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View Structure Prediction Details

Protein: CYFIP1
Organism: Homo sapiens
Length: 1253 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYFIP1.

Description E-value Query
Range
Subject
Range
gi|559703 - gi|559703|dbj|BAA07552.1| KIAA0068 [Homo sapiens]
2307.0 [0..1] [1253..19]
gi|60360032 - gi|60360032|dbj|BAD90235.1| mKIAA0068 protein [Mus musculus]
2304.0 [0..1] [1253..27]
gi|109079534 - gi|109079534|ref|XP_001105005.1| PREDICTED: similar to cytoplasmic FMR1 interacting protein 2 [Macac...
2287.0 [0..1] [1253..82]

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Predicted Domain #1
Region A:
Residues: [1-151]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAQVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSLLYQP NFNTNFEDRN AFVTGIARYI  60
   61 EQATVHSSMN EMLEEGQEYA VMLYTWRSCS RAIPQVKCNE QPNRVEIYEK TVEVLEPEVT 120
  121 KLMNFMYFQR NAIERFCGEV RRLCHAERRK D

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [152-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVSEAYLITL GKFINMFAVL DELKNMKCSV KNDHSAYKRA AQFLRKMADP QSIQESQNLS  60
   61 MFLANHNKIT QSLQQQLEVI SGYEELLADI VNLCVDYYEN RMYLTPSEKH MLLKVMGFGL 120
  121 YLMDGSVSNI YKLDAKKRIN LSKIDKYFKQ LQVVPLFGDM QIELARYIKT SAHYE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [327-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENKSRWTCTS SGSSPQYNIC EQMIQIREDH MRFISELARY SNSEVVTGSG RQEAQKTDAE  60
   61 YRKLFDLALQ GLQLLSQWSA HVMEVYSWKL VHPTDKYSNK DCPDSAEEYE RATRYNYTSE 120
  121 EKFALVEVIA MIKGLQVLMG RMESVFNHAI RHTVYAALQD FSQVTLREPL RQAIKKKKNV 180
  181 IQSVLQAIRK TVCDWETGHE PFNDPALRGE KDPKSGFDIK VP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [549-632]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRAVGPSSTQ LYMVRTMLES LIADKSGSKK TLRSSLEGPT ILDIEKFHRE SFFYTHLINF  60
   61 SETLQQCCDL SQLWFREFFL ELTM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.773 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.742 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.718 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.665 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.659 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.636 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.633 a.24.9 alpha-catenin/vinculin
View Download 0.620 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.584 a.59.1 PAH2 domain
View Download 0.540 a.60.1 SAM/Pointed domain
View Download 0.446 a.39.4 Hypothetical protein MTH865
View Download 0.354 a.4.1 Homeodomain-like
View Download 0.329 a.3.1 Cytochrome c
View Download 0.325 a.39.4 Hypothetical protein MTH865

Predicted Domain #5
Region A:
Residues: [633-877]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRRIQFPIEM SMPWILTDHI LETKEASMME YVLYSLDLYN DSAHYALTRF NKQFLYDEIE  60
   61 AEVNLCFDQF VYKLADQIFA YYKVMAGSLL LDKRLRSECK NQGATIHLPP SNRYETLLKQ 120
  121 RHVQLLGRSI DLNRLITQRV SAAMYKSLEL AIGRFESEDL TSIVELDGLL EINRMTHKLL 180
  181 SRYLTLDGFD AMFREANHNV SAPYGRITLH VFWELNYDFL PNYCYNGSTN RFVRTVLPFS 240
  241 QEFQR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [878-1114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKQPNAQPQY LHGSKALNLA YSSIYGSYRN FVGPPHFQVI CRLLGYQGIA VVMEELLKVV  60
   61 KSLLQGTILQ YVKTLMEVMP KICRLPRHEY GSPGILEFFH HQLKDIVEYA ELKTVCFQNL 120
  121 REVGNAILFC LLIEQSLSLE EVCDLLHAAP FQNILPRVHV KEGERLDAKM KRLESKYAPL 180
  181 HLVPLIERLG TPQQIAIARE GDLLTKERLC CGLSMFEVIL TRIRSFLDDP IWRGPLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1115-1191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNGVMHVDEC VEFHRLWSAM QFVYCIPVGT HEFTVEQCFG DGLHWAGCMI IVLLGQQRRF  60
   61 AVLDFCYHLL KVQKHDG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.751 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.707 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.682 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.651 a.8.11 Description not found.
View Download 0.646 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.615 d.6.1 Prion-like
View Download 0.588 a.8.11 Description not found.
View Download 0.547 a.64.1 Saposin
View Download 0.488 a.156.1 S13-like H2TH domain
View Download 0.399 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.389 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.388 a.159.4 Description not found.
View Download 0.371 d.50.1 dsRNA-binding domain-like

Predicted Domain #8
Region A:
Residues: [1192-1253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDEIIKNVPL KKMVERIRKF QILNDEIITI LDKYLKSGDG EGTPVEHVRC FQPPIHQSLA  60
   61 SS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.662 N/A N/A a.7.17 Description not found.
View Download 0.563 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.535 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.489 N/A N/A a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.478 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.470 N/A N/A a.23.7 Description not found.
View Download 0.420 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.403 N/A N/A a.4.1 Homeodomain-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle