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View Structure Prediction Details

Protein: dab-1
Organism: Caenorhabditis elegans
Length: 492 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dab-1.

Description E-value Query
Range
Subject
Range
dab-1 - disabled-like protein status:Confirmed UniProt:Q8I4H0 protein_id:CAB54270.3
309.0 [0..1] [492..1]
gi|187038857, gi... - gi|39587234|emb|CAE57702.1| Hypothetical protein CBG00708 [Caenorhabditis briggsae], gi|187038857|em...
gi|157749763 - gi|157749763|ref|XP_001678595.1| Hypothetical protein CBG00708 [Caenorhabditis briggsae AF16]
269.0 [0..20] [492..86]
gi|116283965 - gi|116283965|gb|AAH50108.1| Numb protein [Mus musculus]
260.0 [0..23] [311..1]
gi|28193240, gi|... - gi|28193240|emb|CAD62362.1| unnamed protein product [Homo sapiens], gi|119601513|gb|EAW81107.1| numb...
252.0 [0..23] [485..1]
gi|73956392 - gi|73956392|ref|XP_852920.1| PREDICTED: similar to Disabled homolog 1 [Canis familiaris]
252.0 [0..35] [479..113]

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Predicted Domain #1
Region A:
Residues: [1-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQKSDISVE TANATSGKPN PPSPKSRLAM LKRTKKASNA SSDPFRFQNN GISYKGKLIG  60
   61 EQDVDKARGD AMCAEAMRTA KSIIKAAGAH KTRITLQINI DGIKVLDEKS GAVLHNFPVS 120
  121 RISFIARDSS DARAFGLVYG EPGGKYKFYG IKTAQAADQA VLAIRDMFQV VFEMKKKQIE 180
  181 QVKQQQIQDG GAEISFQSKK EGGVAVADLL DLESELQQIE RGVQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.39794
Match: 1oqnA
Description: Crystal structure of the phosphotyrosine binding domain (PTB) of mouse Disabled 1 (Dab1)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [226-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSTVPTNCDA FGASPFGDPF VDSFNSTATS NGTANMSGTQ VPFGGLQLPQ VQQMQMPMVQ  60
   61 IPQQSHQNWP TSGAGSFDAW GQQQQQQQMH HAHSTPAFGT NGFSDTNPFA SAFNTQARPP 120
  121 PLPTVAPTQY RDPFSVH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [363-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSAIPNSNID WTGTGTTKEN MAPSTNIQQQ QSSLHHASTF ANFGDNKAET WSEKKVTSLE  60
   61 EAFTKLVDMD ALVGGQGIKE TKKNPFEHIL NPPKASLNSM STTCSAAQMA ATQQHTTSSH 120
  121 ADPFGDDFFR 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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