YRC Public Data Repository - Protein Structure Prediction

Protein:	ISPH_ECOLI
Organism:	Escherichia coli
Length:	316 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISPH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77961930 - gi\|77961930\|ref\|ZP_00825758.1\| COG0761: Penicillin tolerance protein [Yersinia mollaretii ATCC 43969...	497.0	[0..1]	[316..1]
gi\|26106347, gi\|... - gi\|26245950\|ref\|NP_751989.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Escherichia coli CF...	497.0	[0..1]	[316..16]
gi\|77959747 - gi\|77959747\|ref\|ZP_00823764.1\| COG0761: Penicillin tolerance protein [Yersinia bercovieri ATCC 43970...	496.0	[0..1]	[316..1]
gi\|77976918 - gi\|77976918\|ref\|ZP_00832383.1\| COG0761: Penicillin tolerance protein [Yersinia intermedia ATCC 29909...	496.0	[0..1]	[316..1]
ISPH_ERWCT - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Erwinia carotovora subsp. atroseptica GN=ispH ... ISPH_PECAS - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Pectobacterium atrosepticum (strain SCRI 1043 ...	496.0	[0..1]	[316..1]
gi\|77976148 - gi\|77976148\|ref\|ZP_00831681.1\| COG0761: Penicillin tolerance protein [Yersinia frederiksenii ATCC 33...	496.0	[0..1]	[316..1]
gi\|22127571, gi\|... - gi\|22127571\|ref\|NP_670994.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis KIM... gi\|45443434, gi\|... - gi\|45443434\|ref\|NP_994973.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis bio...	496.0	[0..1]	[316..9]
ISPH_PSEE4 - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Pseudomonas entomophila (strain L48) GN=ispH P... gi\|95112630 - gi\|95112630\|emb\|CAK17358.1\| hydroxymethylbutenyl pyrophosphate reductase [Pseudomonas entomophila L4...	495.0	[0..1]	[310..1]
gi\|166009038, gi... - gi\|166009038\|ref\|ZP_02229936.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis ... ISPH_YERPG - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Yersinia pestis bv. Antiqua (strain Angola) GN... gi\|165927279, gi... - gi\|165927279\|ref\|ZP_02223111.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis ... gi\|165914247, gi... - gi\|89102799\|ref\|ZP_01175408.1\| COG0761: Penicillin tolerance protein [Yersinia pestis biovar Orienta... gi\|167401592, gi... - gi\|167401592\|ref\|ZP_02307086.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis ... ISPH_YERPA - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Yersinia pestis bv. Antiqua (strain Antiqua) G... gi\|166206751, gi... - gi\|166212005\|ref\|ZP_02238040.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis ... gi\|167054938, gi... - gi\|167426015\|ref\|ZP_02317768.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis ... ISPH_YERPE - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Yersinia pestis GN=ispH PE=3 SV=1 gi\|167419149, gi... - gi\|167419149\|ref\|ZP_02310902.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis ... gi\|150260486, gi... - gi\|150260486\|ref\|ZP_01917214.1\| LytB protein [Yersinia pestis CA88-4125], gi\|149289894\|gb\|EDM39971.1... ISPH_YERPP - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Yersinia pestis (strain Pestoides F) GN=ispH P... gi\|167469835 - gi\|167469835\|ref\|ZP_02334539.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis ... ISPH_YERPN - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Yersinia pestis bv. Antiqua (strain Nepal516) ... gi\|161511299 - gi\|161511299\|ref\|NP_994973.2\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis bi... gi\|161484743 - gi\|161484743\|ref\|NP_670994.2\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis KI... gi\|15978571, gi\|... - gi\|218927675\|ref\|YP_002345550.1\| 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Yersinia pestis... gi\|229836940, gi... - gi\|229836940\|ref\|ZP_04457105.1\| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S pro... gi\|229840365, gi... - gi\|229840365\|ref\|ZP_04460524.1\| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S pro... gi\|229842445, gi... - gi\|229842445\|ref\|ZP_04462600.1\| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S pro...	494.0	[0..1]	[316..1]
ISPH_YERPS - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Yersinia pseudotuberculosis serotype I (strain... ISPH_YERPS - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Yersinia pseudotuberculosis GN=ispH PE=3 SV=1 ISPH_YERPB - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Yersinia pseudotuberculosis serotype IB (strai... ISPH_YERPY - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase OS=Yersinia pseudotuberculosis serotype O:3 (stra...	494.0	[0..1]	[316..1]

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Predicted Domain #1

Region A:
Residues: [1-76]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQILLANPRG FCAGVDRAIS IVENALAIYG APIYVRHEVV HNRYVVDSLR ERGAIFIEQI  60
   61 SEVPDGAILI FSAHGV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [77-158]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQAVRNEAKS RDLTVFDATC PLVTKVHMEV ARASRRGEES ILIGHAGHPE VEGTMGQYSN  60
   61 PEGGMYLVES PDDVWKLTVK NE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [159-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKLSFMTQTT LSVDDTSDVI DALRKRFPKI VGPRKDDICY ATTNRQEAVR ALAEQAEVVL  60
   61 VVGSKNSSNS NRLAELAQRM GKRAFLIDDA KDIQEEWVKE VKCVGVTAGA SAPDILVQNV 120
  121 VARLQQLGGG EAIPLEGREE NIVFEVPKEL RVDIREVD

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.951	0.876	terpenoid biosynthetic process	c.2.1	NAD(P)-binding Rossmann-fold domains

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits