YRC Public Data Repository - Protein Structure Prediction

Protein:	PHOR_ECOLI
Organism:	Escherichia coli
Length:	431 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHOR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|192927182, gi... - gi\|75256772\|ref\|ZP_00728377.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E22],... gi\|75209956, gi\|... - gi\|75209956\|ref\|ZP_00710145.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B171]... gi\|75194619, gi\|... - gi\|75194619\|ref\|ZP_00704689.1\| COG0642: Signal transduction histidine kinase [Escherichia coli HS], ... gi\|209910870, gi... - gi\|209917611\|ref\|YP_002291695.1\| phosphate regulon sensor protein [Escherichia coli SE11], gi\|209910... gi\|157079009, gi... - gi\|75189467\|ref\|ZP_00702734.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E2437... gi\|218552962, gi... - gi\|218552962\|ref\|YP_002385875.1\| phosphate regulon sensor protein [Escherichia coli IAI1], gi\|218359...	307.0	[0..1]	[431..1]
gi\|253774615, gi... - gi\|254287270\|ref\|YP_003053018.1\| sensory histidine kinase in two-component regulatory system with Ph... gi\|242376178, gi... - gi\|251783905\|ref\|YP_002998209.1\| hypothetical protein B21_00352 [Escherichia coli BL21], gi\|24237617... gi\|83585681, gi\|... - gi\|83585681\|ref\|ZP_00924323.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 101-1... gi\|253972368, gi... - gi\|254160467\|ref\|YP_003043575.1\| sensory histidine kinase in two-component regulatory system with Ph...	307.0	[0..1]	[431..1]
gi\|197243078, gi... - gi\|197264823\|ref\|ZP_03164897.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. en... gi\|224582235, gi... - gi\|224582235\|ref\|YP_002636033.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. e... lcl\|NC_016856.1_... - [gene=phoR] [protein=phosphate regulon sensor protein] [protein_id=YP_005236087.1] [location=452247.... gi\|194406707, gi... - gi\|194448403\|ref\|YP_002044431.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteri... gi\|194470414, gi... - gi\|194470414\|ref\|ZP_03076398.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. en... gi\|195631736, gi... - gi\|195631736\|gb\|EDX50256.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|194442327, gi... - gi\|194442327\|ref\|YP_002039638.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. e... gi\|16418902, gi\|... - gi\|16763778\|ref\|NP_459393.1\| phosphate regulon sensor protein [Salmonella typhimurium LT2], gi\|16418... gi\|205333420, gi... - gi\|205333420\|gb\|EDZ20184.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|168240216, gi... - gi\|205340126\|gb\|EDZ26890.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|167551796, gi... - gi\|205323434\|gb\|EDZ11273.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|205329541, gi... - gi\|205329541\|gb\|EDZ16305.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|62126642, gi\|... - gi\|62179009\|ref\|YP_215426.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enterica s... gi\|238911468 - gi\|238911468\|ref\|ZP_04655305.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteric...	301.0	[0..1]	[431..1]
gi\|56414447, gi\|... - gi\|56414447\|ref\|YP_151522.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enterica s... gi\|197094845, gi... - gi\|197363368\|ref\|YP_002143005.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteri...	300.0	[0..1]	[431..1]
gi\|214002284 - gi\|214002284\|ref\|ZP_03413019.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteric... gi\|213427747 - gi\|213427747\|ref\|ZP_03360497.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteric... gi\|16759375 - gi\|16759375\|ref\|NP_454992.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enterica s... gi\|16501666, gi\|... - gi\|25298521\|pir\|\|AE0551 phosphate regulon sensor protein PhoR [imported] - Salmonella enterica subsp... gi\|213051514 - gi\|213051514\|ref\|ZP_03344392.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteric... gi\|29138486, gi\|... - gi\|29142854\|ref\|NP_806196.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enterica s... gi\|213027063 - gi\|213027063\|ref\|ZP_03341510.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteric...	299.0	[0..1]	[431..1]
gi\|81244300, gi\|... - gi\|82542889\|ref\|YP_406836.1\| phosphate regulon sensor protein [Shigella boydii Sb227], gi\|81244300\|g... gi\|24050565, gi\|... - gi\|24111778\|ref\|NP_706288.1\| phosphate regulon sensor protein [Shigella flexneri 2a str. 301], gi\|24... gi\|30040140, gi\|... - gi\|30061896\|ref\|NP_836067.1\| phosphate regulon sensor protein [Shigella flexneri 2a str. 2457T], gi\|... gi\|110613971, gi... - gi\|110804423\|ref\|YP_687943.1\| phosphate regulon sensor protein [Shigella flexneri 5 str. 8401], gi\|1...	298.0	[0..1]	[431..1]
gi\|188493157, gi... - gi\|75512461\|ref\|ZP_00735000.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 53638...	298.0	[0..1]	[431..1]
gi\|218688262, gi... - gi\|218688262\|ref\|YP_002396474.1\| phosphate regulon sensor protein [Escherichia coli ED1a], gi\|218425... gi\|218557309, gi... - gi\|218557309\|ref\|YP_002390222.1\| phosphate regulon sensor protein [Escherichia coli S88], gi\|2183640... gi\|227884594, gi... - gi\|227884594\|ref\|ZP_04002399.1\| PAS/PAC sensor signal transduction histidine kinase [Escherichia col... gi\|218368682, gi... - gi\|218698696\|ref\|YP_002406325.1\| phosphate regulon sensor protein [Escherichia coli IAI39], gi\|21836... gi\|237707607, gi... - gi\|237707607\|ref\|ZP_04538088.1\| phosphate regulon sensor protein phoR [Escherichia sp. 3_2_53FAA], g... gi\|218350592, gi... - gi\|218693860\|ref\|YP_002401527.1\| phosphate regulon sensor protein [Escherichia coli 55989], gi\|21835... gi\|26246404, gi\|... - gi\|26246404\|ref\|NP_752443.1\| phosphate regulon sensor protein [Escherichia coli CFT073], gi\|26106802... gi\|194419136, gi... - gi\|83570332\|ref\|ZP_00921777.1\| COG0642: Signal transduction histidine kinase [Shigella dysenteriae 1... gi\|75230125, gi\|... - gi\|75230125\|ref\|ZP_00716629.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B7A],... gi\|75237219, gi\|... - gi\|75237219\|ref\|ZP_00721266.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E1100...	297.0	[0..1]	[431..1]
gi\|13359907, gi\|... - gi\|15829704\|ref\|NP_308477.1\| phosphate regulon sensor protein [Escherichia coli O157:H7 str. Sakai],... gi\|13359907, gi\|... - gi\|15829704\|ref\|NP_308477.1\| PhoR [Escherichia coli O157:H7], gi\|13359907\|dbj\|BAB33873.1\| positive a... gi\|209744228, gi... - pir\|\|F85535 hypothetical protein phoR [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|217325530, gi... - gi\|217325530\|ref\|ZP_03441614.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str.... gi\|15800126, gi\|... - gi\|15800126\|ref\|NP_286138.1\| phosphate regulon sensor protein [Escherichia coli O157:H7 EDL933], gi\|... gi\|195938539 - gi\|195938539\|ref\|ZP_03083921.1\| phosphate regulon sensor protein [Escherichia coli O157:H7 str. EC40... gi\|189377386, gi... - gi\|189377386\|gb\|EDU95802.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC5... gi\|168786238, gi... - gi\|189373469\|gb\|EDU91885.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC8... gi\|168783257, gi... - gi\|188999394\|gb\|EDU68380.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|209159660, gi... - gi\|209398260\|ref\|YP_002269038.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str... gi\|208737438, gi... - gi\|208823245\|ref\|ZP_03263563.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str.... gi\|208815881, gi... - gi\|208815881\|ref\|ZP_03257060.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str.... gi\|208727269, gi... - gi\|208807468\|ref\|ZP_03249805.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str.... gi\|168749853, gi... - gi\|188015838\|gb\|EDU53960.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|168776303, gi... - gi\|187768310\|gb\|EDU32154.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|189362390, gi... - gi\|189362390\|gb\|EDU80809.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|168761597, gi... - gi\|189368101\|gb\|EDU86517.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|168756933, gi... - gi\|189356011\|gb\|EDU74430.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|254791578, gi... - gi\|254791578\|ref\|YP_003076415.1\| sensory histidine kinase in two-component regulatory system with Ph...	297.0	[0..1]	[431..1]
gi\|75238727, gi\|... - gi\|75238727\|ref\|ZP_00722715.1\| COG0642: Signal transduction histidine kinase [Escherichia coli F11],... gi\|110640661, gi... - gi\|110640661\|ref\|YP_668389.1\| phosphate regulon sensor protein [Escherichia coli 536], gi\|110342253\|...	297.0	[0..1]	[431..1]

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Predicted Domain #1

Region A:
Residues: [1-70]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLERLSWKRL VLELLLCCLP AFILGAFFGY LPWFLLASVT GLLIWHFWNL LRLSWWLWVD  60
   61 RSMTPPPGRG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.861	a.77.1	DEATH domain

Predicted Domain #2

Region A:
Residues: [71-183]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SWEPLLYGLH QMQLRNKKRR RELGNLIKRF RSGAESLPDA VVLTTEEGGI FWCNGLAQQI  60
   61 LGLRWPEDNG QNILNLLRYP EFTQYLKTRD FSRPLNLVLN TGRHLEIRVM PYT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.0
Match:	1d06A
Description:	Histidine kinase FixL heme domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [184-431]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKQLLMVARD VTQMHQLEGA RRNFFANVSH ELRTPLTVLQ GYLEMMNEQP LEGAVREKAL  60
   61 HTMREQTQRM EGLVKQLLTL SKIEAAPTHL LNEKVDVPMM LRVVEREAQT LSQKKQTFTF 120
  121 EIDNGLKVSG NEDQLRSAIS NLVYNAVNHT PEGTHITVRW QRVPHGAEFS VEDNGPGIAP 180
  181 EHIPRLTERF YRVDKARSRQ TGGSGLGLAI VKHAVNHHES RLNIESTVGK GTRFSFVIPE 240
  241 RLIAKNSD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.522879
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits