YRC Public Data Repository - Protein Structure Prediction

Protein:	MURA_ECOLI
Organism:	Escherichia coli
Length:	419 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MURA_ECOLI.

Description	E-value	Query Range	Subject Range
MURA_ENTCL - UDP-N-acetylglucosamine 1-carboxyvinyltransferase OS=Enterobacter cloacae GN=murA PE=1 SV=1 MURA_ENTCC - UDP-N-acetylglucosamine 1-carboxyvinyltransferase OS=Enterobacter cloacae subsp. cloacae (strain ATC...	518.0	[0..1]	[419..1]
MURA_ECO57 - UDP-N-acetylglucosamine 1-carboxyvinyltransferase OS=Escherichia coli O157:H7 GN=murA PE=3 SV=1 gi\|208735721, gi... - gi\|208814444\|ref\|ZP_03255773.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli ... gi\|208739375, gi... - gi\|208819252\|ref\|ZP_03259572.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli ... MURA_ECO5E - UDP-N-acetylglucosamine 1-carboxyvinyltransferase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)... gi\|217319478, gi... - gi\|217327111\|ref\|ZP_03443194.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli ... gi\|168781333, gi... - gi\|189000969\|gb\|EDU69955.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli O157... gi\|189373783, gi... - gi\|189373783\|gb\|EDU92199.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli O157... gi\|195940045 - gi\|195940045\|ref\|ZP_03085427.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli ... gi\|208728567, gi... - gi\|208808766\|ref\|ZP_03251103.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli ... gi\|188014361, gi... - gi\|188014361\|gb\|EDU52483.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli O157... gi\|168754171, gi... - gi\|189358394\|gb\|EDU76813.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli O157... gi\|189361807, gi... - gi\|189361807\|gb\|EDU80226.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli O157... gi\|15803729, gi\|... - gi\|15803729\|ref\|NP_289763.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli O15... gi\|209758150, gi... - pir\|\|G85982 UDP-N-glucosamine 1-carboxyvinyltransferase [imported] - Escherichia coli (strain O157:H... gi\|13363541, gi\|... - gi\|15833322\|ref\|NP_312095.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli O15... gi\|254594538, gi... - gi\|254795138\|ref\|YP_003079975.1\| UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli...	513.0	[0..1]	[419..1]
MURA_SHIB3 - UDP-N-acetylglucosamine 1-carboxyvinyltransferase OS=Shigella boydii serotype 18 (strain CDC 3083-94... MURA_SHIBS - UDP-N-acetylglucosamine 1-carboxyvinyltransferase OS=Shigella boydii serotype 4 (strain Sb227) GN=mu...	513.0	[0..1]	[419..1]
gi\|4972324 - gi\|4972324\|dbj\|BAA78108.1\| UDP-N-acetylglucosamine enolpyruvoyl transferase [Escherichia coli]	512.0	[0..1]	[419..1]
MURA_ERWCT - UDP-N-acetylglucosamine 1-carboxyvinyltransferase OS=Erwinia carotovora subsp. atroseptica GN=murA P... MURA_PECAS - UDP-N-acetylglucosamine 1-carboxyvinyltransferase OS=Pectobacterium atrosepticum (strain SCRI 1043 /...	511.0	[0..1]	[418..1]
MURA_SHIDS - UDP-N-acetylglucosamine 1-carboxyvinyltransferase OS=Shigella dysenteriae serotype 1 (strain Sd197) ...	511.0	[0..1]	[419..1]

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Predicted Domain #1

Region A:
Residues: [1-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKFRVQGPT KLQGEVTISG AKNAALPILF AALLAEEPVE IQNVPKLKDV DTSMKLLSQL  60
   61 GAKVERNGSV HIDARDVNVF CAPYDLVKTM RASIWALGPL VARFGQGQVS LPGGCTIGAR 120
  121 PVDLHISGLE QLGATIKLEE GYVKASVDGR LKGAHIVMDK VSVGATVTIM CAATLAEGTT 180
  181 IIENAAREPE IVDTANFLIT LGAKISGQGT DRIVIEGVER LGGGVYRVLP DRIETGTFLV 240
  241 AAAISRGKII CRNAQPDTLD AVLAKLRDAG ADIEVGEDWI SLDMHGKRPK AVNVRTAPHP 300
  301 AFPTDMQAQF TLLNLVAEGT GFITETVFEN RFMHVPELSR MGAHAEIESN TVICHGVEKL 360
  361 SGAQVMATDL RASASLVLAG CIAEGTTVVD RIYHIDRGYE RIEDKLRALG ANIERVKGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	147.0
Match:	1nawA
Description:	UDP-N-acetylglucosamine enolpyruvyl transferase (EPT, MurA, MurZ)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-phosphoshikimate 1-carboxyvinyltransferase activity	4.6363282422962	bayes_pls_golite062009
UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity	3.87711259634234	bayes_pls_golite062009
catalytic activity	2.91733519293428	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	2.15049036934665	bayes_pls_golite062009
transferase activity	1.9014276549152	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: