YRC Public Data Repository - Protein Structure Prediction

Protein:	SYC_ECOLI
Organism:	Escherichia coli
Length:	461 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|68547081, gi\|... - gi\|68547081\|ref\|ZP_00586622.1\| Cysteinyl-tRNA synthetase, class Ia [Shewanella amazonensis SB2B], gi...	442.0	[0..1]	[461..195]
SYC_SHELP - Cysteine--tRNA ligase OS=Shewanella loihica (strain ATCC BAA-1088 / PV-4) GN=cysS PE=3 SV=1	439.0	[0..1]	[461..1]
SYC_HAEI8 - Cysteine--tRNA ligase OS=Haemophilus influenzae (strain 86-028NP) GN=cysS PE=3 SV=1	437.0	[0..1]	[461..1]
gi\|37198290, gi\|... - gi\|37679546\|ref\|NP_934155.1\| cysteinyl-tRNA synthetase [Vibrio vulnificus YJ016], gi\|37198290\|dbj\|BA...	436.0	[0..1]	[461..50]
gi\|77958384 - gi\|77958384\|ref\|ZP_00822418.1\| COG0215: Cysteinyl-tRNA synthetase [Yersinia bercovieri ATCC 43970]	436.0	[0..1]	[461..20]
SYC_SHESW - Cysteine--tRNA ligase OS=Shewanella sp. (strain W3-18-1) GN=cysS PE=3 SV=1	436.0	[0..1]	[461..3]
gi\|166204483, gi... - gi\|166214354\|ref\|ZP_02240389.1\| cysteinyl-tRNA synthetase [Yersinia pestis biovar Antiqua str. B4200... gi\|167398585, gi... - gi\|167398585\|ref\|ZP_02304109.1\| cysteinyl-tRNA synthetase [Yersinia pestis biovar Antiqua str. UG05-... gi\|167422736, gi... - gi\|167422736\|ref\|ZP_02314489.1\| cysteinyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. MG... gi\|167423331, gi... - gi\|167423331\|ref\|ZP_02315084.1\| cysteinyl-tRNA synthetase [Yersinia pestis biovar Mediaevalis str. K... gi\|229695039, gi... - gi\|229838673\|ref\|ZP_04458832.1\| cysteinyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. PE... gi\|165927660, gi... - gi\|165927660\|ref\|ZP_02223492.1\| cysteinyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. F1... gi\|229896170, gi... - gi\|229896170\|ref\|ZP_04511340.1\| cysteinyl-tRNA synthetase [Yersinia pestis Pestoides A], gi\|22970109... gi\|165989933, gi... - gi\|166011255\|ref\|ZP_02232153.1\| cysteinyl-tRNA synthetase [Yersinia pestis biovar Antiqua str. E1979... gi\|229899240, gi... - gi\|229899240\|ref\|ZP_04514383.1\| cysteinyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. In... gi\|16123250, gi\|... - gi\|218930118\|ref\|YP_002347993.1\| cysteinyl-tRNA synthetase [Yersinia pestis CO92], gi\|16123250\|ref\|N... SYC_YERP3 - Cysteine--tRNA ligase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=cysS PE=3 SV... SYC_YERPE - Cysteine--tRNA ligase OS=Yersinia pestis GN=cysS PE=3 SV=1 SYC_YERPA - Cysteine--tRNA ligase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=cysS PE=3 SV=1 gi\|149365066, gi... - gi\|149365066\|ref\|ZP_01887101.1\| cysteinyl-tRNA synthetase [Yersinia pestis CA88-4125], gi\|149291479\|... SYC_YERPP - Cysteine--tRNA ligase OS=Yersinia pestis (strain Pestoides F) GN=cysS PE=3 SV=1 SYC_YERPN - Cysteine--tRNA ligase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=cysS PE=3 SV=1 SYC_YERPG - Cysteine--tRNA ligase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=cysS PE=3 SV=1	436.0	[0..1]	[461..1]
SO1791 - cysteinyl-tRNA synthetase SYC_SHEON - Cysteine--tRNA ligase OS=Shewanella oneidensis (strain MR-1) GN=cysS PE=3 SV=1	436.0	[0..1]	[461..1]
SYC_HAEIN - Cysteinyl-tRNA synthetase OS=Haemophilus influenzae GN=cysS PE=3 SV=1 SYC_HAEIN - Cysteine--tRNA ligase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=cysS ...	435.0	[0..1]	[461..1]
SYC_YERPS - Cysteine--tRNA ligase OS=Yersinia pseudotuberculosis GN=cysS PE=3 SV=1 SYC_YERPB - Cysteine--tRNA ligase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=cysS PE=3 SV=1 SYC_YERPS - Cysteine--tRNA ligase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=cysS PE=3 SV=1	435.0	[0..1]	[461..1]

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Predicted Domain #1

Region A:
Residues: [1-461]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKIFNTLTR QKEEFKPIHA GEVGMYVCGI TVYDLCHIGH GRTFVAFDVV ARYLRFLGYK  60
   61 LKYVRNITDI DDKIIKRANE NGESFVAMVD RMIAEMHKDF DALNILRPDM EPRATHHIAE 120
  121 IIELTEQLIA KGHAYVADNG DVMFDVPTDP TYGVLSRQDL DQLQAGARVD VVDDKRNPMD 180
  181 FVLWKMSKEG EPSWPSPWGA GRPGWHIECS AMNCKQLGNH FDIHGGGSDL MFPHHENEIA 240
  241 QSTCAHDGQY VNYWMHSGMV MVDREKMSKS LGNFFTVRDV LKYYDAETVR YFLMSGHYRS 300
  301 QLNYSEENLK QARAALERLY TALRGTDKTV APAGGEAFEA RFIEAMDDDF NTPEAYSVLF 360
  361 DMAREVNRLK AEDMAAANAM ASHLRKLSAV LGLLEQEPEA FLQSGAQADD SEVAEIEALI 420
  421 QQRLDARKAK DWAAADAARD RLNEMGIVLE DGPQGTTWRR K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	118.0
Match:	1li5A
Description:	Cysteinyl-tRNA synthetase (CysRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-oxygen bonds	7.16276509815667	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	7.16276509815667	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.13957775963187	bayes_pls_golite062009
ligase activity	6.11211476973434	bayes_pls_golite062009
cysteine-tRNA ligase activity	5.23703961447809	bayes_pls_golite062009
isoleucine-tRNA ligase activity	3.76808520367507	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.63681738794687	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
methionine-tRNA ligase activity	2.01261843164558	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.88984817882585	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.14187887833901	bayes_pls_golite062009
arginine-tRNA ligase activity	1.13743634264647	bayes_pls_golite062009
nucleotidyltransferase activity	0.2293846471193	bayes_pls_golite062009
nucleic acid binding	0.161799496958314	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.126511747475258	bayes_pls_golite062009
glutamine-tRNA ligase activity	0.118292082006187	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: