YRC Public Data Repository - Protein Structure Prediction

Protein:	INTE_ECOLI
Organism:	Escherichia coli
Length:	375 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INTE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|227886506, gi... - gi\|227886506\|ref\|ZP_04004311.1\| prophage lambda integrase [Escherichia coli 83972], gi\|227836710\|gb\|... gi\|26247388, gi\|... - gi\|26247388\|ref\|NP_753428.1\| prophage lambda integrase [Escherichia coli CFT073], gi\|26107789\|gb\|AAN...	193.0	[0..1]	[370..1]
gi\|218364788, gi... - gi\|218558019\|ref\|YP_002390932.1\| phage integrase [Escherichia coli S88], gi\|218364788\|emb\|CAR02478.1... gi\|91210294, gi\|... - gi\|91210294\|ref\|YP_540280.1\| prophage lambda integrase [Escherichia coli UTI89], gi\|91071868\|gb\|ABE0... gi\|117623322, gi... - gi\|117623322\|ref\|YP_852235.1\| prophage lambda integrase [Escherichia coli APEC O1], gi\|115512446\|gb\|... gi\|237706877, gi... - gi\|237706877\|ref\|ZP_04537358.1\| prophage lambda integrase [Escherichia sp. 3_2_53FAA], gi\|226898087\|...	192.0	[0..1]	[370..1]
gi\|75194504, gi\|... - gi\|75194504\|ref\|ZP_00704574.1\| COG0582: Integrase [Escherichia coli HS], gi\|157159783\|ref\|YP_0014571...	192.0	[0..2]	[375..10]
gi\|215450 - gi\|215450\|gb\|AAA32336.1\| integrase [Bacteriophage 21] gi\|16209114 - gi\|16209114\|gb\|AAL09876.1\| integrase [CRIM helper plasmid pAH122] VINT_BPP21 - Integrase OS=Enterobacteria phage P21 GN=int PE=3 SV=1 gi\|16209107 - gi\|16209107\|gb\|AAL09871.1\| integrase [CRIM helper plasmid pAH121]	192.0	[0..1]	[370..1]
gi\|190902162, gi... - gi\|75229050\|ref\|ZP_00715634.1\| COG0582: Integrase [Escherichia coli B7A], gi\|191167819\|ref\|ZP_030296...	191.0	[0..3]	[375..11]
gi\|208815352, gi... - gi\|208815352\|ref\|ZP_03256531.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC4045], gi... gi\|208806721, gi... - gi\|208806721\|ref\|ZP_03249058.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC4206], gi... gi\|13361073, gi\|... - gi\|15830863\|ref\|NP_309636.1\| intergrase [Escherichia coli O157:H7], gi\|13361073\|dbj\|BAB35032.1\| inte... gi\|195938769 - gi\|195938769\|ref\|ZP_03084151.1\| intergrase [Escherichia coli O157:H7 str. EC4024] gi\|25301770, gi\|... - pir\|\|G85687 probable integrase of prophage CP-933X Z1866 [imported] - Escherichia coli (strain O157:... gi\|189377300, gi... - gi\|189377300\|gb\|EDU95716.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC508], gi\|1688... gi\|12514791, gi\|... - gi\|15801334\|ref\|NP_287351.1\| putative integrase of prophage CP-933X [Escherichia coli O157:H7 EDL933... gi\|217328258, gi... - gi\|217328258\|ref\|ZP_03444340.1\| intergrase [Escherichia coli O157:H7 str. TW14588], gi\|217318685\|gb\|... gi\|209396519, gi... - gi\|209396519\|ref\|YP_002270055.1\| intergrase [Escherichia coli O157:H7 str. EC4115], gi\|209157919\|gb\|... gi\|208822097, gi... - gi\|208822097\|ref\|ZP_03262416.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC4042], gi... gi\|168762555, gi... - gi\|189367182\|gb\|EDU85598.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC4501], gi\|168... gi\|189356364, gi... - gi\|189356364\|gb\|EDU74783.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC4401], gi\|168... gi\|168749741, gi... - gi\|188015991\|gb\|EDU54113.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC4113], gi\|168... gi\|168787614, gi... - gi\|189372539\|gb\|EDU90955.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC869], gi\|1687... gi\|168782475, gi... - gi\|189000064\|gb\|EDU69050.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC4076], gi\|168... gi\|168776049, gi... - gi\|187768527\|gb\|EDU32371.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC4196], gi\|168... gi\|189360144, gi... - gi\|189360144\|gb\|EDU78563.1\| prophage lambda integrase [Escherichia coli O157:H7 str. EC4486], gi\|168... gi\|254792597, gi... - gi\|254792597\|ref\|YP_003077434.1\| putative integrase of prophage CP-933X [Escherichia coli O157:H7 st... gi\|13361073, gi\|... - gi\|15830863\|ref\|NP_309636.1\| intergrase [Escherichia coli O157:H7 str. Sakai], gi\|13361073\|dbj\|BAB35...	190.0	[0..1]	[370..1]
gi\|24114927, gi\|... - gi\|24114927\|ref\|NP_709437.1\| putative integrase [Shigella flexneri 2a str. 301], gi\|24054171\|gb\|AAN4... gi\|30065067, gi\|... - gi\|30065067\|ref\|NP_839238.1\| putative integrase [Shigella flexneri 2a str. 2457T], gi\|30043328\|gb\|AA... gi\|5880470 - gi\|5880470\|gb\|AAD54663.1\|AF097520_1 Sai integrase [Shigella flexneri]	189.0	[0..3]	[375..20]
gi\|77974232, gi\|... - gi\|77974232\|ref\|ZP_00829773.1\| COG0582: Integrase [Yersinia frederiksenii ATCC 33641], gi\|238790928\|...	189.0	[0..3]	[375..11]
gi\|62127393, gi\|... - gi\|62179760\|ref\|YP_216177.1\| prophage lambda integrase (Int(lambda)) [Salmonella enterica subsp. ent...	188.0	[0..1]	[362..1]
gi\|77545197, gi\|... - gi\|77919114\|ref\|YP_356929.1\| site-specific recombinase [Pelobacter carbinolicus DSM 2380], gi\|775451...	188.0	[0..88]	[371..1]

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Predicted Domain #1

Region A:
Residues: [1-375]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAARPRKNNV SVPNLYPLYS RKVNKVYWRY KHPVTGKFHA LGTNEAEAIA IATEANTRLA  60
   61 EQRTRQILAI SDRIATSKGK AITTSTWLDR YQAIQDDRLK SGDIRLNTYK QKAKPVSLLR 120
  121 ERAGMKLISA VDVRDIAQLL DEYIAAGRPR MAQVVRSVLI DVFKEAQHYG EVPPGYNPAL 180
  181 ATKQPRRKIT RQRLSLEEWK KIFDIADATH RYMGNAMLLA LVTGQRLGDI SRMKFSDIWD 240
  241 DHLHVIQEKT GSKIAIPLSL RLNAINWSLR DVVARCRDYA VSAYLVHFFR STSQAERGAQ 300
  301 VKANTLTMNF SKARDLARID WGEGSPATFH EQRSLSERLY KEQGLDTQKL LGHKTQQQTD 360
  361 RYHDDRGKGW SKVAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.39794
Match:	1z1bA
Description:	Crystal structure of a lambda integrase dimer bound to a COC' core site
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
site-specific recombinase activity	4.99325011803106	bayes_pls_golite062009
integrase activity	3.60695091575172	bayes_pls_golite062009
catalytic activity	2.22520758916604	bayes_pls_golite062009
structure-specific DNA binding	0.11292854906722	bayes_pls_golite062009
DNA binding	0.10970863758177	bayes_pls_golite062009
nucleic acid binding	0.06580979261817	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: