YRC Public Data Repository - Protein Structure Prediction

Protein:	YEGE_ECOLI
Organism:	Escherichia coli
Length:	1105 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YEGE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|194436365, gi... - gi\|83588060\|ref\|ZP_00926685.1\| COG2202: FOG: PAS/PAC domain [Escherichia coli 101-1], gi\|194436365\|r...	549.0	[0..1]	[1105..1]
gi\|73856069, gi\|... - gi\|74312592\|ref\|YP_311011.1\| putative sensor protein [Shigella sonnei Ss046], gi\|73856069\|gb\|AAZ8877...	548.0	[0..1]	[1105..1]
gi\|187730854, gi... - gi\|75177187\|ref\|ZP_00697285.1\| COG2202: FOG: PAS/PAC domain [Shigella boydii BS512], gi\|187730854\|re...	547.0	[0..1]	[1105..1]
gi\|193069275, gi... - gi\|75236263\|ref\|ZP_00720372.1\| COG2202: FOG: PAS/PAC domain [Escherichia coli E110019], gi\|193069275...	547.0	[0..1]	[1105..1]
gi\|75259205, gi\|... - gi\|75259205\|ref\|ZP_00730553.1\| COG2202: FOG: PAS/PAC domain [Escherichia coli E22], gi\|193062885\|ref... gi\|209919532, gi... - gi\|209919532\|ref\|YP_002293616.1\| putative sensor protein [Escherichia coli SE11], gi\|209912791\|dbj\|B...	547.0	[0..1]	[1105..1]
gi\|226900890, gi... - gi\|237704524\|ref\|ZP_04535005.1\| conserved hypothetical protein [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|218558948, gi... - gi\|218558948\|ref\|YP_002391861.1\| putative sensor protein [Escherichia coli S88], gi\|218365717\|emb\|CA... gi\|91072930, gi\|... - gi\|91211356\|ref\|YP_541342.1\| putative sensor protein [Escherichia coli UTI89], gi\|91072930\|gb\|ABE078... gi\|117624264, gi... - gi\|117624264\|ref\|YP_853177.1\| putative sensor protein [Escherichia coli APEC O1], gi\|115513388\|gb\|AB...	546.0	[0..1]	[1105..1]
gi\|15804978 - gi\|15804978\|ref\|NP_288575.1\| putative sensor protein [Escherichia coli O157:H7 EDL933]	546.0	[0..1]	[1105..1]
gi\|26108847, gi\|... - gi\|26248442\|ref\|NP_754482.1\| putative sensor protein [Escherichia coli CFT073], gi\|26108847\|gb\|AAN81...	545.0	[0..1]	[1105..1]
gi\|157077998, gi... - gi\|75186865\|ref\|ZP_00700132.1\| COG2202: FOG: PAS/PAC domain [Escherichia coli E24377A], gi\|157155968...	545.0	[0..1]	[1105..1]
gi\|110642277, gi... - gi\|110642277\|ref\|YP_670007.1\| putative sensor protein [Escherichia coli 536], gi\|110343869\|gb\|ABG701... gi\|191170041, gi... - gi\|75242889\|ref\|ZP_00726595.1\| COG2202: FOG: PAS/PAC domain [Escherichia coli F11], gi\|191170041\|ref...	544.0	[0..1]	[1105..1]

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Predicted Domain #1

Region A:
Residues: [1-183]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKQSQHVLI ALPHPLLHLV SLGLVSFIFT LFSLELSQFG TQLAPLWFPT SIMMVAFYRH  60
   61 AGRMWPGIAL SCSLGNIAAS ILLFSTSSLN MTWTTINIVE AVVGAVLLRK LLPWYNPLQN 120
  121 LADWLRLALG SAIVPPLLGG VLVVLLTPGD DPLRAFLIWV LSESIGALAL VPLGLLFKPH 180
  181 YLL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [184-310]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RHRNPRLLFE SLLTLAITLT LSWLSMLYLP WPFTFIIVLL MWSAVRLPRM EAFLIFLTTV  60
   61 MMVSLMMAAD PSLLATPRTY LMSHMPWLPF LLILLPANIM TMVMYAFRAE RKHISESETH 120
  121 FRNAMEY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [311-424]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAIGMALVGT EGQWLQTNKA LCQFLGYSQE ELRGLTFQQL TWPEDLNKDL QQVEKLISGE  60
   61 INTYSMEKRY YNRNGDVVWA LLAVSLVRHT DGTPLYFIAQ IEDINELKRT EQVN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.39794
Match:	2gj3A
Description:	No description for 2gj3A was found.

Predicted Domain #4

Region A:
Residues: [425-661]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQLMERITLA NEAGGIGIWE WELKPNIFSW DKRMFELYEI PPHIKPNWQV WYECVLPEDR  60
   61 QHAEKVIRDS LQSRSPFKLE FRITVKDGIR HIRALANRVL NKEGEVERLL GINMDMTEVK 120
  121 QLNEALFQEK ERLHITLDSI GEAVVCIDMA MKITFMNPVA EKMSGWTQEE ALGVPLLTVL 180
  181 HITFGDNGPL MENIYSADTS RSAIEQDVVL HCRSGGSYDV HYSITPLSTL DGSNIGS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.7
Match:	1wa9A
Description:	Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [662-845]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLVIQDVTES RKMLRQLSYS ASHDALTHLA NRASFEKQLR ILLQTVNSTH QRHALVFIDL  60
   61 DRFKAVNDSA GHAAGDALLR ELASLMLSML RSSDVLARLG GDEFGLLLPD CNVESARFIA 120
  121 TRIISAVNDY HFIWEGRVHR VGASAGITLI DDNNHQAAEV MSQADIACYA SKNGGRGRVT 180
  181 VYEP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.522879
Match:	1w25A
Description:	Response regulator PleD in complex with c-diGMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component response regulator activity	2.50016974643612	bayes_pls_golite062009
signal transducer activity	1.69929193323663	bayes_pls_golite062009
molecular transducer activity	1.69929193323663	bayes_pls_golite062009
two-component sensor activity	1.04056461630036	bayes_pls_golite062009
protein histidine kinase activity	1.02030162755071	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	0.9638866936462	bayes_pls_golite062009
cyclase activity	0.0777857375349	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [846-1105]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQAAAHSERA AMSLDEQWRM IKENQLMMLA HGVASPRIPE ARNLWLISLK LWSCEGEIID  60
   61 EQTFRRSFSD PALSHALDRR VFHEFFQQAA KAVASKGISI SLPLSVAGLS SATLVNDLLE 120
  121 QLENSPLPPR LLHLIIPAEA ILDHAESVQK LRLAGCRIVL SQVGRDLQIF NSLKANMADY 180
  181 LLLDGELCAN VQGNLMDEML ITIIQGHAQR LGMKTIAGPV VLPLVMDTLS GIGVDLIYGE 240
  241 VIADAQPLDL LVNSSYFAIN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.0
Match:	2r6oA
Description:	No description for 2r6oA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: