YRC Public Data Repository - Protein Structure Prediction

Protein:	RHAA_ECOLI
Organism:	Escherichia coli
Length:	419 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RHAA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|194438300, gi... - gi\|83586252\|ref\|ZP_00924888.1\| COG4806: L-rhamnose isomerase [Escherichia coli 101-1], gi\|194438300\|... gi\|253326502, gi... - gi\|253775458\|ref\|YP_003038289.1\| L-rhamnose isomerase [Escherichia coli BL21(DE3)], gi\|253326502\|gb\|...	509.0	[0..1]	[419..1]
RHAA_SHISS - L-rhamnose isomerase OS=Shigella sonnei (strain Ss046) GN=rhaA PE=3 SV=1	509.0	[0..1]	[419..1]
RHAA_SALCH - L-rhamnose isomerase OS=Salmonella choleraesuis GN=rhaA PE=3 SV=1 RHAA_SALPB - L-rhamnose isomerase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=rhaA PE=3 SV=1 RHAA_SALCH - L-rhamnose isomerase OS=Salmonella choleraesuis GN=rhaA PE=3 SV=1 RHAA_SALPC - L-rhamnose isomerase OS=Salmonella paratyphi C (strain RKS4594) GN=rhaA PE=3 SV=1 RHAA_SALSV - L-rhamnose isomerase OS=Salmonella schwarzengrund (strain CVM19633) GN=rhaA PE=3 SV=1 gi\|194470627, gi... - gi\|194470627\|ref\|ZP_03076611.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Ke... RHAA_SALHS - L-rhamnose isomerase OS=Salmonella heidelberg (strain SL476) GN=rhaA PE=3 SV=1 gi\|168244207, gi... - gi\|205336859\|gb\|EDZ23623.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Heidel... gi\|197289405, gi... - gi\|197289405\|gb\|EDY28770.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Schwar... gi\|205332757, gi... - gi\|205332757\|gb\|EDZ19521.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Kentuc... RHAA_SALPB - L-rhamnose isomerase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=rhaA PE=3 SV=1 RHAA_SALCH - L-rhamnose isomerase OS=Salmonella choleraesuis (strain SC-B67) GN=rhaA PE=3 SV=1	508.0	[0..1]	[418..1]
RHAA_SALPA - L-rhamnose isomerase OS=Salmonella paratyphi A GN=rhaA PE=3 SV=1 RHAA_SALPA - L-rhamnose isomerase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=rhaA PE=3 SV=1 RHAA_SALPK - L-rhamnose isomerase OS=Salmonella paratyphi A (strain AKU_12601) GN=rhaA PE=3 SV=1 gi\|205341829, gi... - gi\|205341829\|gb\|EDZ28593.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Weltev...	508.0	[0..1]	[418..1]
gi\|214001118 - gi\|214001118\|ref\|ZP_03411853.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Ty... gi\|213612465 - gi\|213612465\|ref\|ZP_03370291.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Ty... gi\|16762387 - gi\|16762387\|ref\|NP_458004.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Typhi... gi\|213581567 - gi\|213581567\|ref\|ZP_03363393.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Ty... gi\|213426093 - gi\|213426093\|ref\|ZP_03358843.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Ty... RHAA_SALTI - L-rhamnose isomerase OS=Salmonella typhi GN=rhaA PE=3 SV=1 gi\|213160856 - gi\|213160856\|ref\|ZP_03346566.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Ty... gi\|29139511, gi\|... - gi\|29143875\|ref\|NP_807217.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Typhi... RHAA_SALTI - L-rhamnose isomerase OS=Salmonella typhi GN=rhaA PE=3 SV=1	507.0	[0..1]	[418..1]
gi\|194433199, gi... - gi\|83569830\|ref\|ZP_00921279.1\| COG4806: L-rhamnose isomerase [Shigella dysenteriae 1012], gi\|1944331...	506.0	[0..1]	[419..1]
RHAA_SHIBS - L-rhamnose isomerase OS=Shigella boydii serotype 4 (strain Sb227) GN=rhaA PE=3 SV=1	506.0	[0..1]	[419..1]
gi\|197261640, gi... - gi\|197261640\|ref\|ZP_03161714.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Sa... RHAA_SALTY - L-rhamnose isomerase OS=Salmonella typhimurium GN=rhaA PE=3 SV=2 gi\|168263060, gi... - gi\|205348307\|gb\|EDZ34938.1\| L-rhamnose isomerase [Salmonella enterica subsp. enterica serovar Hadar ... RHAA_SALTY - L-rhamnose isomerase OS=Salmonella typhimurium GN=rhaA PE=3 SV=2 RHAA_SALTY - L-rhamnose isomerase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=rhaA PE=3 SV...	506.0	[0..1]	[418..1]
RHAA_SHIF8 - L-rhamnose isomerase OS=Shigella flexneri serotype 5b (strain 8401) GN=rhaA PE=3 SV=1	506.0	[0..1]	[419..1]
gi\|193068092, gi... - gi\|75238347\|ref\|ZP_00722346.1\| COG4806: L-rhamnose isomerase [Escherichia coli E110019], gi\|19306809...	505.0	[0..1]	[419..1]

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Predicted Domain #1

Region A:
Residues: [1-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTQLEQAWE LAKQRFAAVG IDVEEALRQL DRLPVSMHCW QGDDVSGFEN PEGSLTGGIQ  60
   61 ATGNYPGKAR NASELRADLE QAMRLIPGPK RLNLHAIYLE SDTPVSRDQI KPEHFKNWVE 120
  121 WAKANQLGLD FNPSCFSHPL SADGFTLSHA DDSIRQFWID HCKASRRVSA YFGEQLGTPS 180
  181 VMNIWIPDGM KDITVDRLAP RQRLLAALDE VISEKLNPAH HIDAVESKLF GIGAESYTVG 240
  241 SNEFYMGYAT SRQTALCLDA GHFHPTEVIS DKISAAMLYV PQLLLHVSRP VRWDSDHVVL 300
  301 LDDETQAIAS EIVRHDLFDR VHIGLDFFDA SINRIAAWVI GTRNMKKALL RALLEPTAEL 360
  361 RKLEAAGDYT ARLALLEEQK SLPWQAVWEM YCQRHDTPAG SEWLESVRAY EKEILSRRG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	143.0
Match:	1d8wA
Description:	L-rhamnose isomerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
L-rhamnose isomerase activity	2.97742753653623	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	2.11238407518359	bayes_pls_golite062009
catalytic activity	1.66019571685402	bayes_pls_golite062009
intramolecular oxidoreductase activity	1.64435640749982	bayes_pls_golite062009
xylose isomerase activity	1.22142207909888	bayes_pls_golite062009
nuclease activity	0.545216999092421	bayes_pls_golite062009
isomerase activity	0.52890695130173	bayes_pls_golite062009
hydrolase activity	0.256751668918719	bayes_pls_golite062009
endonuclease activity	0.0786880297920596	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: