YRC Public Data Repository - Protein Structure Prediction

Protein:	MHPE_ECOLI
Organism:	Escherichia coli
Length:	337 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MHPE_ECOLI.

Description	E-value	Query Range	Subject Range
LEU1_AQUAE - 2-isopropylmalate synthase OS=Aquifex aeolicus GN=leuA PE=3 SV=2 LEU1_AQUAE - 2-isopropylmalate synthase OS=Aquifex aeolicus (strain VF5) GN=leuA PE=3 SV=2	332.0	[0..3]	[335..2]
LEU1_CARHZ - 2-isopropylmalate synthase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-...	332.0	[0..4]	[337..2]
gi\|46201202 - gi\|46201202\|ref\|ZP_00055539.2\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Magnetosp...	331.0	[0..1]	[335..1]
gi\|15607049, gi\|... - gi\|2984301\|gb\|AAC07824.1\| 2-isopropylmalate synthase [Aquifex aeolicus VF5], gi\|15607049\|ref\|NP_2144... gi\|7447051 - gi\|7447051\|pir\|\|B70479 2-isopropylmalate synthase (EC 4.1.3.12) - Aquifex aeolicus	331.0	[0..3]	[335..6]
LEU1_NITEC - 2-isopropylmalate synthase OS=Nitrosomonas eutropha (strain C91) GN=leuA PE=3 SV=1	331.0	[0..3]	[337..2]
gi\|91718673, gi\|... - gi\|91762871\|ref\|ZP_01264836.1\| 2-isopropylmalate synthase [Candidatus Pelagibacter ubique HTCC1002],...	330.0	[0..2]	[335..3]
LEU1_PYRFU - 2-isopropylmalate synthase OS=Pyrococcus furiosus GN=leuA PE=3 SV=1 LEU1_PYRFU - 2-isopropylmalate synthase OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN...	330.0	[0..4]	[337..3]
LEU11_SULTO, LE1... - 2-isopropylmalate synthase 1 OS=Sulfolobus tokodaii GN=leuA1 PE=3 SV=1, (Q974X3) 2-isopropylmalate s... LEU1_SULTO - Probable 2-isopropylmalate synthase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 1001...	329.0	[0..2]	[336..8]
LEU1_NITEU - 2-isopropylmalate synthase OS=Nitrosomonas europaea GN=leuA PE=3 SV=1 LEU1_NITEU - 2-isopropylmalate synthase OS=Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298) GN=leuA PE=3 SV...	329.0	[0..3]	[335..2]
gi\|82500470, gi\|... - gi\|82500470\|ref\|ZP_00885883.1\| 2-isopropylmalate synthase [Caldicellulosiruptor saccharolyticus DSM ...	328.0	[0..1]	[335..1]

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Predicted Domain #1

Region A:
Residues: [1-337]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGKKLYISD VTLRDGMHAI RHQYSLENVR QIAKALDDAR VDSIEVAHGD GLQGSSFNYG  60
   61 FGAHSDLEWI EAAADVVKHA KIATLLLPGI GTIHDLKNAW QAGARVVRVA THCTEADVSA 120
  121 QHIQYARELG MDTVGFLMMS HMTTPENLAK QAKLMEGYGA TCIYVVDSGG AMNMSDIRDR 180
  181 FRALKAELKP ETQTGMHAHH NLSLGVANSI AAVEEGCDRI DASLAGMGAG AGNAPLEVFI 240
  241 AAADKLGWQH GTDLYALMDA ADDLVRPLQD RPVRVDRETL ALGYAGVYSS FLRHCETAAA 300
  301 RYGLSAVDIL VELGKRRMVG GQEDMIVDVA LDLRNNK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.0
Match:	1nvmA
Description:	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain; 4-hydroxy-2-oxovalerate aldolase DmpG, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	3.04075198078553	bayes_pls_golite062009
carbon-carbon lyase activity	1.00678396839999	bayes_pls_golite062009
lyase activity	0.437176828950096	bayes_pls_golite062009
aldehyde-lyase activity	0.41660515357045	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: