YRC Public Data Repository - Protein Structure Prediction

Protein:	KDSA_ECOLI
Organism:	Escherichia coli
Length:	284 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KDSA_ECOLI.

Description	E-value	Query Range	Subject Range
KDSA_MANSM - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Mannheimia succiniciproducens (strain MBEL55E) GN=kdsA ...	317.0	[0..1]	[284..1]
KDSA_ACTSZ - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Actinobacillus succinogenes (strain ATCC 55618 / 130Z) ...	315.0	[0..1]	[284..1]
KDSA_HISS2 - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Histophilus somni (strain 2336) GN=kdsA PE=3 SV=1	314.0	[0..1]	[283..1]
KDSA_HAES1 - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Haemophilus somnus (strain 129Pt) GN=kdsA PE=3 SV=1	313.0	[0..1]	[283..1]
KDSA_PHOLL - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Photorhabdus luminescens subsp. laumondii GN=kdsA PE=3 ... KDSA_PHOLL - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 1...	313.0	[0..1]	[284..1]
KDSA_PECAS - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BA... KDSA_ERWCT - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Erwinia carotovora subsp. atroseptica GN=kdsA PE=3 SV=1	313.0	[0..1]	[283..1]
KDSA_MANHA - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Mannheimia haemolytica GN=kdsA PE=3 SV=1	312.0	[0..1]	[284..1]
gi\|126209494, gi... - gi\|126209494\|ref\|YP_001054719.1\| 2-dehydro-3-deoxyphosphooctonate aldolase [Actinobacillus pleuropne... gi\|32033822 - gi\|32033822\|ref\|ZP_00134107.1\| COG2877: 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase ... KDSA_ACTP7 - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Actinobacillus pleuropneumoniae serotype 7 (strain AP76...	312.0	[0..1]	[283..1]
gi\|42631609 - gi\|42631609\|ref\|ZP_00157147.1\| COG2877: 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase ... gi\|145639099, gi... - gi\|145639099\|ref\|ZP_01794707.1\| 2-dehydro-3-deoxyphosphooctonate aldolase [Haemophilus influenzae Pi... gi\|144978068, gi... - gi\|145629731\|ref\|ZP_01785527.1\| 2-dehydro-3-deoxyphosphooctonate aldolase [Haemophilus influenzae 22...	312.0	[0..1]	[283..1]
KDSA_HAEIN - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Haemophilus influenzae GN=kdsA PE=1 SV=1 KDSA_HAEIN - 2-dehydro-3-deoxyphosphooctonate aldolase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 /...	312.0	[0..1]	[283..1]

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Predicted Domain #1

Region A:
Residues: [1-284]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQKVVSIGD INVANDLPFV LFGGMNVLES RDLAMRICEH YVTVTQKLGI PYVFKASFDK  60
   61 ANRSSIHSYR GPGLEEGMKI FQELKQTFGV KIITDVHEPS QAQPVADVVD VIQLPAFLAR 120
  121 QTDLVEAMAK TGAVINVKKP QFVSPGQMGN IVDKFKEGGN EKVILCDRGA NFGYDNLVVD 180
  181 MLGFSIMKKV SGNSPVIFDV THALQCRDPF GAASGGRRAQ VAELARAGMA VGLAGLFIEA 240
  241 HPDPEHAKCD GPSALPLAKL EPFLKQMKAI DDLVKGFEEL DTSK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.69897
Match:	1d9eA
Description:	3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8P synthase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-deoxy-8-phosphooctulonate synthase activity	4.43037733440316	bayes_pls_golite062009
3-deoxy-7-phosphoheptulonate synthase activity	2.72022882819661	bayes_pls_golite062009
catalytic activity	2.67031204377352	bayes_pls_golite062009
fructose-bisphosphate aldolase activity	0.840107349031025	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	0.643395146148785	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	0.490222900376021	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
aldehyde-lyase activity	0.351872954170322	bayes_pls_golite062009
transaldolase activity	0.337067552042715	bayes_pls_golite062009
oxo-acid-lyase activity	0.0484922693826344	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: