YRC Public Data Repository - Protein Structure Prediction

Protein:	THIG_ECOLI
Organism:	Escherichia coli
Length:	256 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THIG_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|1256589 - gi\|1256589\|gb\|AAA96395.1\| N-terminal and C-terminal ends are similar to the proteins ThiG and D-amin...	272.0	[0..1]	[253..397]
gi\|37200139, gi\|... - gi\|37681387\|ref\|NP_935996.1\| thiazole synthase [Vibrio vulnificus YJ016], gi\|37200139\|dbj\|BAC95967.1...	271.0	[0..1]	[253..55]
gi\|23129911, gi\|... - gi\|23129911\|ref\|ZP_00111732.1\| COG0665: Glycine/D-amino acid oxidases (deaminating) [Nostoc punctifo...	270.0	[0..2]	[252..415]
THIG_GEOKA - Thiazole synthase OS=Geobacillus kaustophilus GN=thiG PE=3 SV=1 THIG_GEOKA - Thiazole synthase OS=Geobacillus kaustophilus (strain HTA426) GN=thiG PE=3 SV=1	270.0	[0..1]	[251..3]
THIOG_ANAVT - Bifunctional protein ThiO/ThiG OS=Anabaena variabilis (strain ATCC 29413 / PCC 7937) GN=thiO/thiG PE...	270.0	[0..2]	[253..394]
gi\|118581875, gi... - gi\|71836233\|ref\|ZP_00676002.1\| Thiazole biosynthesis [Pelobacter propionicus DSM 2379], gi\|71743063\|...	270.0	[0..2]	[253..6]
gi\|110547418, gi... - gi\|222054684\|ref\|YP_002537046.1\| thiazole biosynthesis family protein [Geobacter sp. FRC-32], gi\|221...	268.0	[0..2]	[253..7]
THIOG_NOSS1 - Bifunctional protein ThiO/ThiG OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=thiO/thiG PE=3 SV=1 gi\|25534633 - pir\|\|AH2245 thiamin biosynthesis protein [imported] - Nostoc sp. (strain PCC 7120)	268.0	[0..2]	[253..394]
THIG_GEOUR - Thiazole synthase OS=Geobacter uraniireducens (strain Rf4) GN=thiG PE=3 SV=1	267.0	[0..2]	[253..8]

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Predicted Domain #1

Region A:
Residues: [1-256]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRIADKTFD SHLFTGTGKF ASSQLMVEAI RASGSQLVTL AMKRVDLRQH NDAILEPLIA  60
   61 AGVTLLPNTS GAKTAEEAIF AAHLAREALG TNWLKLEIHP DARWLLPDPI ETLKAAETLV 120
  121 QQGFVVLPYC GADPVLCKRL EEVGCAAVMP LGAPIGSNQG LETRAMLEII IQQATVPVVV 180
  181 DAGIGVPSHA AQALEMGADA VLVNTAIAVA DDPVNMAKAF RLAVEAGLLA RQSGPGSRSY 240
  241 FAHATSPLTG FLEASA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.69897
Match:	1tygA
Description:	Structure of the thiazole synthase/ThiS complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.00494578069019	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: