YRC Public Data Repository - Protein Structure Prediction

Protein:	TLDD_ECOLI
Organism:	Escherichia coli
Length:	481 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TLDD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|13363590, gi\|... - gi\|15833371\|ref\|NP_312144.1\| protease TldD [Escherichia coli O157:H7 str. Sakai], gi\|13363590\|dbj\|BA... gi\|208741377, gi... - gi\|208821254\|ref\|ZP_03261574.1\| protein TldD [Escherichia coli O157:H7 str. EC4042], gi\|208741377\|gb... gi\|209398830, gi... - gi\|209398830\|ref\|YP_002272707.1\| protein TldD [Escherichia coli O157:H7 str. EC4115], gi\|209160230\|g... gi\|217327293, gi... - gi\|217327293\|ref\|ZP_03443376.1\| protein TldD [Escherichia coli O157:H7 str. TW14588], gi\|217319660\|g... gi\|168786130, gi... - gi\|189374193\|gb\|EDU92609.1\| protein TldD [Escherichia coli O157:H7 str. EC869], gi\|168786130\|ref\|ZP_... gi\|254795187, gi... - gi\|254795187\|ref\|YP_003080024.1\| predicted peptidase [Escherichia coli O157:H7 str. TW14359], gi\|254... gi\|195939442 - gi\|195939442\|ref\|ZP_03084824.1\| protease TldD [Escherichia coli O157:H7 str. EC4024] gi\|208728915, gi... - gi\|208809114\|ref\|ZP_03251451.1\| protein TldD [Escherichia coli O157:H7 str. EC4206], gi\|208728915\|gb... gi\|208813250, gi... - gi\|208813250\|ref\|ZP_03254579.1\| protein TldD [Escherichia coli O157:H7 str. EC4045], gi\|208734527\|gb... gi\|189366121, gi... - gi\|189366121\|gb\|EDU84537.1\| protein TldD [Escherichia coli O157:H7 str. EC4501], gi\|168763781\|ref\|ZP... gi\|168769100, gi... - gi\|189361766\|gb\|EDU80185.1\| protein TldD [Escherichia coli O157:H7 str. EC4486], gi\|168769100\|ref\|ZP... gi\|187767170, gi... - gi\|187767170\|gb\|EDU31014.1\| protein TldD [Escherichia coli O157:H7 str. EC4196], gi\|168777639\|ref\|ZP... gi\|189001089, gi... - gi\|189001089\|gb\|EDU70075.1\| protein TldD [Escherichia coli O157:H7 str. EC4076], gi\|168781388\|ref\|ZP... gi\|25305200, gi\|... - pir\|\|H85988 suppresses inhibitory activity of CsrA [imported] - Escherichia coli (strain O157:H7, su... gi\|15803778, gi\|... - gi\|15803778\|ref\|NP_289812.1\| protease TldD [Escherichia coli O157:H7 EDL933], gi\|12517868\|gb\|AAG5837... gi\|188013929, gi... - gi\|188013929\|gb\|EDU52051.1\| protein TldD [Escherichia coli O157:H7 str. EC4113], gi\|168752143\|ref\|ZP... gi\|13363590, gi\|... - gi\|15833371\|ref\|NP_312144.1\| suppresses inhibitory activity of CsrA [Escherichia coli O157:H7], gi\|1... gi\|168754226, gi... - gi\|189358715\|gb\|EDU77134.1\| protein TldD [Escherichia coli O157:H7 str. EC4401], gi\|168754226\|ref\|ZP...	547.0	[0..1]	[481..1]
gi\|90311123, gi\|... - gi\|90407763\|ref\|ZP_01215941.1\| TldD protein [Psychromonas sp. CNPT3], gi\|90311123\|gb\|EAS39230.1\| Tld...	547.0	[0..1]	[480..1]
gi\|82778552, gi\|... - gi\|82778552\|ref\|YP_404901.1\| protease TldD [Shigella dysenteriae Sd197], gi\|81242700\|gb\|ABB63410.1\| ...	546.0	[0..1]	[481..1]
gi\|73857251, gi\|... - gi\|74313774\|ref\|YP_312193.1\| protease TldD [Shigella sonnei Ss046], gi\|73857251\|gb\|AAZ89958.1\| suppr...	546.0	[0..1]	[481..1]
gi\|109698802, gi... - gi\|109896521\|ref\|YP_659776.1\| peptidase U62, modulator of DNA gyrase [Pseudoalteromonas atlantica T6...	545.0	[0..1]	[481..1]
gi\|62129509, gi\|... - gi\|62181876\|ref\|YP_218293.1\| protease TldD [Salmonella enterica subsp. enterica serovar Choleraesuis...	545.0	[0..1]	[481..35]
gi\|81246937, gi\|... - gi\|82545526\|ref\|YP_409473.1\| protease TldD [Shigella boydii Sb227], gi\|81246937\|gb\|ABB67645.1\| suppr...	545.0	[0..1]	[481..1]
gi\|213418104 - gi\|213418104\|ref\|ZP_03351173.1\| protease TldD [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213428315 - gi\|213428315\|ref\|ZP_03361065.1\| protease TldD [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213586679 - gi\|213586679\|ref\|ZP_03368505.1\| protease TldD [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213648440 - gi\|213648440\|ref\|ZP_03378493.1\| protease TldD [Salmonella enterica subsp. enterica serovar Typhi str... gi\|25305220, gi\|... - gi\|25305220\|pir\|\|AE0911 TldD protein [imported] - Salmonella enterica subsp. enterica serovar Typhi ... gi\|194711477, gi... - gi\|194735975\|ref\|YP_002116316.1\| protein TldD [Salmonella enterica subsp. enterica serovar Schwarzen... gi\|16766663, gi\|... - gi\|16766663\|ref\|NP_462278.1\| protease TldD [Salmonella typhimurium LT2], gi\|16421928\|gb\|AAL22237.1\| ... gi\|197265231, gi... - gi\|197265231\|ref\|ZP_03165305.1\| protein TldD [Salmonella enterica subsp. enterica serovar Saintpaul ... gi\|204319962, gi... - gi\|204931195\|ref\|ZP_03221989.1\| protein TldD [Salmonella enterica subsp. enterica serovar Javiana st... gi\|213160818 - gi\|213160818\|ref\|ZP_03346528.1\| protease TldD [Salmonella enterica subsp. enterica serovar Typhi str... gi\|29143616, gi\|... - gi\|29143616\|ref\|NP_806958.1\| protease TldD [Salmonella enterica subsp. enterica serovar Typhi str. T... gi\|167993952, gi... - gi\|205328098\|gb\|EDZ14862.1\| protein TldD [Salmonella enterica subsp. enterica serovar 4,[5],12:i:- s... gi\|16762127 - gi\|16762127\|ref\|NP_457744.1\| protease TldD [Salmonella enterica subsp. enterica serovar Typhi str. C... gi\|168239393, gi... - gi\|197287903\|gb\|EDY27291.1\| protein TldD [Salmonella enterica subsp. enterica serovar Schwarzengrund... gi\|229037905 - gi\|229037905\|ref\|YP_218293.2\| protease TldD [Salmonella enterica subsp. enterica serovar Choleraesui... gi\|238913552 - gi\|238913552\|ref\|ZP_04657389.1\| protease TldD [Salmonella enterica subsp. enterica serovar Tennessee... lcl\|NC_016856.1_... - [gene=tldD] [protein=protease TldD] [protein_id=YP_005239554.1] [location=complement(3548249..354969... gi\|224469693, gi... - gi\|224585165\|ref\|YP_002638964.1\| TldD protein [Salmonella enterica subsp. enterica serovar Paratyphi...	545.0	[0..1]	[481..1]
gi\|205322509, gi... - gi\|205322509\|gb\|EDZ10348.1\| protein TldD [Salmonella enterica subsp. enterica serovar Saintpaul str.... gi\|56129552, gi\|... - gi\|56415295\|ref\|YP_152370.1\| protease TldD [Salmonella enterica subsp. enterica serovar Paratyphi A ... gi\|197095702, gi... - gi\|197364225\|ref\|YP_002143862.1\| protease TldD [Salmonella enterica subsp. enterica serovar Paratyph...	544.0	[0..1]	[481..1]
gi\|71280464, gi\|... - gi\|71280464\|ref\|YP_271201.1\| tldD protein [Colwellia psychrerythraea 34H], gi\|71146204\|gb\|AAZ26677.1...	544.0	[0..3]	[480..1]

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Predicted Domain #1

Region A:
Residues: [1-481]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNLVSEQL LAANGLKHQD LFAILGQLAE RRLDYGDLYF QSSYHESWVL EDRIIKDGSY  60
   61 NIDQGVGVRA ISGEKTGFAY ADQISLLALE QSAQAARTIV RDSGDGKVQT LGAVEHSPLY 120
  121 TSVDPLQSMS REEKLDILRR VDKVAREADK RVQEVTASLS GVYELILVAA TDGTLAADVR 180
  181 PLVRLSVSVL VEEDGKRERG ASGGGGRFGY EFFLADLDGE VRADAWAKEA VRMALVNLSA 240
  241 VAAPAGTMPV VLGAGWPGVL LHEAVGHGLE GDFNRRGTSV FSGQVGELVA SELCTVVDDG 300
  301 TMVDRRGSVA IDDEGTPGQY NVLIENGILK GYMQDKLNAR LMGMTPTGNG RRESYAHLPM 360
  361 PRMTNTYMLP GKSTPQEIIE SVEYGIYAPN FGGGQVDITS GKFVFSTSEA YLIENGKVTK 420
  421 PVKGATLIGS GIETMQQISM VGNDLKLDNG VGVCGKEGQS LPVGVGQPTL KVDNLTVGGT 480
  481 A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.522879
Match:	1vl4A
Description:	Crystal structure of PMBA-related protein (TM0727) from Thermotoga maritima at 1.95 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	0.844669254385544	bayes_pls_golite062009
catalytic activity	0.55839241827268	bayes_pls_golite062009
transcription repressor activity	0.0121152486203551	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: