YRC Public Data Repository - Protein Structure Prediction

Protein:	LEP_ECOLI
Organism:	Escherichia coli
Length:	324 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|81242142, gi\|... - gi\|82777994\|ref\|YP_404343.1\| lsignal peptidase I [Shigella dysenteriae Sd197], gi\|81242142\|gb\|ABB628...	326.0	[0..1]	[324..1]
gi\|194429296, gi... - gi\|75209492\|ref\|ZP_00709717.1\| COG0681: Signal peptidase I [Escherichia coli B171], gi\|194429296\|ref...	325.0	[0..1]	[324..1]
gi\|117624789, gi... - gi\|117624789\|ref\|YP_853702.1\| lsignal peptidase I [Escherichia coli APEC O1], gi\|115513913\|gb\|ABJ019... gi\|189378631, gi... - gi\|189378631\|gb\|EDU97047.1\| signal peptidase I [Escherichia coli O157:H7 str. EC508], gi\|168798951\|r... gi\|168778546, gi... - gi\|189003483\|gb\|EDU72469.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4076], gi\|168778546\|... gi\|195936715 - gi\|195936715\|ref\|ZP_03082097.1\| lsignal peptidase I [Escherichia coli O157:H7 str. EC4024] gi\|170517785, gi... - gi\|170680067\|ref\|YP_001744757.1\| signal peptidase I [Escherichia coli SMS-3-5], gi\|170517785\|gb\|ACB1... gi\|208733851, gi... - gi\|208812574\|ref\|ZP_03253903.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4045], gi\|208733... gi\|208806754, gi... - gi\|208806754\|ref\|ZP_03249091.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4206], gi\|208726... gi\|209400512, gi... - gi\|209400512\|ref\|YP_002272043.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4115], gi\|20916... gi\|208822004, gi... - gi\|208822004\|ref\|ZP_03262324.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4042], gi\|208742... gi\|110806513, gi... - gi\|110806513\|ref\|YP_690033.1\| lsignal peptidase I [Shigella flexneri 5 str. 8401], gi\|110616061\|gb\|A... gi\|188017088, gi... - gi\|188017088\|gb\|EDU55210.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4113], gi\|168748361\|... gi\|168761190, gi... - gi\|189368439\|gb\|EDU86855.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4501], gi\|168761190\|... gi\|91073469, gi\|... - gi\|91211895\|ref\|YP_541881.1\| lsignal peptidase I [Escherichia coli UTI89], gi\|91073469\|gb\|ABE08350.1... gi\|168757770, gi... - gi\|189355305\|gb\|EDU73724.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4401], gi\|168757770\|... gi\|13362905, gi\|... - gi\|15832688\|ref\|NP_311461.1\| signal peptidase I [Escherichia coli O157:H7 str. Sakai], gi\|13362905\|d... gi\|168773505, gi... - gi\|187770721\|gb\|EDU34565.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4196], gi\|168773505\|... gi\|110344322, gi... - gi\|110642730\|ref\|YP_670460.1\| signal peptidase I [Escherichia coli 536], gi\|110344322\|gb\|ABG70559.1\|... gi\|189362193, gi... - gi\|189362193\|gb\|EDU80612.1\| signal peptidase I [Escherichia coli O157:H7 str. EC4486], gi\|168768673\|... gi\|75237413 - gi\|75237413\|ref\|ZP_00721448.1\| COG0681: Signal peptidase I [Escherichia coli F11] gi\|193068340, gi... - gi\|75237686\|ref\|ZP_00721702.1\| COG0681: Signal peptidase I [Escherichia coli E110019], gi\|193068340\|... gi\|218706072, gi... - gi\|218706072\|ref\|YP_002413591.1\| signal peptidase I [Escherichia coli UMN026], gi\|218433169\|emb\|CAR1... gi\|193064078, gi... - gi\|75257992\|ref\|ZP_00729466.1\| COG0681: Signal peptidase I [Escherichia coli E22], gi\|193064078\|ref\|... gi\|82545020, gi\|... - gi\|82545020\|ref\|YP_408967.1\| lsignal peptidase I [Shigella boydii Sb227], gi\|81246431\|gb\|ABB67139.1\|... gi\|215487912, gi... - gi\|215487912\|ref\|YP_002330343.1\| signal peptidase I [Escherichia coli O127:H6 str. E2348/69], gi\|215... gi\|209920047, gi... - gi\|209920047\|ref\|YP_002294131.1\| signal peptidase I [Escherichia coli SE11], gi\|209913306\|dbj\|BAG783... gi\|218555149, gi... - gi\|218555149\|ref\|YP_002388062.1\| signal peptidase I [Escherichia coli IAI1], gi\|218361917\|emb\|CAQ995... gi\|194419637, gi... - gi\|83570804\|ref\|ZP_00922247.1\| COG0681: Signal peptidase I [Shigella dysenteriae 1012], gi\|194432108... gi\|217326961, gi... - gi\|217326961\|ref\|ZP_03443044.1\| signal peptidase I [Escherichia coli O157:H7 str. TW14588], gi\|21731... gi\|227835953, gi... - gi\|227887603\|ref\|ZP_04005408.1\| signal peptidase I [Escherichia coli 83972], gi\|227835953\|gb\|EEJ4641... gi\|83586780 - gi\|83586780\|ref\|ZP_00925411.1\| COG0681: Signal peptidase I [Escherichia coli 101-1] gi\|218690684, gi... - gi\|218690684\|ref\|YP_002398896.1\| signal peptidase I [Escherichia coli ED1a], gi\|218428248\|emb\|CAR091... gi\|237705078, gi... - gi\|237705078\|ref\|ZP_04535559.1\| signal peptidase I [Escherichia sp. 3_2_53FAA], gi\|226901444\|gb\|EEH8... gi\|187733350, gi... - gi\|75178163\|ref\|ZP_00698222.1\| COG0681: Signal peptidase I [Shigella boydii BS512], gi\|187733350\|ref... gi\|218366258, gi... - gi\|218559489\|ref\|YP_002392402.1\| signal peptidase I [Escherichia coli S88], gi\|218366258\|emb\|CAR0400... gi\|254289304, gi... - gi\|254289304\|ref\|YP_003055052.1\| leader peptidase (signal peptidase I) [Escherichia coli BL21(DE3)],... gi\|75187321, gi\|... - gi\|75187321\|ref\|ZP_00700588.1\| COG0681: Signal peptidase I [Escherichia coli E24377A], gi\|157156293\|... gi\|218701082, gi... - gi\|218701082\|ref\|YP_002408711.1\| signal peptidase I [Escherichia coli IAI39], gi\|218371068\|emb\|CAR18... gi\|253974444, gi... - gi\|254162543\|ref\|YP_003045651.1\| leader peptidase (signal peptidase I) [Escherichia coli B str. REL6... gi\|191167965, gi... - gi\|75228857\|ref\|ZP_00715458.1\| COG0681: Signal peptidase I [Escherichia coli B7A], gi\|191167965\|ref\|... gi\|218352928, gi... - gi\|218696196\|ref\|YP_002403863.1\| signal peptidase I [Escherichia coli 55989], gi\|218352928\|emb\|CAU98... gi\|254593919, gi... - gi\|254794519\|ref\|YP_003079356.1\| leader peptidase (signal peptidase I) [Escherichia coli O157:H7 str... gi\|24053011, gi\|... - gi\|24113910\|ref\|NP_708420.1\| lsignal peptidase I [Shigella flexneri 2a str. 301], gi\|24053011\|gb\|AAN... gi\|209762870, gi... - pir\|\|H85902 signal peptidase I (EC 3.4.21.89) [similarity] - Escherichia coli (strain O157:H7, subst... gi\|30042226, gi\|... - gi\|30063970\|ref\|NP_838141.1\| lsignal peptidase I [Shigella flexneri 2a str. 2457T], gi\|30042226\|gb\|A... gi\|26248933, gi\|... - gi\|26248933\|ref\|NP_754973.1\| lsignal peptidase I [Escherichia coli CFT073], gi\|26109339\|gb\|AAN81541.... gi\|15803095, gi\|... - gi\|15803095\|ref\|NP_289126.1\| lsignal peptidase I [Escherichia coli O157:H7 EDL933], gi\|12516986\|gb\|A... gi\|13362905, gi\|... - gi\|15832688\|ref\|NP_311461.1\| signal peptidase I [Escherichia coli O157:H7], gi\|13362905\|dbj\|BAB36857...	325.0	[0..1]	[324..1]
gi\|73856607, gi\|... - gi\|74313130\|ref\|YP_311549.1\| lsignal peptidase I [Shigella sonnei Ss046], gi\|73856607\|gb\|AAZ89314.1\|...	324.0	[0..1]	[324..1]
gi\|75196586, gi\|... - gi\|75196586\|ref\|ZP_00706656.1\| COG0681: Signal peptidase I [Escherichia coli HS], gi\|157162047\|ref\|Y...	324.0	[0..1]	[324..1]
gi\|161612649, gi... - gi\|161612649\|ref\|YP_001586614.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Pa... gi\|205325415, gi... - gi\|205325415\|gb\|EDZ13254.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Saintpau... gi\|167992713, gi... - gi\|205329087\|gb\|EDZ15851.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar 4,[5],12... gi\|204321328, gi... - gi\|204929609\|ref\|ZP_03220683.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Javi... gi\|205353678, gi... - gi\|205353678\|ref\|YP_002227479.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Gal... gi\|213052322 - gi\|213052322\|ref\|ZP_03345200.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Typ... gi\|213425275 - gi\|213425275\|ref\|ZP_03358025.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Typ... LEP_SALTY - Signal peptidase I OS=Salmonella typhimurium GN=lepB PE=3 SV=1 gi\|197214678, gi... - gi\|197250975\|ref\|YP_002147540.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Ago... gi\|197240708, gi... - gi\|197262453\|ref\|ZP_03162527.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Sain... gi\|198245898, gi... - gi\|198245898\|ref\|YP_002216649.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Dub... gi\|199605032, gi... - gi\|200387934\|ref\|ZP_03214546.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Virc... gi\|205341977, gi... - gi\|205341977\|gb\|EDZ28741.