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View Structure Prediction Details

Protein: PRPH
Organism: Homo sapiens
Length: 470 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRPH.

Description E-value Query
Range
Subject
Range
gi|109481333 - gi|109481333|ref|XP_001064779.1| PREDICTED: similar to keratin Kb40 [Rattus norvegicus]
9.0E-71 [1..410] [149..569]
gi|109096771 - gi|109096771|ref|XP_001093676.1| PREDICTED: keratin, hair, basic, 4 [Macaca mulatta]
2.0E-66 [3..409] [49..478]
gi|73996557 - gi|73996557|ref|XP_850166.1| PREDICTED: similar to keratin, hair, basic, 3 [Canis familiaris]
1.0E-65 [5..409] [109..515]
gi|46485130, gi|... - gi|47086911|ref|NP_997652.2| keratin Kb40 [Mus musculus], gi|46485130|tpg|DAA04930.1| TPA: TPA_exp: ...
5.0E-65 [1..410] [1..421]
gi|42760016 - gi|42760016|emb|CAF31524.1| type II hair keratin 4 [Homo sapiens]
1.0E-63 [3..409] [47..476]

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Predicted Domain #1
Region A:
Residues: [1-68]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHHPSGLRA GFSSTSYRRT FGPPPSLSPG AFSYSSSSRF SSSRLLGSAS PSSSVRLGSF  60
   61 RSPRAGAG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 4.958607
Match: PF04732.5
Description: No description for PF04732.5 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [69-334]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALLRLPSERL DFSMAEALNQ EFLATRSNEK QELQELNDRF ANFIEKVRFL EQQNAALRGE  60
   61 LSQARGQEPA RADQLCQQEL RELRRELELL GRERDRVQVE RDGLAEDLAA LKQRLEEETR 120
  121 KREDAEHNLV LFRKDVDDAT LSRLELERKI ESLMDEIEFL KKLHEEELRD LQVSVESQQV 180
  181 QQVEVEATVK PELTAALRDI RAQYESIAAK NLQEAEEWYK SKYADLSDAA NRNHEALRQA 240
  241 KQEMNESRRQ IQSLTCEVDG LRGTNE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.01
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #3
Region A:
Residues: [335-470]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALLRQLRELE EQFALEAGGY QAGAARLEEE LRQLKEEMAR HLREYQELLN VKMALDIEIA  60
   61 TYRKLLEGEE SRISVPVHSF ASLNIKTTVP EVEPPQDSHS RKTVLIKTIE TRNGEVVTES 120
  121 QKEQRSELDK SSAHSY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.30103
Match: 1gk4A
Description: Vimentin coil
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle