YRC Public Data Repository - Protein Structure Prediction

Protein:	MEPA_ECOLI
Organism:	Escherichia coli
Length:	274 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MEPA_ECOLI.

Description	E-value	Query Range	Subject Range
MEPA_SALTY - Penicillin-insensitive murein endopeptidase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC ... gi\|204321765, gi... - gi\|204929221\|ref\|ZP_03220364.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica sub... MEPA_SALG2 - Penicillin-insensitive murein endopeptidase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN... MEPA_SALEP - Penicillin-insensitive murein endopeptidase OS=Salmonella enteritidis PT4 (strain P125109) GN=mepA P... MEPA_SALA4 - Penicillin-insensitive murein endopeptidase OS=Salmonella agona (strain SL483) GN=mepA PE=3 SV=1 gi\|197241281, gi... - gi\|197263026\|ref\|ZP_03163100.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica sub... MEPA_SALDC - Penicillin-insensitive murein endopeptidase OS=Salmonella dublin (strain CT_02021853) GN=mepA PE=3 S... MEPA_SALTY - Penicillin-insensitive murein endopeptidase OS=Salmonella typhimurium GN=mepA PE=3 SV=1 gi\|200388495, gi... - gi\|200388495\|ref\|ZP_03215107.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica sub... gi\|167993072, gi... - gi\|205328818\|gb\|EDZ15582.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica subsp. ... gi\|168237408, gi... - gi\|197289596\|gb\|EDY28959.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica subsp. ... MEPA_SALNS - Penicillin-insensitive murein endopeptidase OS=Salmonella newport (strain SL254) GN=mepA PE=3 SV=1 MEPA_SALSV - Penicillin-insensitive murein endopeptidase OS=Salmonella schwarzengrund (strain CVM19633) GN=mepA P... MEPA_SALTY - Penicillin-insensitive murein endopeptidase OS=Salmonella typhimurium GN=mepA PE=3 SV=1 lcl\|NC_016856.1_... - [gene=mepA] [protein=penicillin-insensitive murein endopeptidase] [protein_id=YP_005238467.1] [locat...	414.0	[0..1]	[274..1]
MEPA_SALTI - Penicillin-insensitive murein endopeptidase OS=Salmonella typhi GN=mepA PE=3 SV=1 gi\|238912338 - gi\|238912338\|ref\|ZP_04656175.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica sub... gi\|16761307 - gi\|16761307\|ref\|NP_456924.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica subsp.... gi\|213650418 - gi\|213650418\|ref\|ZP_03380471.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica sub... gi\|213854940 - gi\|213854940\|ref\|ZP_03383180.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica sub... MEPA_SALTI - Penicillin-insensitive murein endopeptidase OS=Salmonella typhi GN=mepA PE=3 SV=1 gi\|214001641 - gi\|214001641\|ref\|ZP_03412376.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica sub... gi\|29140997, gi\|... - gi\|29140997\|ref\|NP_804339.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica subsp.... gi\|205345118, gi... - gi\|205345118\|gb\|EDZ31882.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica subsp. ... MEPA_SALPK - Penicillin-insensitive murein endopeptidase OS=Salmonella paratyphi A (strain AKU_12601) GN=mepA PE=... gi\|213161568 - gi\|213161568\|ref\|ZP_03347278.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica sub... gi\|213612526 - gi\|213612526\|ref\|ZP_03370352.1\| penicillin-insensitive murein endopeptidase [Salmonella enterica sub...	414.0	[0..1]	[274..1]
gi\|15602225, gi\|... - gi\|15602225\|ref\|NP_245297.1\| penicillin-insensitive murein endopeptidase [Pasteurella multocida subs...	410.0	[0..1]	[271..1]
MEPA_SALCH - Penicillin-insensitive murein endopeptidase OS=Salmonella choleraesuis (strain SC-B67) GN=mepA PE=3 ... MEPA_SALCH - Penicillin-insensitive murein endopeptidase OS=Salmonella choleraesuis GN=mepA PE=3 SV=1 MEPA_SALCH - Penicillin-insensitive murein endopeptidase OS=Salmonella choleraesuis GN=mepA PE=3 SV=1	410.0	[0..1]	[274..1]
MEPA_SALPA - Penicillin-insensitive murein endopeptidase OS=Salmonella paratyphi A GN=mepA PE=3 SV=1 MEPA_SALPA - Penicillin-insensitive murein endopeptidase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN...	409.0	[0..1]	[274..1]
gi\|46128949 - gi\|46128949\|ref\|ZP_00154683.2\| COG3770: Murein endopeptidase [Haemophilus influenzae R2846]	405.0	[0..1]	[271..5]
gi\|145271112, gi... - gi\|145639744\|ref\|ZP_01795346.1\| penicillin-insensitive murein endopeptidase [Haemophilus influenzae ... gi\|145637361, gi... - gi\|145637361\|ref\|ZP_01793021.1\| penicillin-insensitive murein endopeptidase [Haemophilus influenzae ... gi\|144978974, gi... - gi\|145628504\|ref\|ZP_01784304.1\| penicillin-insensitive murein endopeptidase [Haemophilus influenzae ... gi\|53733133 - gi\|53733133\|ref\|ZP_00156039.2\| COG3770: Murein endopeptidase [Haemophilus influenzae R2866]	405.0	[0..1]	[271..5]
gi\|48867693, gi\|... - gi\|68248802\|ref\|YP_247914.1\| penicillin-insensitive murein endopeptidase [Haemophilus influenzae 86-...	404.0	[0..1]	[271..5]
gi\|89072649, gi\|... - gi\|89072649\|ref\|ZP_01159214.1\| penicillin-insensitive murein endopeptidase [Photobacterium sp. SKA34...	402.0	[0..1]	[271..1]
MEPA_HAEIN - Penicillin-insensitive murein endopeptidase OS=Haemophilus influenzae GN=mepA PE=3 SV=1 MEPA_HAEIN - Penicillin-insensitive murein endopeptidase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121...	402.0	[0..1]	[271..5]

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Predicted Domain #1

Region A:
Residues: [1-274]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKTAIALLA LLASSASLAA TPWQKITQPV PGSAQSIGSF SNGCIVGADT LPIQSEHYQV  60
   61 MRTDQRRYFG HPDLVMFIQR LSSQVSNLGM GTVLIGDMGM PAGGRFNGGH ASHQTGLDVD 120
  121 IFLQLPKTRW TSAQLLRPQA LDLVSRDGKH VVSTLWKPEI FSLIKLAAQD KDVTRIFVNP 180
  181 AIKQQLCLDA GTDRDWLRKV RPWFQHRAHM HVRLRCPADS LECEDQPLPP SGDGCGAELQ 240
  241 SWFEPPKPGT TKPEKKTPPP LPPSCQALLD EHVI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	109.0
Match:	1tzpA
Description:	MEPA, inactive form without ZN in P21
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.579809417316389	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: