YRC Public Data Repository - Protein Structure Prediction

Protein:	PTH_ECOLI
Organism:	Escherichia coli
Length:	194 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTH_ECOLI.

Description	E-value	Query Range	Subject Range
PTH_SHIBS - Peptidyl-tRNA hydrolase OS=Shigella boydii serotype 4 (strain Sb227) GN=pth PE=3 SV=1	294.0	[0..1]	[194..1]
PTH_PHOLL - Peptidyl-tRNA hydrolase OS=Photorhabdus luminescens subsp. laumondii GN=pth PE=3 SV=1 PTH_PHOLL - Peptidyl-tRNA hydrolase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 ...	284.0	[0..3]	[193..4]
gi\|89073086, gi\|... - gi\|89073086\|ref\|ZP_01159625.1\| peptidyl-tRNA hydrolase [Photobacterium sp. SKA34], gi\|89051039\|gb\|EA...	283.0	[0..3]	[194..5]
PTH_PSEA6 - Peptidyl-tRNA hydrolase OS=Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) GN=pth PE=3 SV=1	276.0	[0..3]	[194..4]
PTH_ACISJ - Peptidyl-tRNA hydrolase OS=Acidovorax sp. (strain JS42) GN=pth PE=3 SV=1	275.0	[0..3]	[193..2]
PTH_THICR - Peptidyl-tRNA hydrolase OS=Thiomicrospira crunogena (strain XCL-2) GN=pth PE=3 SV=1	274.0	[0..2]	[191..3]
PTH_SHIDS - Peptidyl-tRNA hydrolase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=pth PE=3 SV=1	274.0	[0..1]	[194..1]
PTH_SYNJA - Peptidyl-tRNA hydrolase OS=Synechococcus sp. (strain JA-3-3Ab) GN=pth PE=3 SV=1 gi\|86605936 - gi\|86605936\|ref\|YP_474699.1\| peptidyl-tRNA hydrolase [Cyanobacteria bacterium Yellowstone A-Prime]	273.0	[0..1]	[189..12]
gi\|197242880, gi... - gi\|197264625\|ref\|ZP_03164699.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar... gi\|200391080, gi... - gi\|200391080\|ref\|ZP_03217691.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar... PTH_SALTY - Peptidyl-tRNA hydrolase OS=Salmonella typhimurium GN=pth PE=3 SV=1 gi\|204323012, gi... - gi\|204927670\|ref\|ZP_03218871.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar... PTH_SALG2 - Peptidyl-tRNA hydrolase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=pth PE=3 SV=1 PTH_SALTY - Peptidyl-tRNA hydrolase OS=Salmonella typhimurium GN=pth PE=3 SV=1 PTH_SALNS - Peptidyl-tRNA hydrolase OS=Salmonella newport (strain SL254) GN=pth PE=3 SV=1 PTH_SALTI - Peptidyl-tRNA hydrolase OS=Salmonella typhi GN=pth PE=3 SV=1 gi\|194472071, gi... - gi\|194472071\|ref\|ZP_03078055.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar... PTH_SALSV - Peptidyl-tRNA hydrolase OS=Salmonella schwarzengrund (strain CVM19633) GN=pth PE=3 SV=1 PTH_SALA4 - Peptidyl-tRNA hydrolase OS=Salmonella agona (strain SL483) GN=pth PE=3 SV=1 gi\|168237841, gi... - gi\|197289227\|gb\|EDY28594.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar Sch... gi\|205350578, gi... - gi\|205350578\|gb\|EDZ37209.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar Had... gi\|195634529, gi... - gi\|195634529\|gb\|EDX52881.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar New... lcl\|NC_016856.1_... - [gene=pth] [protein=peptidyl-tRNA hydrolase] [protein_id=YP_005237715.1] [location=1891806..1892390] gi\|205342740, gi... - gi\|205342740\|gb\|EDZ29504.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar Wel... gi\|205321993, gi... - gi\|205321993\|gb\|EDZ09832.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar Sai... gi\|205328643, gi... - gi\|205328643\|gb\|EDZ15407.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar 4,[... gi\|205332138, gi... - gi\|205332138\|gb\|EDZ18902.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar Ken... PTH_SALTY - Peptidyl-tRNA hydrolase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=pth PE=3 ... PTH_SALTI - Peptidyl-tRNA hydrolase OS=Salmonella typhi GN=pth PE=3 SV=1 gi\|213426488 - gi\|213426488\|ref\|ZP_03359238.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar... gi\|213650575 - gi\|213650575\|ref\|ZP_03380628.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar... PTH_SALPA - Peptidyl-tRNA hydrolase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=pth PE=3 SV=2 PTH_SALEP - Peptidyl-tRNA hydrolase OS=Salmonella enteritidis PT4 (strain P125109) GN=pth PE=3 SV=1 gi\|213027308 - gi\|213027308\|ref\|ZP_03341755.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar... gi\|213163410 - gi\|213163410\|ref\|ZP_03349120.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar... gi\|213419000 - gi\|213419000\|ref\|ZP_03352066.1\| peptidyl-tRNA hydrolase [Salmonella enterica subsp. enterica serovar... PTH_SALPA - Peptidyl-tRNA hydrolase OS=Salmonella paratyphi A GN=pth PE=3 SV=2	273.0	[0..1]	[194..1]
gi\|24112603, gi\|... - gi\|24112603\|ref\|NP_707113.1\| peptidyl-tRNA hydrolase [Shigella flexneri 2a str. 301], gi\|24051507\|gb... gi\|30062728, gi\|... - gi\|30062728\|ref\|NP_836899.1\| peptidyl-tRNA hydrolase [Shigella flexneri 2a str. 2457T], gi\|30040976\|... PTH_SHIFL - Peptidyl-tRNA hydrolase OS=Shigella flexneri GN=pth PE=3 SV=1	272.0	[0..1]	[194..1]

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Predicted Domain #1

Region A:
Residues: [1-194]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIKLIVGLA NPGAEYAATR HNAGAWFVDL LAERLRAPLR EEAKFFGYTS RVTLGGEDVR  60
   61 LLVPTTFMNL SGKAVAAMAS FFRINPDEIL VAHDELDLPP GVAKFKLGGG HGGHNGLKDI 120
  121 ISKLGNNPNF HRLRIGIGHP GDKNKVVGFV LGKPPVSEQK LIDEAIDEAA RCTEMWFTDG 180
  181 LTKATNRLHA FKAQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.69897
Match:	2pthA
Description:	PEPTIDYL-TRNA HYDROLASE FROM ESCHERICHIA COLI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aminoacyl-tRNA hydrolase activity	2.52131013443946	bayes_pls_golite062009
catalytic activity	1.78077210975677	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.734671141446533	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: