YRC Public Data Repository - Protein Structure Prediction

Protein:	HYCB_ECOLI
Organism:	Escherichia coli
Length:	203 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HYCB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|71282673, gi\|... - gi\|71482494\|ref\|ZP_00662180.1\| 4Fe-4S ferredoxin, iron-sulfur binding:Polysulphide reductase, NrfD [...	157.0	[0..1]	[201..22]
gi\|189339739, gi... - gi\|67918570\|ref\|ZP_00512166.1\| 4Fe-4S ferredoxin, iron-sulfur binding:Polysulphide reductase, NrfD [...	153.0	[0..1]	[191..1]
gi\|148655927, gi... - gi\|148655927\|ref\|YP_001276132.1\| 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein [Ro...	152.0	[0..2]	[191..3]
gi\|108763060, gi... - gi\|108763060\|ref\|YP_634214.1\| putative molybdopterin oxidoreductase, iron-sulfur binding subunit [My...	151.0	[0..2]	[190..819]
gi\|68553334, gi\|... - gi\|68553334\|ref\|ZP_00592711.1\| 4Fe-4S ferredoxin, iron-sulfur binding:Polysulphide reductase, NrfD [...	150.0	[0..1]	[201..86]
gi\|74313291, gi\|... - gi\|74313291\|ref\|YP_311710.1\| small subunit of hydrogenase-3, iron-sulfur protein [Shigella sonnei Ss...	150.0	[0..1]	[203..1]
gi\|78165820, gi\|... - gi\|78185918\|ref\|YP_373961.1\| Fe-S-cluster-containing hydrogenase components 1-like [Pelodictyon lute...	149.0	[0..1]	[201..1]
gi\|77164744, gi\|... - gi\|77164744\|ref\|YP_343269.1\| molybdopterin oxidoreductase, iron-sulfur binding subunit [Nitrosococcu...	149.0	[0..3]	[190..760]
gi\|81242238, gi\|... - gi\|82778090\|ref\|YP_404439.1\| small subunit of hydrogenase-3, iron-sulfur protein [Shigella dysenteri... gi\|209761858, gi... - pir\|\|D91076 formate hydrogenlyase subunit-7 component B [imported] - Escherichia coli (strain O157:H... gi\|168778706, gi... - gi\|189003372\|gb\|EDU72358.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC4076],... gi\|168774744, gi... - gi\|187769642\|gb\|EDU33486.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC4196],... gi\|254594064, gi... - gi\|254794664\|ref\|YP_003079501.1\| hydrogenase 3, Fe-S subunit [Escherichia coli O157:H7 str. TW14359]... gi\|15803241, gi\|... - gi\|15803241\|ref\|NP_289273.1\| small subunit of hydrogenase-3, iron-sulfur protein (part of formate hy... gi\|168768815, gi... - gi\|189362046\|gb\|EDU80465.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC4486],... gi\|13363051, gi\|... - gi\|15832834\|ref\|NP_311607.1\| formate hydrogenlyase subunit-7 component B [Escherichia coli O157:H7],... gi\|168762877, gi... - gi\|189366874\|gb\|EDU85290.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC4501],... gi\|193065023, gi... - gi\|193065023\|ref\|ZP_03046098.1\| formate hydrogenlyase, subunit B [Escherichia coli E22], gi\|19292732... gi\|13363051, gi\|... - gi\|15832834\|ref\|NP_311607.1\| formate hydrogenlyase subunit-7 component B [Escherichia coli O157:H7 s... gi\|191166789, gi... - gi\|191166789\|ref\|ZP_03028615.1\| formate hydrogenlyase, subunit B [Escherichia coli B7A], gi\|19090316... gi\|168800195, gi... - gi\|189377473\|gb\|EDU95889.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC508], ... gi\|189372240, gi... - gi\|189372240\|gb\|EDU90656.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC869], ... gi\|168755469, gi... - gi\|189357280\|gb\|EDU75699.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC4401],... gi\|168749951, gi... - gi\|188015781\|gb\|EDU53903.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC4113],... gi\|218696318, gi... - gi\|218696318\|ref\|YP_002403985.1\| hydrogenase 3, Fe-S subunit [Escherichia coli 55989], gi\|218353050\|... gi\|218362036, gi... - gi\|218555268\|ref\|YP_002388181.1\| hydrogenase 3, Fe-S subunit [Escherichia coli IAI1], gi\|218362036\|e... gi\|217319719, gi... - gi\|217327352\|ref\|ZP_03443435.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. TW14... gi\|208808306, gi... - gi\|208808306\|ref\|ZP_03250643.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC42... gi\|195938474 - gi\|195938474\|ref\|ZP_03083856.1\| formate hydrogenlyase subunit-7 component B [Escherichia coli O157:H... gi\|194427877, gi... - gi\|194427877\|ref\|ZP_03060423.1\| formate hydrogenlyase, subunit B [Escherichia coli B171], gi\|1944141... gi\|193069629, gi... - gi\|193069629\|ref\|ZP_03050581.1\| formate hydrogenlyase, subunit B [Escherichia coli E110019], gi\|1929... gi\|209920163, gi... - gi\|209920163\|ref\|YP_002294247.1\| formate hydrogenlyase subunit [Escherichia coli SE11], gi\|209913422... gi\|209160468, gi... - gi\|209399068\|ref\|YP_002272187.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC4... gi\|208820193, gi... - gi\|208820193\|ref\|ZP_03260513.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC40... gi\|208735402, gi... - gi\|208814125\|ref\|ZP_03255454.1\| formate hydrogenlyase, subunit B [Escherichia coli O157:H7 str. EC40...	149.0	[0..1]	[203..1]
gi\|115514080, gi... - gi\|117624956\|ref\|YP_853944.1\| hydrogenase 3, Fe-S subunit [Escherichia coli APEC O1], gi\|115514080\|g... gi\|237706652, gi... - gi\|237706652\|ref\|ZP_04537133.1\| hydrogenase 3 [Escherichia sp. 3_2_53FAA], gi\|226899692\|gb\|EEH85951.... gi\|218559714, gi... - gi\|218559714\|ref\|YP_002392627.1\| hydrogenase 3, Fe-S subunit [Escherichia coli S88], gi\|218366483\|em... gi\|91212084, gi\|... - gi\|91212084\|ref\|YP_542070.1\| formate hydrogenlyase subunit 2 [Escherichia coli UTI89], gi\|91073658\|g...	149.0	[0..1]	[203..1]

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Predicted Domain #1

Region A:
Residues: [1-203]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRFVIADST LCIGCHTCEA ACSETHRQHG LQSMPRLRVM LNEKESAPQL CHHCEDAPCA  60
   61 VVCPVNAITR VDGAVQLNES LCVSCKLCGI ACPFGAIEFS GSRPLDIPAN ANTPKAPPAP 120
  121 PAPARVSTLL DWVPGIRAIA VKCDLCSFDE QGPACVRMCP TKALHLVDNT DIARVSKRKR 180
  181 ELTFNTDFGD LTLFQQAQSG EAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.39794
Match:	1kqfB
Description:	Formate dehydrogenase N, iron-sulfur (beta) subunit; Iron-sulfur subunit of formate dehydrogenase N, transmembrane anchor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
formate dehydrogenase activity	10.9674358961972	bayes_pls_golite062009
oxidoreductase activity	5.98361135786786	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	5.77927347135001	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	5.39747453448396	bayes_pls_golite062009
electron carrier activity	5.05393703018095	bayes_pls_golite062009
NADH dehydrogenase activity	3.13953145151561	bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity	2.76338281383262	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	2.70037803782769	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	2.09041948600744	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.80621486978907	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	1.5619384041388	bayes_pls_golite062009
iron-sulfur cluster binding	1.30496569995148	bayes_pls_golite062009
metal cluster binding	1.30496569995148	bayes_pls_golite062009
catalytic activity	0.488483980994331	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: