TITEYDEHLT 300
  301 QLEKDICTAK EAALEEAELE SLDPMTPGPY TSQPPDMYDT NTSLSTSRDA SVFQDESNLS 360
  361 VLDISTATPE KQMCQGQGRL GE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.522879
Match: 1eqfA
Description: TAFII250 double bromodomain module
Matching Structure (courtesy of the PDB):

Predicted Domain #11
Region A:
Residues: [1714-1826]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDSDVDVEGY DDEEEDGKPK PPAPEGGDGD LADEEEGTVQ QPEASVLYED LLISEGEDDE  60
   61 EDAGSDEEGD NPFSAIQLSE SGSDSDVGYG GIRPKQPFML QHASGEHKDG HGK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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