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Weltevre... gi\|194402478, gi... - gi\|194443815\|ref\|YP_002041845.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar New... gi\|194408226, gi... - gi\|194449922\|ref\|YP_002046644.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Hei... gi\|194459003, gi... - gi\|194472639\|ref\|ZP_03078623.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Kent... gi\|168232160, gi... - gi\|205333674\|gb\|EDZ20438.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Kentucky... gi\|205336136, gi... - gi\|205336136\|gb\|EDZ22900.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Heidelbe... gi\|168261367, gi... - gi\|205349570\|gb\|EDZ36201.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Hadar st... gi\|168466657, gi... - gi\|195630807\|gb\|EDX49399.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Newport ... gi\|224582876, gi... - gi\|224582876\|ref\|YP_002636674.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Par... gi\|62128780, gi\|... - gi\|62181147\|ref\|YP_217564.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Choler... gi\|213585349 - gi\|213585349\|ref\|ZP_03367175.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Typ... LEP_SALTY - Signal peptidase I OS=Salmonella typhimurium GN=lepB PE=3 SV=1 gi\|213613048 - gi\|213613048\|ref\|ZP_03370874.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Typ... gi\|213646352 - gi\|213646352\|ref\|ZP_03376405.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Typ... gi\|214000665 - gi\|214000665\|ref\|ZP_03411400.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Typ... lcl\|NC_016856.1_... - [gene=lepB] [protein=signal peptidase I] [protein_id=YP_005238689.1] [location=complement(2777334..2... gi\|238912700 - gi\|238912700\|ref\|ZP_04656537.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Ten... LEP_SALTI - Signal peptidase I OS=Salmonella typhi GN=lepB PE=3 SV=1 LEP_SALTI - Signal peptidase I OS=Salmonella typhi GN=lepB PE=3 SV=1 LEP_SALTY - Signal peptidase I OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=lepB PE=3 SV=1 gi\|29140809, gi\|... - gi\|29140809\|ref\|NP_804151.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Typhi ... gi\|16761494 - gi\|16761494\|ref\|NP_457111.1\| lsignal peptidase I [Salmonella enterica subsp. enterica serovar Typhi ...	319.0	[0..1]	[324..1]
gi\|197092953, gi... - gi\|197361477\|ref\|YP_002141113.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Par... gi\|56126799, gi\|... - gi\|56412542\|ref\|YP_149617.1\| signal peptidase I [Salmonella enterica subsp. enterica serovar Paratyp...	319.0	[0..1]	[324..1]
gi\|33332417 - gi\|33332417\|gb\|AAQ11415.1\| signal peptidase I [Yersinia enterocolitica]	314.0	[0..1]	[324..1]
gi\|186896304, gi... - gi\|186896304\|ref\|YP_001873416.1\| signal peptidase I [Yersinia pseudotuberculosis PB1/+], gi\|18669933... gi\|153950088, gi... - gi\|77629927\|ref\|ZP_00792513.1\| COG0681: Signal peptidase I [Yersinia pseudotuberculosis IP 31758], g...	314.0	[0..1]	[324..1]
gi\|238784186, gi... - gi\|77958590\|ref\|ZP_00822621.1\| COG0681: Signal peptidase I [Yersinia bercovieri ATCC 43970], gi\|2387...	314.0	[0..1]	[324..1]

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Predicted Domain #1

Region A:
Residues: [1-324]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANMFALILV IATLVTGILW CVDKFFFAPK RRERQAAAQA AAGDSLDKAT LKKVAPKPGW  60
   61 LETGASVFPV LAIVLIVRSF IYEPFQIPSG SMMPTLLIGD FILVEKFAYG IKDPIYQKTL 120
  121 IETGHPKRGD IVVFKYPEDP KLDYIKRAVG LPGDKVTYDP VSKELTIQPG CSSGQACENA 180
  181 LPVTYSNVEP SDFVQTFSRR NGGEATSGFF EVPKNETKEN GIRLSERKET LGDVTHRILT 240
  241 VPIAQDQVGM YYQQPGQQLA TWIVPPGQYF MMGDNRDNSA DSRYWGFVPE ANLVGRATAI 300
  301 WMSFDKQEGE WPTGLRLSRI GGIH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.09691
Match:	1t7dA
Description:	Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	0.485843348899278	bayes_pls_golite062009
catalytic activity	0.415601732277814	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.237734983138449	bayes_pls_golite062009
hydrolase activity	0.188292586303013	bayes_pls_golite062009
protein binding	0.0579980138351139	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: