YRC Public Data Repository - Protein Structure Prediction

Protein:	TRPC_ECOLI
Organism:	Escherichia coli
Length:	452 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRPC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|56413350, gi\|... - gi\|56413350\|ref\|YP_150425.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran... gi\|197362275, gi... - gi\|197362275\|ref\|YP_002141912.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylant...	555.0	[0..1]	[452..1]
gi\|62127924, gi\|... - gi\|62180291\|ref\|YP_216708.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran...	555.0	[0..1]	[452..1]
TRPC_SALTY - Tryptophan biosynthesis protein trpCF OS=Salmonella typhimurium GN=trpC PE=3 SV=1 TRPC_SALTY - Tryptophan biosynthesis protein TrpCF OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720... gi\|205325057, gi... - gi\|205325057\|gb\|EDZ12896.1\| tryptophan biosynthesis protein trpCF [Salmonella enterica subsp. enteri... lcl\|NC_016856.1_... - [gene=trpC] [protein=bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate is... TRPC_SALTY - Tryptophan biosynthesis protein TrpCF OS=Salmonella typhimurium GN=trpC PE=3 SV=1	554.0	[0..1]	[452..1]
TRPC_SALTI - Tryptophan biosynthesis protein trpCF OS=Salmonella typhi GN=trpC PE=3 SV=1 gi\|213424440 - gi\|213424440\|ref\|ZP_03357253.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanth... gi\|16760156 - gi\|16760156\|ref\|NP_455773.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran... TRPC_SALTI - Tryptophan biosynthesis protein TrpCF OS=Salmonella typhi GN=trpC PE=3 SV=1 gi\|29142073, gi\|... - gi\|29142073\|ref\|NP_805415.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran...	552.0	[0..1]	[452..1]
gi\|218365016, gi... - gi\|218558247\|ref\|YP_002391160.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylant... gi\|117623523, gi... - gi\|117623523\|ref\|YP_852436.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthra... gi\|237705286, gi... - gi\|237705286\|ref\|ZP_04535767.1\| anthranilate isomerase [Escherichia sp. 3_2_53FAA], gi\|226900043\|gb\|... gi\|91072128, gi\|... - gi\|91210554\|ref\|YP_540540.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran...	550.0	[0..1]	[452..1]
gi\|775166 - gi\|775166\|gb\|AAB60039.1\| anthranilate isomerase	549.0	[0..1]	[452..1]
gi\|54309653, gi\|... - gi\|54309653\|ref\|YP_130673.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran...	547.0	[0..1]	[452..1]
gi\|191171056, gi... - gi\|75242062\|ref\|ZP_00725856.1\| COG0134: Indole-3-glycerol phosphate synthase [Escherichia coli F11],...	546.0	[0..1]	[452..2]

Back

Predicted Domain #1

Region A:
Residues: [1-452]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTVLAKIVA DKAIWVEARK QQQPLASFQN EVQPSTRHFY DALQGARTAF ILECKKASPS  60
   61 KGVIRDDFDP ARIAAIYKHY ASAISVLTDE KYFQGSFNFL PIVSQIAPQP ILCKDFIIDP 120
  121 YQIYLARYYQ ADACLLMLSV LDDDQYRQLA AVAHSLEMGV LTEVSNEEEQ ERAIALGAKV 180
  181 VGINNRDLRD LSIDLNRTRE LAPKLGHNVT VISESGINTY AQVRELSHFA NGFLIGSALM 240
  241 AHDDLHAAVR RVLLGENKVC GLTRGQDAKA AYDAGAIYGG LIFVATSPRC VNVEQAQEVM 300
  301 AAAPLQYVGV FRNHDIADVV DKAKVLSLAA VQLHGNEEQL YIDTLREALP AHVAIWKALS 360
  361 VGETLPAREF QHVDKYVLDN GQGGSGQRFD WSLLNGQSLG NVLLAGGLGA DNCVEAAQTG 420
  421 CAGLDFNSAV ESQPGIKDAR LLASVFQTLR AY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	155.0
Match:	1piiA
Description:	THREE-DIMENSIONAL STRUCTURE OF THE BIFUNCTIONAL ENZYME PHOSPHORIBOSYLANTHRANILATE ISOMERASE: INDOLEGLYCEROLPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI REFINED AT 2.0 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
tryptophan synthase activity	3.15663465352598	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	3.12120866545322	bayes_pls_golite062009
catalytic activity	2.81275055404078	bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity	2.655130814615	bayes_pls_golite062009
carbon-carbon lyase activity	2.44001937916931	bayes_pls_golite062009
carboxy-lyase activity	1.80978905789979	bayes_pls_golite062009
lyase activity	0.9228652996943	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.82314869965119	bayes_pls_golite062009
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	0.302746738903759	bayes_pls_golite062009
isomerase activity	0.14149405165663	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: