YRC Public Data Repository - Protein Structure Prediction

Protein:	IMDH_ECOLI
Organism:	Escherichia coli
Length:	488 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IMDH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|112822609, gi... - gi\|113460566\|ref\|YP_718630.1\| inositol-5-monophosphate dehydrogenase [Haemophilus somnus 129PT], gi\|...	462.0	[0..1]	[487..1]
gi\|168827042, gi... - gi\|53728499\|ref\|ZP_00132545.2\| COG0516: IMP dehydrogenase/GMP reductase [Haemophilus somnus 2336], g...	460.0	[0..1]	[487..1]
gi\|166853413, gi... - gi\|167039173\|ref\|YP_001662158.1\| response regulator receiver protein [Thermoanaerobacter sp. X514], ... gi\|167038115, gi... - gi\|76796702\|ref\|ZP_00779057.1\| IMP dehydrogenase [Thermoanaerobacter ethanolicus ATCC 33223], gi\|765... gi\|241902681, gi... - gi\|241902681\|ref\|ZP_04787413.1\| inosine-5'-monophosphate dehydrogenase [Thermoanaerobacter brockii s...	457.0	[0..3]	[486..4]
gi\|89158560, gi\|... - gi\|89211833\|ref\|ZP_01190168.1\| IMP dehydrogenase [Halothermothrix orenii H 168], gi\|89158560\|gb\|EAR7...	456.0	[0..1]	[487..1]
gi\|52424829, gi\|... - gi\|52424829\|ref\|YP_087966.1\| inositol-5-monophosphate dehydrogenase [Mannheimia succiniciproducens M...	455.0	[0..1]	[487..1]
gi\|20807078, gi\|... - gi\|20807078\|ref\|NP_622249.1\| IMP dehydrogenase/GMP reductase [Thermoanaerobacter tengcongensis MB4],... gi\|20807078 - gi\|20807078\|ref\|NP_622249.1\| IMP dehydrogenase/GMP reductase [Thermoanaerobacter tengcongensis MB4]	454.0	[0..2]	[486..3]
IMDH_PASMU - Inosine-5'-monophosphate dehydrogenase OS=Pasteurella multocida GN=guaB PE=3 SV=1 IMDH_PASMU - Inosine-5'-monophosphate dehydrogenase OS=Pasteurella multocida (strain Pm70) GN=guaB PE=3 SV=1	453.0	[0..1]	[487..1]
gi\|74276714, gi\|... - gi\|75430067\|ref\|ZP_00732606.1\| IMP dehydrogenase [Actinobacillus succinogenes 130Z], gi\|74276714\|gb\|...	453.0	[0..2]	[487..3]
gi\|27363887, gi\|... - gi\|27363887\|ref\|NP_759415.1\| inositol-5-monophosphate dehydrogenase [Vibrio vulnificus CMCP6], gi\|27...	450.0	[0..1]	[487..1]
gi\|82500120, gi\|... - gi\|82500120\|ref\|ZP_00885547.1\| IMP dehydrogenase [Caldicellulosiruptor saccharolyticus DSM 8903], gi...	450.0	[0..2]	[486..5]

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Predicted Domain #1

Region A:
Residues: [1-488]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRIAKEALT FDDVLLVPAH STVLPNTADL STQLTKTIRL NIPMLSAAMD TVTEARLAIA  60
   61 LAQEGGIGFI HKNMSIERQA EEVRRVKKHE SGVVTDPQTV LPTTTLREVK ELTERNGFAG 120
  121 YPVVTEENEL VGIITGRDVR FVTDLNQPVS VYMTPKERLV TVREGEAREV VLAKMHEKRV 180
  181 EKALVVDDEF HLIGMITVKD FQKAERKPNA CKDEQGRLRV GAAVGAGAGN EERVDALVAA 240
  241 GVDVLLIDSS HGHSEGVLQR IRETRAKYPD LQIIGGNVAT AAGARALAEA GCSAVKVGIG 300
  301 PGSICTTRIV TGVGVPQITA VADAVEALEG TGIPVIADGG IRFSGDIAKA IAAGASAVMV 360
  361 GSMLAGTEES PGEIELYQGR SYKSYRGMGS LGAMSKGSSD RYFQSDNAAD KLVPEGIEGR 420
  421 VAYKGRLKEI IHQQMGGLRS CMGLTGCGTI DELRTKAEFV RISGAGIQES HVHDVTITKE 480
  481 SPNYRLGS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	124.0
Match:	1vrdA
Description:	Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.251087581516086	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: