YRC Public Data Repository - Protein Structure Prediction

Protein:	NUDC_ECOLI
Organism:	Escherichia coli
Length:	257 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NUDC_ECOLI.

Description	E-value	Query Range	Subject Range
NUDC_ECOK1 - NADH pyrophosphatase OS=Escherichia coli O1:K1 / APEC GN=nudC PE=3 SV=1 NUDC_ECO45 - NADH pyrophosphatase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=nudC PE=3 SV=1 NUDC_ECOUT - NADH pyrophosphatase OS=Escherichia coli (strain UTI89 / UPEC) GN=nudC PE=3 SV=1 gi\|237702763, gi... - gi\|237702763\|ref\|ZP_04533244.1\| NADH pyrophosphatase NudC [Escherichia sp. 3_2_53FAA], gi\|226903076\|...	248.0	[0..1]	[257..1]
NUDC_ECO27 - NADH pyrophosphatase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=nudC PE=3 SV=1 sp\|B7UPF1\|NUDC_ECO27 - NADH pyrophosphatase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=nudC PE=3 SV=1 NUDC_ECOL6 - NADH pyrophosphatase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=nudC PE=3 SV=... NUDC_ECOL5 - NADH pyrophosphatase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=nudC PE=3 SV=1 NUDC_ECO81 - NADH pyrophosphatase OS=Escherichia coli O81 (strain ED1a) GN=nudC PE=3 SV=1 gi\|227837548, gi... - gi\|227885474\|ref\|ZP_04003279.1\| NADH pyrophosphatase [Escherichia coli 83972], gi\|227837548\|gb\|EEJ48... gi\|75236726, gi\|... - gi\|75236726\|ref\|ZP_00720799.1\| COG2816: NTP pyrophosphohydrolases containing a Zn-finger, probably n... NUDC_ECOL6 - NADH pyrophosphatase OS=Escherichia coli O6 GN=nudC PE=3 SV=1	248.0	[0..1]	[257..1]
NUDC_SHIB3 - NADH pyrophosphatase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=nudC PE=3 SV=1 NUDC_SHIBS - NADH pyrophosphatase OS=Shigella boydii serotype 4 (strain Sb227) GN=nudC PE=3 SV=1	246.0	[0..1]	[257..1]
NUDC_ECOLU - NADH pyrophosphatase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=nudC PE=3 SV=1 NUDC_SHIF8 - NADH pyrophosphatase OS=Shigella flexneri serotype 5b (strain 8401) GN=nudC PE=3 SV=1	246.0	[0..1]	[257..1]
gi\|194434772, gi... - gi\|83569014\|ref\|ZP_00920477.1\| COG2816: NTP pyrophosphohydrolases containing a Zn-finger, probably n...	246.0	[0..1]	[257..1]
gi\|208726052, gi... - gi\|208806251\|ref\|ZP_03248588.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4206], gi\|2087... gi\|208814365, gi... - gi\|208814365\|ref\|ZP_03255694.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4045], gi\|2087... gi\|208739833, gi... - gi\|208819710\|ref\|ZP_03260030.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4042], gi\|2087... NUDC_ECO5E - NADH pyrophosphatase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=nudC PE=3 SV=1 gi\|168780380, gi... - gi\|189001808\|gb\|EDU70794.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4076], gi\|16878038... gi\|189370174, gi... - gi\|189370174\|gb\|EDU88590.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC869], gi\|168790355... gi\|189379054, gi... - gi\|189379054\|gb\|EDU97470.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC508], gi\|168798371... gi\|195939622 - gi\|195939622\|ref\|ZP_03085004.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4024] gi\|168758609, gi... - gi\|189354595\|gb\|EDU73014.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4401], gi\|16875860... gi\|189365468, gi... - gi\|189365468\|gb\|EDU83884.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4501], gi\|16876457... gi\|189359754, gi... - gi\|189359754\|gb\|EDU78173.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4486], gi\|16877146... gi\|187767361, gi... - gi\|187767361\|gb\|EDU31205.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4196], gi\|16877739... NUDC_ECO57 - NADH pyrophosphatase OS=Escherichia coli O157:H7 GN=nudC PE=3 SV=1 gi\|12518925, gi\|... - gi\|15804587\|ref\|NP_290628.1\| NADH pyrophosphatase [Escherichia coli O157:H7 EDL933], gi\|12518925\|gb\|... gi\|209751718, gi... - pir\|\|E86091 hypothetical protein yjaD [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|168752040, gi... - gi\|188014017\|gb\|EDU52139.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. EC4113], gi\|16875204... gi\|254595394, gi... - gi\|254795994\|ref\|YP_003080831.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. TW14359], gi\|25... gi\|15834173, gi\|... - gi\|15834173\|ref\|NP_312946.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. Sakai], gi\|13364395... gi\|217324704, gi... - gi\|217324704\|ref\|ZP_03440788.1\| NADH pyrophosphatase [Escherichia coli O157:H7 str. TW14588], gi\|217...	246.0	[0..1]	[257..1]
gi\|396335\|gb\|AAC... - ORF_o257 [Escherichia coli] gi\|396335, gi\|74... - pir\|\|G65206 NADH pyrophosphatase (EC 3.6.1.-) - Escherichia coli (strain K-12), gi\|396335\|gb\|AAC430... gi\|16131826\|ref\|... - hypothetical protein b3996 [Escherichia coli K12], hypothetical protein b3996 [Escherichia coli K12]	245.0	[0..1]	[257..1]
gi\|193066413, gi... - gi\|75255493\|ref\|ZP_00727292.1\| COG2816: NTP pyrophosphohydrolases containing a Zn-finger, probably n...	245.0	[0..1]	[257..1]
NUDC_SHIFL - NADH pyrophosphatase OS=Shigella flexneri GN=nudC PE=3 SV=1 gi\|24115280, gi\|... - gi\|24115280\|ref\|NP_709790.1\| NADH pyrophosphatase [Shigella flexneri 2a str. 301], gi\|24054574\|gb\|AA... gi\|30042982, gi\|... - gi\|30064722\|ref\|NP_838893.1\| NADH pyrophosphatase [Shigella flexneri 2a str. 2457T], gi\|30042982\|gb\|...	244.0	[0..1]	[257..1]
gi\|84393080, gi\|... - gi\|84393080\|ref\|ZP_00991846.1\| NADH pyrophosphatase [Vibrio splendidus 12B01], gi\|84376332\|gb\|EAP932...	244.0	[0..4]	[246..1]

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Predicted Domain #1

Region A:
Residues: [1-257]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRIIEKLDH GWWVVSHEQK LWLPKGELPY GEAANFDLVG QRALQIGEWQ GEPVWLVQQQ  60
   61 RRHDMGSVRQ VIDLDVGLFQ LAGRGVQLAE FYRSHKYCGY CGHEMYPSKT EWAMLCSHCR 120
  121 ERYYPQIAPC IIVAIRRDDS ILLAQHTRHR NGVHTVLAGF VEVGETLEQA VAREVMEESG 180
  181 IKVKNLRYVT SQPWPFPQSL MTAFMAEYDS GDIVIDPKEL LEANWYRYDD LPLLPPPGTV 240
  241 ARRLIEDTVA MCRAEYE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.221849
Match:	1vk6A
Description:	Crystal structure of NADH pyrophosphatase (1790429) from Escherichia coli k12 at 2.20 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.86119802438676	bayes_pls_golite062009
hydrolase activity	0.97790691270817	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.544115189438	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.54377405132398	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: