YRC Public Data Repository - Protein Structure Prediction

Protein:	YDEP_ECOLI
Organism:	Escherichia coli
Length:	759 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YDEP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|78044647, gi\|... - gi\|78044647\|ref\|YP_359587.1\| NAD-dependent formate dehydrogenase, alpha subunit, selenocysteine-cont...	680.0	[0..18]	[757..198]
FDHA_METJA - Formate dehydrogenase alpha chain - Methanococcus jannaschii	676.0	[0..43]	[757..4]
gi\|15669895 - gi\|15669895\|ref\|NP_248356.1\| formate dehydrogenase [Methanocaldococcus jannaschii DSM 2661]	671.0	[0..43]	[757..4]
gi\|28900814, gi\|... - gi\|28900814\|ref\|NP_800469.1\| putative formate dehydrogenase oxidoreductase protein [Vibrio parahaemo... gi\|28809260 - gi\|28809260\|dbj\|BAC62302.1\| putative formate dehydrogenase oxidoreductase protein [Vibrio parahaemol...	665.0	[0..2]	[758..4]
gi\|68213417, gi\|... - gi\|91774694\|ref\|YP_544450.1\| oxidoreductase alpha (molybdopterin) subunit [Methylobacillus flagellat...	664.0	[0..2]	[758..5]
gi\|1279770 - gi\|1279770\|gb\|AAC44820.1\| FdhA	662.0	[0..43]	[757..4]
gi\|91190553, gi\|... - gi\|91224665\|ref\|ZP_01259926.1\| putative formate dehydrogenase oxidoreductase protein [Vibrio alginol...	661.0	[0..2]	[758..4]
gi\|84393014, gi\|... - gi\|84393014\|ref\|ZP_00991781.1\| putative formate dehydrogenase oxidoreductase protein [Vibrio splendi...	660.0	[0..2]	[758..4]
gi\|110622188, gi... - gi\|147919468\|ref\|YP_686792.1\| formate dehydrogenase, alpha subunit [uncultured methanogenic archaeon...	659.0	[0..45]	[758..6]

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Predicted Domain #1

Region A:
Residues: [1-759]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKKIESYQG AAGGWGAVKS VANAVRKQMD IRQDVIAMFD MNKPEGFDCP GCAWPDPKHS  60
   61 ASFDICENGA KAIAWEVTDK QVNASFFAEN TVQSLLTWGD HELEAAGRLT QPLKYDAVSD 120
  121 CYKPLSWQQA FDEIGARLQS YSDPNQVEFY TSGRTSNEAA FLYQLFAREY GSNNFPDCSN 180
  181 MCHEPTSVGL AASIGVGKGT VLLEDFEKCD LVICIGHNPG TNHPRMLTSL RALVKRGAKM 240
  241 IAINPLQERG LERFTAPQNP FEMLTNSETQ LASAYYNVRI GGDMALLKGM MRLLIERDDA 300
  301 ASAAGRPSLL DDEFIQTHTV GFDELRRDVL NSEWKDIERI SGLSQTQIAE LADAYAAAER 360
  361 TIICYGMGIT QHEHGTQNVQ QLVNLLLMKG NIGKPGAGIC PLRGHSNVQG DRTVGITEKP 420
  421 SAEFLARLGE RYGFTPPHAP GHAAIASMQA ICTGQARALI CMGGNFALAM PDREASAVPL 480
  481 TQLDLAVHVA TKLNRSHLLT ARHSYILPVL GRSEIDMQKN GAQAVTVEDS MSMIHASRGV 540
  541 LKPAGVMLKS ECAVVAGIAQ AALPQSVVAW EYLVEDYDRI RNDIEAVLPE FADYNQRIRH 600
  601 PGGFHLINAA AERRWMTPSG KANFITSKGL LEDPSSAFNS KLVMATVRSH DQYNTTIYGM 660
  661 DDRYRGVFGQ RDVVFMSAKQ AKICRVKNGE RVNLIALTPD GKRSSRRMDR LKVVIYPMAD 720
  721 RSLVTYFPES NHMLTLDNHD PLSGIPGYKS IPVELEPSN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	171.0
Match:	1aa6A
Description:	REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.30919920906387	bayes_pls_golite062009
oxidoreductase activity	1.30667590462936	bayes_pls_golite062009
carbon-carbon lyase activity	0.209017651654353	bayes_pls_golite062009
lyase activity	0.206444192031807	bayes_pls_golite062009
carboxy-lyase activity	0.172476603894781	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: