YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS6_ECOLI
Organism:	Escherichia coli
Length:	258 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS6_ECOLI.

Description	E-value	Query Range	Subject Range
HIS6_PELTS - Imidazole glycerol phosphate synthase subunit HisF OS=Pelotomaculum thermopropionicum (strain DSM 13...	256.0	[0..1]	[257..1]
HIS6_NITEC - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas eutropha (strain C91) GN=hisF PE=...	254.0	[0..2]	[257..3]
gi\|94499843, gi\|... - gi\|94499843\|ref\|ZP_01306379.1\| Imidazoleglycerol-phosphate synthase [Oceanobacter sp. RED65], gi\|944...	251.0	[0..2]	[257..3]
gi\|89083520, gi\|... - gi\|89092432\|ref\|ZP_01165386.1\| imidazole glycerol phosphate synthase subunit HisF [Oceanospirillum s...	251.0	[0..2]	[257..3]
HIS6_THETN - Imidazole glycerol phosphate synthase subunit hisF OS=Thermoanaerobacter tengcongensis GN=hisF PE=3 ... HIS6_CALS4 - Imidazole glycerol phosphate synthase subunit HisF OS=Caldanaerobacter subterraneus subsp. tengconge...	251.0	[0..1]	[257..1]
HIS6_GEOUR - Imidazole glycerol phosphate synthase subunit HisF OS=Geobacter uraniireducens (strain Rf4) GN=hisF ...	251.0	[0..1]	[257..1]
gi\|110604130, gi... - gi\|110604130\|ref\|ZP_01392203.1\| imidazoleglycerol phosphate synthase, cyclase subunit [Methanoculleu...	251.0	[0..2]	[257..121]
HIS6_NITEU - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas europaea GN=hisF PE=3 SV=1 HIS6_NITEU - Imidazole glycerol phosphate synthase subunit HisF OS=Nitrosomonas europaea (strain ATCC 19718 / NBR...	251.0	[0..2]	[257..3]
HIS6_PSEA7 - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas aeruginosa (strain PA7) GN=hisF PE...	251.0	[0..2]	[256..3]
HIS6_PSEAB - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=... HI61_PSEAE, HIS6... - Imidazole glycerol phosphate synthase subunit hisF1 OS=Pseudomonas aeruginosa GN=hisF1 PE=3 SV=1, (Q... HIS61_PSEAE - Imidazole glycerol phosphate synthase subunit hisF1 OS=Pseudomonas aeruginosa (strain ATCC 15692 / P... HIS6_PSEA8 - Imidazole glycerol phosphate synthase subunit HisF OS=Pseudomonas aeruginosa (strain LESB58) GN=hisF... gi\|107104236 - gi\|107104236\|ref\|ZP_01368154.1\| hypothetical protein PaerPA_01005309 [Pseudomonas aeruginosa PACS2] gi\|254238158, gi... - gi\|84317792\|ref\|ZP_00966229.1\| COG0107: Imidazoleglycerol-phosphate synthase [Pseudomonas aeruginosa... gi\|84323776, gi\|... - gi\|84323776\|ref\|ZP_00971843.1\| COG0107: Imidazoleglycerol-phosphate synthase [Pseudomonas aeruginosa...	251.0	[0..2]	[256..3]

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Predicted Domain #1

Region A:
Residues: [1-258]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAKRIIPCL DVRDGQVVKG VQFRNHEIIG DIVPLAKRYA EEGADELVFY DITASSDGRV  60
   61 VDKSWVSRVA EVIDIPFCVA GGIKSLEDAA KILSFGADKI SINSPALADP TLITRLADRF 120
  121 GVQCIVVGID TWYDAETGKY HVNQYTGDES RTRVTQWETL DWVQEVQKRG AGEIVLNMMN 180
  181 QDGVRNGYDL EQLKKVREVC HVPLIASGGA GTMEHFLEAF RDADVDGALA ASVFHKQIIN 240
  241 IGELKAYLAT QGVEIRIC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.30103
Match:	2a0nA
Description:	Crystal structure of Imidazole glycerol phosphate synthase subunit hisF (EC 4.1.3.-) (tm1036) from Thermotoga maritima at 1.64 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate synthase activity	8.63799159510181	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	1.13340776845419	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	0.549444136526559	bayes_pls_golite062009
tryptophan synthase activity	0.426391242491024	bayes_pls_golite062009
lyase activity	0.258652421339738	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: