YRC Public Data Repository - Protein Structure Prediction

Protein:	UXUA_ECOLI
Organism:	Escherichia coli
Length:	394 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UXUA_ECOLI.

Description	E-value	Query Range	Subject Range
UXUA_MANSM - Mannonate dehydratase OS=Mannheimia succiniciproducens (strain MBEL55E) GN=uxuA PE=3 SV=1	447.0	[0..1]	[394..1]
gi\|150839560, gi... - gi\|75430034\|ref\|ZP_00732591.1\| Mannonate dehydratase [Actinobacillus succinogenes 130Z], gi\|74276750...	438.0	[0..1]	[394..1]
UXUA_HAEI8 - Mannonate dehydratase OS=Haemophilus influenzae (strain 86-028NP) GN=uxuA PE=3 SV=1 gi\|42629237 - gi\|42629237\|ref\|ZP_00154785.1\| COG1312: D-mannonate dehydratase [Haemophilus influenzae R2846]	435.0	[0..1]	[394..1]
UXUA_VIBVU - Mannonate dehydratase OS=Vibrio vulnificus (strain CMCP6) GN=uxuA PE=3 SV=1 UXUA_VIBVU - Mannonate dehydratase OS=Vibrio vulnificus GN=uxuA PE=3 SV=1	434.0	[0..1]	[394..1]
gi\|42632024 - gi\|42632024\|ref\|ZP_00157562.1\| COG1312: D-mannonate dehydratase [Haemophilus influenzae R2866] gi\|145639656, gi... - gi\|145639656\|ref\|ZP_01795259.1\| mannonate dehydratase [Haemophilus influenzae PittII], gi\|145271213\|...	433.0	[0..1]	[394..1]
gi\|37201793, gi\|... - gi\|37677248\|ref\|NP_937644.1\| mannonate dehydratase [Vibrio vulnificus YJ016], gi\|37201793\|dbj\|BAC976...	432.0	[0..1]	[394..4]
UXUA_HISS2 - Mannonate dehydratase OS=Histophilus somni (strain 2336) GN=uxuA PE=3 SV=1	431.0	[0..1]	[393..1]
gi\|227838018, gi... - gi\|227885189\|ref\|ZP_04002994.1\| mannonate dehydratase [Escherichia coli 83972], gi\|227838018\|gb\|EEJ4... UXUA_ECOSM - Mannonate dehydratase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=uxuA PE=3 SV=1 UXUA_ECO45 - Mannonate dehydratase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=uxuA PE=3 SV=1 UXUA_SHIFL - Mannonate dehydratase OS=Shigella flexneri GN=uxuA PE=3 SV=1 UXUA_ECOL6 - Mannonate dehydratase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=uxuA PE=3 SV... gi\|52420907, gi\|... - gi\|52420907\|emb\|CAH55786.1\| mannonate hydrolase [Escherichia coli], gi\|209749284\|gb\|ACI72949.1\| mann... gi\|194437717, gi... - gi\|83586653\|ref\|ZP_00925285.1\| COG1312: D-mannonate dehydratase [Escherichia coli 101-1], gi\|1944377... UXUA_ECOL6 - Mannonate dehydratase OS=Escherichia coli O6 GN=uxuA PE=3 SV=1 gi\|56480539, gi\|... - gi\|56480539\|ref\|NP_709912.2\| mannonate dehydratase [Shigella flexneri 2a str. 301], gi\|56384090\|gb\|A... gi\|75242244, gi\|... - gi\|75242244\|ref\|ZP_00726006.1\| COG1312: D-mannonate dehydratase [Escherichia coli F11], gi\|191170821... gi\|75235104, gi\|... - gi\|75235104\|ref\|ZP_00719360.1\| COG1312: D-mannonate dehydratase [Escherichia coli E110019], gi\|19307... gi\|191167119, gi... - gi\|75229720\|ref\|ZP_00716253.1\| COG1312: D-mannonate dehydratase [Escherichia coli B7A], gi\|191167119... UXUA_ECOUT - Mannonate dehydratase OS=Escherichia coli (strain UTI89 / UPEC) GN=uxuA PE=3 SV=1 UXUA_ECOHS - Mannonate dehydratase OS=Escherichia coli O9:H4 (strain HS) GN=uxuA PE=3 SV=1 UXUA_ECOL5 - Mannonate dehydratase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=uxuA PE=3 SV=1 UXUA_ECO24 - Mannonate dehydratase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=uxuA PE=3 SV=1 UXUA_SHIF8 - Mannonate dehydratase OS=Shigella flexneri serotype 5b (strain 8401) GN=uxuA PE=3 SV=1 UXUA_ECOK1 - Mannonate dehydratase OS=Escherichia coli O1:K1 / APEC GN=uxuA PE=3 SV=1	430.0	[0..1]	[394..1]
gi\|30065422, gi\|... - gi\|30065422\|ref\|NP_839593.1\| mannonate dehydratase [Shigella flexneri 2a str. 2457T], gi\|30043684\|gb...	430.0	[0..1]	[394..1]

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Predicted Domain #1

Region A:
Residues: [1-394]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQTWRWYGP NDPVSLADVR QAGATGVVTA LHHIPNGEVW SVEEILKRKA IIEDAGLVWS  60
   61 VVESVPIHED IKTHTGNYEQ WIANYQQTLR NLAQCGIRTV CYNFMPVLDW TRTDLEYVLP 120
  121 DGSKALRFDQ IEFAAFEMHI LKRPGAEADY TEEEIAQAAE RFATMSDEDK ARLTRNIIAG 180
  181 LPGAEEGYTL DQFRKHLELY KDIDKAKLRE NFAVFLKAII PVAEEVGVRM AVHPDDPPRP 240
  241 ILGLPRIVST IEDMQWMVDT VNSMANGFTM CTGSYGVRAD NDLVDMIKQF GPRIYFTHLR 300
  301 STMREDNPKT FHEAAHLNGD VDMYEVVKAI VEEEHRRKAE GKEDLIPMRP DHGHQMLDDL 360
  361 KKKTNPGYSA IGRLKGLAEV RGVELAIQRA FFSR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.154902
Match:	1tz9A
Description:	Crystal Structure of the Putative Mannonate Dehydratase from Enterococcus faecalis, Northeast Structural Genomics Target EfR41
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.66019571685402	bayes_pls_golite062009
mannonate dehydratase activity	0.869450128395451	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	0.4123141600891	bayes_pls_golite062009
intramolecular oxidoreductase activity	0.14803442727167	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: