YRC Public Data Repository - Protein Structure Prediction

Protein:	MRAW_ECOLI
Organism:	Escherichia coli
Length:	313 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRAW_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|76177 - pir\|\|QQECFT yabC protein - Escherichia coli (strain K-12) gi\|115511492, gi... - gi\|117622368\|ref\|YP_851281.1\| S-adenosyl-methyltransferase MraW [Escherichia coli APEC O1], gi\|11551...	408.0	[0..1]	[313..34]
gi\|30039891, gi\|... - gi\|30061649\|ref\|NP_835820.1\| S-adenosyl-methyltransferase MraW [Shigella flexneri 2a str. 2457T], gi... RSMH_SHIFL - Ribosomal RNA small subunit methyltransferase H OS=Shigella flexneri GN=rsmH PE=3 SV=1 gi\|24050285, gi\|... - gi\|24111527\|ref\|NP_706037.1\| S-adenosyl-methyltransferase MraW [Shigella flexneri 2a str. 301], gi\|2...	403.0	[0..1]	[313..1]
RSMH_SHIDS - Ribosomal RNA small subunit methyltransferase H OS=Shigella dysenteriae serotype 1 (strain Sd197) GN...	403.0	[0..1]	[312..1]
RSMH_SHIF8 - Ribosomal RNA small subunit methyltransferase H OS=Shigella flexneri serotype 5b (strain 8401) GN=rs...	403.0	[0..1]	[313..1]
RSMH_SHISS - Ribosomal RNA small subunit methyltransferase H OS=Shigella sonnei (strain Ss046) GN=rsmH PE=3 SV=1	403.0	[0..1]	[313..1]
RSMH_ECOL6 - Ribosomal RNA small subunit methyltransferase H OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 7009... RSMH_ECOL6, MRAW... - Ribosomal RNA small subunit methyltransferase H OS=Escherichia coli O6 GN=rsmH PE=3 SV=1, S-adenosyl...	402.0	[0..1]	[313..1]
RSMH_SALEP - Ribosomal RNA small subunit methyltransferase H OS=Salmonella enteritidis PT4 (strain P125109) GN=rs... RSMH_SALPC - Ribosomal RNA small subunit methyltransferase H OS=Salmonella paratyphi C (strain RKS4594) GN=rsmH P... RSMH_SALA4 - Ribosomal RNA small subunit methyltransferase H OS=Salmonella agona (strain SL483) GN=rsmH PE=3 SV=1 RSMH_SALDC - Ribosomal RNA small subunit methyltransferase H OS=Salmonella dublin (strain CT_02021853) GN=rsmH PE... gi\|200386674, gi... - gi\|200386674\|ref\|ZP_03213286.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enteri... RSMH_SALG2 - Ribosomal RNA small subunit methyltransferase H OS=Salmonella gallinarum (strain 287/91 / NCTC 13346... gi\|205342387, gi... - gi\|205342387\|gb\|EDZ29151.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enterica s... MRAW_SALTY - S-adenosyl-L-methionine-dependent methyltransferase mraW OS=Salmonella typhimurium GN=mraW PE=3 SV=1 RSMH_SALHS - Ribosomal RNA small subunit methyltransferase H OS=Salmonella heidelberg (strain SL476) GN=rsmH PE=3... gi\|194469862, gi... - gi\|194469862\|ref\|ZP_03075846.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enteri... RSMH_SALSV - Ribosomal RNA small subunit methyltransferase H OS=Salmonella schwarzengrund (strain CVM19633) GN=rs... gi\|205335013, gi... - gi\|205335013\|gb\|EDZ21777.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enterica s... gi\|197292032, gi... - gi\|197292032\|gb\|EDY31382.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enterica s... gi\|205337535, gi... - gi\|205337535\|gb\|EDZ24299.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enterica s... gi\|238911177 - gi\|238911177\|ref\|ZP_04655014.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enteri... gi\|205348778, gi... - gi\|205348778\|gb\|EDZ35409.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enterica s... lcl\|NC_016856.1_... - [gene=mraW] [protein=S-adenosyl-methyltransferase MraW] [protein_id=YP_005235779.1] [location=141119... gi\|167550685, gi... - gi\|205324445\|gb\|EDZ12284.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enterica s... MRAW_SALTY, RSMH... - Ribosomal RNA small subunit methyltransferase H OS=Salmonella typhimurium GN=rsmH PE=3 SV=1, S-adeno... gi\|205331448, gi... - gi\|205331448\|gb\|EDZ18212.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enterica s... RSMH_SALTY - Ribosomal RNA small subunit methyltransferase H OS=Salmonella typhimurium (strain LT2 / SGSC1412 / A...	397.0	[0..1]	[313..1]
RSMH_SALPA, MRAW... - Ribosomal RNA small subunit methyltransferase H OS=Salmonella paratyphi A GN=rsmH PE=3 SV=1, S-adeno... RSMH_SALPK - Ribosomal RNA small subunit methyltransferase H OS=Salmonella paratyphi A (strain AKU_12601) GN=rsmH... RSMH_SALPA - Ribosomal RNA small subunit methyltransferase H OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42...	397.0	[0..1]	[313..1]
gi\|213858022 - gi\|213858022\|ref\|ZP_03384993.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enteri... gi\|213585689 - gi\|213585689\|ref\|ZP_03367515.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enteri... gi\|213426162 - gi\|213426162\|ref\|ZP_03358912.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enteri... gi\|213052857 - gi\|213052857\|ref\|ZP_03345735.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enteri... MRAW_SALTI - S-adenosyl-L-methionine-dependent methyltransferase mraW OS=Salmonella typhi GN=mraW PE=3 SV=1 gi\|29136289, gi\|... - gi\|29140665\|ref\|NP_804007.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enterica ... gi\|16759115 - gi\|16759115\|ref\|NP_454732.1\| S-adenosyl-methyltransferase MraW [Salmonella enterica subsp. enterica ... RSMH_SALTI - Ribosomal RNA small subunit methyltransferase H OS=Salmonella typhi GN=rsmH PE=3 SV=1	394.0	[0..1]	[313..1]
RSMH_SALCH - Ribosomal RNA small subunit methyltransferase H OS=Salmonella choleraesuis (strain SC-B67) GN=rsmH P... MRAW_SALCH - S-adenosyl-L-methionine-dependent methyltransferase mraW OS=Salmonella choleraesuis GN=mraW PE=3 SV=... MRAW_SALCH, RSMH... - Ribosomal RNA small subunit methyltransferase H OS=Salmonella choleraesuis GN=rsmH PE=3 SV=1, S-aden...	393.0	[0..2]	[313..1]

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Predicted Domain #1

Region A:
Residues: [1-313]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMENYKHTTV LLDEAVNGLN IRPDGIYIDG TFGRGGHSRL ILSQLGEEGR LLAIDRDPQA  60
   61 IAVAKTIDDP RFSIIHGPFS ALGEYVAERD LIGKIDGILL DLGVSSPQLD DAERGFSFMR 120
  121 DGPLDMRMDP TRGQSAAEWL QTAEEADIAW VLKTYGEERF AKRIARAIVE RNREQPMTRT 180
  181 KELAEVVAAA TPVKDKFKHP ATRTFQAVRI WVNSELEEIE QALKSSLNVL APGGRLSIIS 240
  241 FHSLEDRIVK RFMRENSRGP QVPAGLPMTE EQLKKLGGRQ LRALGKLMPG EEEVAENPRA 300
  301 RSSVLRIAER TNA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.522879
Match:	1wg8A
Description:	Crystal structure of a predicted S-adenosylmethionine-dependent methyltransferase TT1512 from Thermus thermophilus HB8.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.25333584501255	bayes_pls_golite062009
transferase activity	1.07321114919891	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.644010137949015	bayes_pls_golite062009
methyltransferase activity	0.635463629299812	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.484303056110644	bayes_pls_golite062009
rRNA methyltransferase activity	0.431436890079007	bayes_pls_golite062009
RNA methyltransferase activity	0.390180181426808	bayes_pls_golite062009
N-methyltransferase activity	0.114147051814785	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: