YRC Public Data Repository - Protein Structure Prediction

Protein:	YHHF_ECOLI
Organism:	Escherichia coli
Length:	198 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YHHF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|157162942, gi... - gi\|75197391\|ref\|ZP_00707461.1\| COG0742: N6-adenine-specific methylase [Escherichia coli HS], gi\|1571...	197.0	[0..1]	[198..1]
gi\|194425231, gi... - gi\|83588673\|ref\|ZP_00927297.1\| COG0742: N6-adenine-specific methylase [Escherichia coli 101-1], gi\|1... gi\|254163389, gi... - gi\|254163389\|ref\|YP_003046497.1\| predicted methyltransferase [Escherichia coli B str. REL606], gi\|25... gi\|251786713, gi... - gi\|251786713\|ref\|YP_003001017.1\| hypothetical protein B21_03267 [Escherichia coli BL21], gi\|24237898... gi\|254290139, gi... - gi\|254290139\|ref\|YP_003055887.1\| predicted methyltransferase [Escherichia coli BL21(DE3)], gi\|253979...	193.0	[0..1]	[198..1]
gi\|208735414, gi... - gi\|208814137\|ref\|ZP_03255466.1\| putative methyltransferase [Escherichia coli O157:H7 str. EC4045], g... gi\|208738975, gi... - gi\|208818852\|ref\|ZP_03259172.1\| putative methyltransferase [Escherichia coli O157:H7 str. EC4042], g... gi\|254795385, gi... - gi\|254795385\|ref\|YP_003080222.1\| hypothetical protein ECSP_4421 [Escherichia coli O157:H7 str. TW143... gi\|209159500, gi... - gi\|209398100\|ref\|YP_002272909.1\| putative methyltransferase [Escherichia coli O157:H7 str. EC4115], ... gi\|217325449, gi... - gi\|217325449\|ref\|ZP_03441533.1\| putative methyltransferase [Escherichia coli O157:H7 str. TW14588], ... gi\|189374523, gi... - gi\|189374523\|gb\|EDU92939.1\| 16S rRNA methyltransferase RsmD [Escherichia coli O157:H7 str. EC869], g... gi\|168797251, gi... - gi\|189380114\|gb\|EDU98530.1\| 16S rRNA methyltransferase RsmD [Escherichia coli O157:H7 str. EC508], g... gi\|195934959 - gi\|195934959\|ref\|ZP_03080341.1\| 16S rRNA m(2)G966-methyltransferase [Escherichia coli O157:H7 str. E... gi\|208727660, gi... - gi\|208807859\|ref\|ZP_03250196.1\| putative methyltransferase [Escherichia coli O157:H7 str. EC4206], g... gi\|189369895, gi... - gi\|189369895\|gb\|EDU88311.1\| 16S rRNA methyltransferase RsmD [Escherichia coli O157:H7 str. EC4501], ... gi\|168765828, gi... - gi\|189364612\|gb\|EDU83031.1\| 16S rRNA methyltransferase RsmD [Escherichia coli O157:H7 str. EC4486], ... gi\|168772626, gi... - gi\|187771400\|gb\|EDU35244.1\| 16S rRNA methyltransferase RsmD [Escherichia coli O157:H7 str. EC4196], ... gi\|168779564, gi... - gi\|189002360\|gb\|EDU71346.1\| 16S rRNA methyltransferase RsmD [Escherichia coli O157:H7 str. EC4076], ... gi\|25302516, gi\|... - pir\|\|B86014 hypothetical protein yhhF [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|13363788, gi\|... - gi\|15833568\|ref\|NP_312341.1\| 16S rRNA m(2)G966-methyltransferase [Escherichia coli O157:H7 str. Saka... gi\|15803977, gi\|... - gi\|15803977\|ref\|NP_290013.1\| 16S rRNA m(2)G966-methyltransferase [Escherichia coli O157:H7 EDL933], ... gi\|188018386, gi... - gi\|188018386\|gb\|EDU56508.1\| 16S rRNA methyltransferase RsmD [Escherichia coli O157:H7 str. EC4113], ... gi\|13363788, gi\|... - gi\|15833568\|ref\|NP_312341.1\| hypothetical protein ECs4314 [Escherichia coli O157:H7], gi\|13363788\|db... gi\|189359340, gi... - gi\|189359340\|gb\|EDU77759.1\| 16S rRNA methyltransferase RsmD [Escherichia coli O157:H7 str. EC4401], ...	192.0	[0..1]	[198..1]
gi\|82778729, gi\|... - gi\|82778729\|ref\|YP_405078.1\| 16S rRNA m(2)G966-methyltransferase [Shigella dysenteriae Sd197], gi\|81...	192.0	[0..1]	[198..1]
gi\|191170380, gi... - gi\|75242738\|ref\|ZP_00726482.1\| COG0742: N6-adenine-specific methylase [Escherichia coli F11], gi\|191... gi\|110345297, gi... - gi\|110643705\|ref\|YP_671435.1\| 16S rRNA m(2)G966-methyltransferase [Escherichia coli 536], gi\|1103452...	191.0	[0..1]	[198..1]
gi\|110616840, gi... - gi\|110807292\|ref\|YP_690812.1\| 16S rRNA m(2)G966-methyltransferase [Shigella flexneri 5 str. 8401], g...	191.0	[0..1]	[198..1]
gi\|187431180, gi... - gi\|75179910\|ref\|ZP_00699897.1\| COG0742: N6-adenine-specific methylase [Shigella boydii BS512], gi\|18...	191.0	[0..1]	[198..1]
gi\|116188001, gi... - gi\|75829569\|ref\|ZP_00758867.1\| COG0742: N6-adenine-specific methylase [Vibrio cholerae MO10], gi\|254... gi\|75828021, gi\|... - gi\|75828021\|ref\|ZP_00757456.1\| COG0742: N6-adenine-specific methylase [Vibrio cholerae O395], gi\|227... gi\|75823051, gi\|... - gi\|75823051\|ref\|ZP_00752586.1\| COG0742: N6-adenine-specific methylase [Vibrio cholerae RC385], gi\|11... gi\|116220327, gi... - gi\|75819441\|ref\|ZP_00749521.1\| COG0742: N6-adenine-specific methylase [Vibrio cholerae V51], gi\|1162... gi\|75815361, gi\|... - gi\|75815361\|ref\|ZP_00745875.1\| COG0742: N6-adenine-specific methylase [Vibrio cholerae V52], gi\|1217... gi\|11278454 - pir\|\|A82360 conserved hypothetical protein VC0146 [imported] - Vibrio cholerae (strain N16961 serogr... gi\|121587728, gi... - gi\|121587728\|ref\|ZP_01677489.1\| conserved hypothetical protein [Vibrio cholerae 2740-80], gi\|1215480... gi\|153214835, gi... - gi\|153214835\|ref\|ZP_01949643.1\| conserved hypothetical protein [Vibrio cholerae 1587], gi\|124115078\|... gi\|254291952, gi... - gi\|254291952\|ref\|ZP_04962733.1\| conserved hypothetical protein [Vibrio cholerae AM-19226], gi\|197750... gi\|153818951, gi... - gi\|153818951\|ref\|ZP_01971618.1\| conserved hypothetical protein [Vibrio cholerae NCTC 8457], gi\|12651... gi\|153822321, gi... - gi\|229508898\|ref\|ZP_04398388.1\| ribosomal RNA small subunit methyltransferase D [Vibrio cholerae B33... gi\|227008269, gi... - gi\|227080381\|ref\|YP_002808932.1\| Putative methylase [Vibrio cholerae M66-2], gi\|227008269\|gb\|ACP0448... gi\|229508421, gi... - gi\|229508421\|ref\|ZP_04397925.1\| ribosomal RNA small subunit methyltransferase D [Vibrio cholerae BX ... gi\|15640177, gi\|... - gi\|9654547\|gb\|AAF93323.1\| conserved hypothetical protein [Vibrio cholerae O1 biovar El Tor str. N169... gi\|229517012, gi... - gi\|229517012\|ref\|ZP_04406458.1\| ribosomal RNA small subunit methyltransferase D [Vibrio cholerae RC9... gi\|229342853, gi... - gi\|229520065\|ref\|ZP_04409493.1\| ribosomal RNA small subunit methyltransferase D [Vibrio cholerae TM ... gi\|229525039, gi... - gi\|229525039\|ref\|ZP_04414444.1\| ribosomal RNA small subunit methyltransferase D [Vibrio cholerae bv.... gi\|229369349, gi... - gi\|229606694\|ref\|YP_002877342.1\| ribosomal RNA small subunit methyltransferase D [Vibrio cholerae MJ...	190.0	[0..5]	[192..12]
gi\|24114725, gi\|... - gi\|24114725\|ref\|NP_709235.1\| 16S rRNA m(2)G966-methyltransferase [Shigella flexneri 2a str. 301], gi... gi\|30043520, gi\|... - gi\|30065258\|ref\|NP_839429.1\| 16S rRNA m(2)G966-methyltransferase [Shigella flexneri 2a str. 2457T], ...	190.0	[0..1]	[198..1]
gi\|238789410, gi... - gi\|77973659\|ref\|ZP_00829205.1\| COG0742: N6-adenine-specific methylase [Yersinia frederiksenii ATCC 3...	189.0	[0..2]	[198..10]

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Predicted Domain #1

Region A:
Residues: [1-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKPNHSGSG QIRIIGGQWR GRKLPVPDSP GLRPTTDRVR ETLFNWLAPV IVDAQCLDCF  60
   61 AGSGALGLEA LSRYAAGATL IEMDRAVSQQ LIKNLATLKA GNARVVNSNA MSFLAQKGTP 120
  121 HNIVFVDPPF RRGLLEETIN LLEDNGWLAD EALIYVESEV ENGLPTVPAN WSLHREKVAG 180
  181 QVAYRLYQRE AQGESDAD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	49.39794
Match:	2fpoA
Description:	Putative methyltransferase yhhF from Escherichia coli.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
rRNA methyltransferase activity	4.09362182773099	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
N-methyltransferase activity	3.0539218951403	bayes_pls_golite062009
protein methyltransferase activity	3.01384869242051	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
histone methyltransferase activity	1.90505369820945	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	1.83964463328968	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	1.75675289134467	bayes_pls_golite062009
DNA-methyltransferase activity	1.63765148226572	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
tRNA methyltransferase activity	1.12859857407629	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	1.10713374933008	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	1.05897361334523	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	0.639377525568296	bayes_pls_golite062009
rRNA (guanine-N2-)-methyltransferase activity	0.427131446117391	bayes_pls_golite062009
rRNA (cytosine) methyltransferase activity	0.346042596102079	bayes_pls_golite062009
O-methyltransferase activity	0.250946859465502	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.130104080746388	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.130042730841119	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: