YRC Public Data Repository - Protein Structure Prediction

Protein:	SPEB_ECOLI
Organism:	Escherichia coli
Length:	306 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPEB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|227120012, gi... - gi\|75825314\|ref\|ZP_00754750.1\| COG0010: Arginase/agmatinase/formimionoglutamate hydrolase, arginase ... gi\|121628483, gi... - gi\|75814685\|ref\|ZP_00745244.1\| COG0010: Arginase/agmatinase/formimionoglutamate hydrolase, arginase ... gi\|121591148, gi... - gi\|121591148\|ref\|ZP_01678454.1\| agmatinase [Vibrio cholerae 2740-80], gi\|121546994\|gb\|EAX57138.1\| ag... gi\|124117517, gi... - gi\|153224697\|ref\|ZP_01954555.1\| agmatinase [Vibrio cholerae MAK 757], gi\|124117517\|gb\|EAY36260.1\| ag... gi\|254284448, gi... - gi\|254284448\|ref\|ZP_04959415.1\| agmatinase [Vibrio cholerae AM-19226], gi\|197753650\|ref\|YP_002177041... gi\|153827605, gi... - gi\|153827605\|ref\|ZP_01980272.1\| agmatinase [Vibrio cholerae MZO-2], gi\|149737920\|gb\|EDM52825.1\| agma... gi\|227011522, gi... - gi\|227812380\|ref\|YP_002812390.1\| agmatinase [Vibrio cholerae M66-2], gi\|227011522\|gb\|ACP07733.1\| agm... gi\|229506033, gi... - gi\|229506033\|ref\|ZP_04395542.1\| agmatinase [Vibrio cholerae BX 330286], gi\|229356384\|gb\|EEO21302.1\| ... gi\|229510111, gi... - gi\|229510111\|ref\|ZP_04399591.1\| agmatinase [Vibrio cholerae B33], gi\|229352556\|gb\|EEO17496.1\| agmati... gi\|229348228, gi... - gi\|229514248\|ref\|ZP_04403709.1\| agmatinase [Vibrio cholerae TMA 21], gi\|229348228\|gb\|EEO13186.1\| agm... gi\|229345795, gi... - gi\|229517759\|ref\|ZP_04407204.1\| agmatinase [Vibrio cholerae RC9], gi\|229345795\|gb\|EEO10768.1\| agmati... gi\|229372050, gi... - gi\|229605564\|ref\|YP_002876268.1\| agmatinase [Vibrio cholerae MJ-1236], gi\|229372050\|gb\|ACQ62472.1\| a... gi\|116191054, gi... - gi\|75828865\|ref\|ZP_00758198.1\| COG0010: Arginase/agmatinase/formimionoglutamate hydrolase, arginase ... gi\|15601569, gi\|... - gi\|9658241\|gb\|AAF96712.1\| agmatinase [Vibrio cholerae O1 biovar eltor str. N16961], gi\|15601569\|ref\|... gi\|11354393 - pir\|\|D82414 agmatinase VCA0814 [imported] - Vibrio cholerae (strain N16961 serogroup O1)	353.0	[0..1]	[306..1]
gi\|28808307, gi\|... - gi\|28900024\|ref\|NP_799679.1\| agmatinase [Vibrio parahaemolyticus RIMD 2210633], gi\|28808307\|dbj\|BAC6... gi\|28808307 - gi\|28808307\|dbj\|BAC61512.1\| agmatinase [Vibrio parahaemolyticus RIMD 2210633]	352.0	[0..1]	[304..1]
gi\|86147539, gi\|... - gi\|86147539\|ref\|ZP_01065850.1\| agmatinase [Vibrio sp. MED222], gi\|85834707\|gb\|EAQ52854.1\| agmatinase...	352.0	[0..1]	[304..1]
gi\|91228097, gi\|... - gi\|91228097\|ref\|ZP_01262139.1\| agmatinase [Vibrio alginolyticus 12G01], gi\|91188215\|gb\|EAS74515.1\| a...	351.0	[0..1]	[304..1]
gi\|84376170, gi\|... - gi\|84393204\|ref\|ZP_00991967.1\| agmatinase [Vibrio splendidus 12B01], gi\|84376170\|gb\|EAP93055.1\| agma...	349.0	[0..1]	[304..1]
gi\|37680171, gi\|... - gi\|37680171\|ref\|NP_934780.1\| agmatinase [Vibrio vulnificus YJ016], gi\|37198917\|dbj\|BAC94751.1\| agmat... gi\|27365674, gi\|... - gi\|27365674\|ref\|NP_761202.1\| agmatinase [Vibrio vulnificus CMCP6], gi\|27361822\|gb\|AAO10729.1\|AE01680...	348.0	[0..1]	[304..1]
gi\|59482270, gi\|... - gi\|59714022\|ref\|YP_206797.1\| agmatinase [Vibrio fischeri ES114], gi\|59482270\|gb\|AAW87909.1\| agmatina... gi\|197314033, gi... - gi\|197336781\|ref\|YP_002158518.1\| agmatinase [Vibrio fischeri MJ11], gi\|197314033\|gb\|ACH63482.1\| agma...	342.0	[0..1]	[304..1]
gi\|89075861, gi\|... - gi\|89075861\|ref\|ZP_01162240.1\| agmatinase [Photobacterium sp. SKA34], gi\|89048390\|gb\|EAR53967.1\| agm...	341.0	[0..1]	[306..1]
SPEB_PHOLL - Agmatinase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) GN=sp... SPEB_PHOLL - Agmatinase OS=Photorhabdus luminescens subsp. laumondii GN=speB PE=3 SV=1	341.0	[0..1]	[305..3]
gi\|11266243 - pir\|\|B81196 agmatinase (EC 3.5.3.11) NMA2016 [imported] - Neisseria meningitidis (strain MC58 serogr... SPEB_NEIMA - Agmatinase OS=Neisseria meningitidis serogroup A / serotype 4A (strain Z2491) GN=speB PE=3 SV=1 SPEB_NEIMB - Agmatinase OS=Neisseria meningitidis serogroup B (strain MC58) GN=speB PE=3 SV=1 SPEB_NEIMA - Agmatinase OS=Neisseria meningitidis serogroup A GN=speB PE=3 SV=1 SPEB_NEIMB - Agmatinase OS=Neisseria meningitidis serogroup B GN=speB PE=3 SV=1 gi\|254672567 - gi\|254672567\|emb\|CBA06209.1\| agmatinase [Neisseria meningitidis serogroup W135]	339.0	[0..2]	[304..4]

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Predicted Domain #1

Region A:
Residues: [1-306]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLGHQYDN SLVSNAFGFL RLPMNFQPYD SDADWVITGV PFDMATSGRA GGRHGPAAIR  60
   61 QVSTNLAWEH NRFPWNFDMR ERLNVVDCGD LVYAFGDARE MSEKLQAHAE KLLAAGKRML 120
  121 SFGGDHFVTL PLLRAHAKHF GKMALVHFDA HTDTYANGCE FDHGTMFYTA PKEGLIDPNH 180
  181 SVQIGIRTEF DKDNGFTVLD ACQVNDRSVD DVIAQVKQIV GDMPVYLTFD IDCLDPAFAP 240
  241 GTGTPVIGGL TSDRAIKLVR GLKDLNIVGM DVVEVAPAYD QSEITALAAA TLALEMLYIQ 300
  301 AAKKGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.69897
Match:	1gq6A
Description:	Proclavaminate amidino hydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
arginase activity	6.00681443593951	bayes_pls_golite062009
agmatinase activity	3.73238467801147	bayes_pls_golite062009
hydrolase activity	2.11707868768295	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.72243397396987	bayes_pls_golite062009
catalytic activity	1.68836803454021	bayes_pls_golite062009
protein deacetylase activity	1.29904902150637	bayes_pls_golite062009
histone deacetylase activity	1.25334418126662	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1.01223037319069	bayes_pls_golite062009
deacetylase activity	0.616633535035513	bayes_pls_golite062009
transcription factor binding	0.48632720319646	bayes_pls_golite062009
transcription regulator activity	0.359136428158927	bayes_pls_golite062009
transcription repressor activity	0.13614857264874	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	0.0917282383800223	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: