YRC Public Data Repository - Protein Structure Prediction

Protein:	YFFH_ECOLI
Organism:	Escherichia coli
Length:	191 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFFH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|238799355, gi... - gi\|77960884\|ref\|ZP_00824738.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ...	187.0	[0..1]	[191..1]
gi\|238783884, gi... - gi\|77959004\|ref\|ZP_00823029.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ...	187.0	[0..1]	[191..1]
gi\|238728697, gi... - gi\|77977001\|ref\|ZP_00832463.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ...	180.0	[0..1]	[190..11]
gi\|88709484, gi\|... - gi\|88712078\|ref\|ZP_01106165.1\| hypothetical protein FB2170_14353 [Flavobacteriales bacterium HTCC217...	170.0	[0..5]	[191..19]
NUDK_ERWCT - GDP-mannose pyrophosphatase nudK OS=Erwinia carotovora subsp. atroseptica GN=nudK PE=3 SV=1 NUDK_PECAS - GDP-mannose pyrophosphatase NudK OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN...	170.0	[0..1]	[190..1]
gi\|26109242, gi\|... - gi\|26248836\|ref\|NP_754876.1\| hypothetical protein c2994 [Escherichia coli CFT073], gi\|26109242\|gb\|AA... gi\|237704981, gi... - gi\|237704981\|ref\|ZP_04535462.1\| GDP-mannose pyrophosphatase nudK [Escherichia sp. 3_2_53FAA], gi\|226... gi\|91073372, gi\|... - gi\|91211798\|ref\|YP_541784.1\| hypothetical protein UTI89_C2793 [Escherichia coli UTI89], gi\|91073372\|...	169.0	[0..1]	[191..10]
gi\|254593811, gi... - gi\|254794411\|ref\|YP_003079248.1\| GDP-mannose pyrophosphatase [Escherichia coli O157:H7 str. TW14359]... NUDK_ECO57 - GDP-mannose pyrophosphatase NudK OS=Escherichia coli O157:H7 GN=nudK PE=3 SV=1 gi\|217327582, gi... - gi\|217327582\|ref\|ZP_03443665.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. TW14588], gi\|... gi\|209763816, gi... - pir\|\|D85889 hypothetical protein yffH [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|15802989, gi\|... - gi\|15802989\|ref\|NP_289019.1\| hypothetical protein Z3723 [Escherichia coli O157:H7 EDL933], gi\|125168... gi\|208726784, gi... - gi\|208806983\|ref\|ZP_03249320.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4206], gi\|2... NUDK_SHIDS - GDP-mannose pyrophosphatase NudK OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=nudK PE=3 SV=1 gi\|208812164, gi... - gi\|208812164\|ref\|ZP_03253493.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4045], gi\|2... gi\|208739916, gi... - gi\|208819793\|ref\|ZP_03260113.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4042], gi\|2... gi\|209161144, gi... - gi\|209399744\|ref\|YP_002271935.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4115], gi\|... gi\|189003249, gi... - gi\|189003249\|gb\|EDU72235.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4076], gi\|16877... gi\|168787805, gi... - gi\|189372369\|gb\|EDU90785.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC869], gi\|168787... gi\|189378674, gi... - gi\|189378674\|gb\|EDU97090.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC508], gi\|168798... gi\|195936608 - gi\|195936608\|ref\|ZP_03081990.1\| hypothetical protein EscherichcoliO157_09130 [Escherichia coli O157:... gi\|189356578, gi... - gi\|189356578\|gb\|EDU74997.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4401], gi\|16875... gi\|168761068, gi... - gi\|189368367\|gb\|EDU86783.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4501], gi\|16876... gi\|168768551, gi... - gi\|189362205\|gb\|EDU80624.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4486], gi\|16876... gi\|187770616, gi... - gi\|187770616\|gb\|EDU34460.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4196], gi\|16877... gi\|15832583, gi\|... - gi\|15832583\|ref\|NP_311356.1\| hypothetical protein ECs3329 [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|188017097, gi... - gi\|188017097\|gb\|EDU55219.1\| hydrolase, NUDIX family [Escherichia coli O157:H7 str. EC4113], gi\|16874...	169.0	[0..1]	[191..1]
gi\|24113796, gi\|... - gi\|24113796\|ref\|NP_708306.1\| hypothetical protein SF2509 [Shigella flexneri 2a str. 301], gi\|2405288... gi\|30042102, gi\|... - gi\|30063847\|ref\|NP_838018.1\| hypothetical protein S2660 [Shigella flexneri 2a str. 2457T], gi\|300421... NUDK_SHIF8 - GDP-mannose pyrophosphatase NudK OS=Shigella flexneri serotype 5b (strain 8401) GN=nudK PE=3 SV=1 NUDK_SHIFL - GDP-mannose pyrophosphatase NudK OS=Shigella flexneri GN=nudK PE=3 SV=1	168.0	[0..1]	[191..1]
gi\|194437586, gi... - gi\|83586885\|ref\|ZP_00925516.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ...	168.0	[0..1]	[191..1]
NUDK_ECOL5 - GDP-mannose pyrophosphatase NudK OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=nudK PE=3 SV=... gi\|218690593, gi... - gi\|218690593\|ref\|YP_002398805.1\| putative NUDIX hydrolase [Escherichia coli ED1a], gi\|218428157\|emb\|... gi\|227835853, gi... - gi\|227887503\|ref\|ZP_04005308.1\| possible ADP-ribose diphosphatase [Escherichia coli 83972], gi\|22783... NUDK_ECOK1 - GDP-mannose pyrophosphatase NudK OS=Escherichia coli O1:K1 / APEC GN=nudK PE=3 SV=1 NUDK_ECOUT - GDP-mannose pyrophosphatase NudK OS=Escherichia coli (strain UTI89 / UPEC) GN=nudK PE=3 SV=2 NUDK_ECOL6 - GDP-mannose pyrophosphatase NudK OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=n... NUDK_ECOL6 - GDP-mannose pyrophosphatase nudK OS=Escherichia coli O6 GN=nudK PE=3 SV=2 gi\|215265840, gi... - gi\|215487768\|ref\|YP_002330199.1\| predicted NUDIX hydrolase [Escherichia coli O127:H6 str. E2348/69],... gi\|191172915, gi... - gi\|75240116\|ref\|ZP_00724075.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... gi\|218366171, gi... - gi\|218559402\|ref\|YP_002392315.1\| putative NUDIX hydrolase [Escherichia coli S88], gi\|218366171\|emb\|C...	168.0	[0..1]	[191..1]

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Predicted Domain #1

Region A:
Residues: [1-191]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQQITLIKD KILSDNYFTL HNITYDLTRK DGEVIRHKRE VYDRGNGATI LLYNTKKKTV  60
   61 VLIRQFRVAT WVNGNESGQL IESCAGLLDN DEPEVCIRKE AIEETGYEVG EVRKLFELYM 120
  121 SPGGVTELIH FFIAEYSDNQ RANAGGGVED EDIEVLELPF SQALEMIKTG EIRDGKTVLL 180
  181 LNYLQTSHLM D

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.221849
Match:	1viuA
Description:	Crystal structure of putative ADP ribose pyrophosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.49075808737475	bayes_pls_golite062009
hydrolase activity	0.914814648797509	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.60834739024706	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.608343780811364	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: