YRC Public Data Repository - Protein Structure Prediction

Protein:	THIL_ECOLI
Organism:	Escherichia coli
Length:	325 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THIL_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|2329840 - gi\|2329840\|dbj\|BAA21778.1\| thiamine-monophosphate kinase [Escherichia coli]	320.0	[0..1]	[325..1]
gi\|124500209, gi... - gi\|124528872\|ref\|ZP_01700057.1\| thiamine-monophosphate kinase [Escherichia coli B], gi\|124500209\|gb\|... gi\|170021211, gi... - gi\|170021211\|ref\|YP_001726165.1\| thiamine monophosphate kinase [Escherichia coli ATCC 8739], gi\|1697... gi\|218350609, gi... - gi\|218693877\|ref\|YP_002401544.1\| thiamine monophosphate kinase [Escherichia coli 55989], gi\|21835060... gi\|75230142, gi\|... - gi\|75230142\|ref\|ZP_00716646.1\| COG0611: Thiamine monophosphate kinase [Escherichia coli B7A], gi\|191... gi\|75189484, gi\|... - gi\|75189484\|ref\|ZP_00702751.1\| COG0611: Thiamine monophosphate kinase [Escherichia coli E24377A], gi... gi\|74310986, gi\|... - gi\|74310986\|ref\|YP_309405.1\| thiamine monophosphate kinase [Shigella sonnei Ss046], gi\|73854463\|gb\|A... gi\|188488867, gi... - gi\|75512478\|ref\|ZP_00735017.1\| COG0611: Thiamine monophosphate kinase [Escherichia coli 53638], gi\|1...	320.0	[0..1]	[325..1]
gi\|82542905, gi\|... - gi\|82542905\|ref\|YP_406852.1\| thiamine monophosphate kinase [Shigella boydii Sb227], gi\|81244316\|gb\|A...	319.0	[0..1]	[325..1]
gi\|81239826, gi\|... - gi\|82775678\|ref\|YP_402025.1\| thiamine monophosphate kinase [Shigella dysenteriae Sd197], gi\|81239826...	319.0	[0..1]	[325..1]
gi\|62126663, gi\|... - gi\|62179030\|ref\|YP_215447.1\| thiamine monophosphate kinase [Salmonella enterica subsp. enterica sero... gi\|224582257, gi... - gi\|224582257\|ref\|YP_002636055.1\| thiamine monophosphate kinase [Salmonella enterica subsp. enterica ... gi\|199601921, gi... - gi\|200389476\|ref\|ZP_03216087.1\| thiamine-monophosphate kinase [Salmonella enterica subsp. enterica s... gi\|194469039, gi... - gi\|194469039\|ref\|ZP_03075023.1\| thiamine-monophosphate kinase [Salmonella enterica subsp. enterica s... gi\|168232392, gi... - gi\|205333460\|gb\|EDZ20224.1\| thiamine-monophosphate kinase [Salmonella enterica subsp. enterica serov... gi\|238911448 - gi\|238911448\|ref\|ZP_04655285.1\| thiamine monophosphate kinase [Salmonella enterica subsp. enterica s...	318.0	[0..1]	[325..1]
gi\|193065181, gi... - gi\|75256789\|ref\|ZP_00728394.1\| COG0611: Thiamine monophosphate kinase [Escherichia coli E22], gi\|193... gi\|192958032, gi... - gi\|75237201\|ref\|ZP_00721248.1\| COG0611: Thiamine monophosphate kinase [Escherichia coli E110019], gi... gi\|194428856, gi... - gi\|75209973\|ref\|ZP_00710162.1\| COG0611: Thiamine monophosphate kinase [Escherichia coli B171], gi\|19... gi\|157065618, gi... - gi\|75194636\|ref\|ZP_00704706.1\| COG0611: Thiamine monophosphate kinase [Escherichia coli HS], gi\|1571... gi\|218359748, gi... - gi\|218552980\|ref\|YP_002385893.1\| thiamine monophosphate kinase [Escherichia coli IAI1], gi\|218359748... gi\|209910889, gi... - gi\|209917630\|ref\|YP_002291714.1\| thiamine monophosphate kinase [Escherichia coli SE11], gi\|209910889...	318.0	[0..1]	[325..1]
gi\|30040156, gi\|... - gi\|30061912\|ref\|NP_836083.1\| thiamine monophosphate kinase [Shigella flexneri 2a str. 2457T], gi\|300... gi\|24111795, gi\|... - gi\|24111795\|ref\|NP_706305.1\| thiamine monophosphate kinase [Shigella flexneri 2a str. 301], gi\|24050...	317.0	[0..1]	[325..1]
gi\|208815172, gi... - gi\|208815172\|ref\|ZP_03256351.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4045]... gi\|208807129, gi... - gi\|208807129\|ref\|ZP_03249466.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4206]... gi\|254791600, gi... - gi\|254791600\|ref\|YP_003076437.1\| thiamin-monophosphate kinase [Escherichia coli O157:H7 str. TW14359... gi\|195938518 - gi\|195938518\|ref\|ZP_03083900.1\| thiamine monophosphate kinase [Escherichia coli O157:H7 str. EC4024] gi\|189377405, gi... - gi\|189377405\|gb\|EDU95821.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC508], gi\|... gi\|13359927, gi\|... - gi\|15829724\|ref\|NP_308497.1\| thiamine monophosphate kinase [Escherichia coli O157:H7 str. Sakai], gi... gi\|217322846, gi... - gi\|217326625\|ref\|ZP_03442709.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. TW14588... THIL_ECO57 - Thiamine-monophosphate kinase OS=Escherichia coli O157:H7 GN=thiL PE=3 SV=1 gi\|209398517, gi... - gi\|209398517\|ref\|YP_002269061.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4115... gi\|209744062, gi... - pir\|\|B85538 thiamin-monophosphate kinase [imported] - Escherichia coli (strain O157:H7, substrain E... gi\|208823187, gi... - gi\|208823187\|ref\|ZP_03263505.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4042]... gi\|168761620, gi... - gi\|189367987\|gb\|EDU86403.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4501], gi... gi\|12513272, gi\|... - gi\|15800146\|ref\|NP_286158.1\| thiamine monophosphate kinase [Escherichia coli O157:H7 EDL933], gi\|125... gi\|168756956, gi... - gi\|189356006\|gb\|EDU74425.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4401], gi... gi\|188015839, gi... - gi\|188015839\|gb\|EDU53961.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4113], gi... gi\|168786261, gi... - gi\|189373502\|gb\|EDU91918.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC869], gi\|... gi\|168783280, gi... - gi\|188999392\|gb\|EDU68378.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4076], gi... gi\|187768294, gi... - gi\|187768294\|gb\|EDU32138.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4196], gi... gi\|189362350, gi... - gi\|189362350\|gb\|EDU80769.1\| thiamine-monophosphate kinase [Escherichia coli O157:H7 str. EC4486], gi...	317.0	[0..1]	[325..1]
gi\|83570315, gi\|... - gi\|83570315\|ref\|ZP_00921760.1\| COG0611: Thiamine monophosphate kinase [Shigella dysenteriae 1012], g...	317.0	[0..1]	[325..1]
gi\|36787188, gi\|... - gi\|37527752\|ref\|NP_931097.1\| thiamine monophosphate kinase [Photorhabdus luminescens subsp. laumondi...	316.0	[0..1]	[322..1]

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Predicted Domain #1

Region A:
Residues: [1-325]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MACGEFSLIA RYFDRVRSSR LDVELGIGDD CALLNIPEKQ TLAISTDTLV AGNHFLPDID  60
   61 PADLAYKALA VNLSDLAAMG ADPAWLTLAL TLPDVDEAWL ESFSDSLFDL LNYYDMQLIG 120
  121 GDTTRGPLSM TLGIHGFVPM GRALTRSGAK PGDWIYVTGT PGDSAAGLAI LQNRLQVADA 180
  181 KDADYLIKRH LRPSPRILQG QALRDLANSA IDLSDGLISD LGHIVKASDC GARIDLALLP 240
  241 FSDALSRHVE PEQALRWALS GGEDYELCFT VPELNRGALD VALGHLGVPF TCIGQMTADI 300
  301 EGLCFIRDGE PVTLDWKGYD HFATP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.09691
Match:	1vqvA
Description:	Crystal Structure of Thiamine Monophosphate Kinase (thil) from Aquifex Aeolicus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cyclo-ligase activity	1.67600601239753	bayes_pls_golite062009
thiamin phosphate kinase activity	1.53327197207868	bayes_pls_golite062009
catalytic activity	0.687693392934177	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	0.63318404518052	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: