YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS2_ECOLI
Organism:	Escherichia coli
Length:	203 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS2_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|116220453, gi... - gi\|75819710\|ref\|ZP_00749778.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Vibrio cholerae V51], gi\|...	288.0	[0..6]	[203..10]
gi\|41700 - gi\|41700\|emb\|CAA27613.1\| unnamed protein product [Escherichia coli]	287.0	[0..1]	[203..1]
gi\|229370940, gi... - gi\|229608285\|ref\|YP_002878933.1\| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatas... HIS2_VIBCH - Histidine biosynthesis bifunctional protein HisIE OS=Vibrio cholerae GN=hisI PE=3 SV=1 gi\|121587405, gi... - gi\|121587405\|ref\|ZP_01677174.1\| phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase... gi\|124119019, gi... - gi\|153222277\|ref\|ZP_01953037.1\| phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase... gi\|126512535, gi... - gi\|153816948\|ref\|ZP_01969615.1\| phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase... gi\|126520460, gi... - gi\|229511064\|ref\|ZP_04400543.1\| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase... gi\|75826492, gi\|... - gi\|75826492\|ref\|ZP_00755927.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Vibrio cholerae O395], gi... gi\|121631238, gi... - gi\|75817342\|ref\|ZP_00747794.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Vibrio cholerae V52], gi\|... gi\|227081312, gi... - gi\|227081312\|ref\|YP_002809863.1\| phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolas... gi\|229505266, gi... - gi\|229505266\|ref\|ZP_04394776.1\| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase... HIS2_VIBCH - Histidine biosynthesis bifunctional protein HisIE OS=Vibrio cholerae serotype O1 (strain ATCC 39315 ... gi\|229518184, gi... - gi\|229518184\|ref\|ZP_04407628.1\| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase... gi\|197751091, gi... - gi\|254291564\|ref\|ZP_04962354.1\| phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase... gi\|229520431, gi... - gi\|229520431\|ref\|ZP_04409856.1\| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase... gi\|148875861, gi... - gi\|153828708\|ref\|ZP_01981375.1\| phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase... gi\|229339331, gi... - gi\|229525750\|ref\|ZP_04415155.1\| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase... gi\|116188983, gi... - gi\|75830132\|ref\|ZP_00759416.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Vibrio cholerae MO10], gi... gi\|149740251, gi... - gi\|153826031\|ref\|ZP_01978698.1\| phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase... gi\|229333546, gi... - gi\|229529772\|ref\|ZP_04419162.1\| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase...	287.0	[0..6]	[203..10]
tr\|D7H7Y7\|D7H7Y7... - Histidine biosynthesis bifunctional protein HisIE OS=Vibrio cholerae RC385 GN=hisI PE=3 SV=1 gi\|254223617, gi... - gi\|75823475\|ref\|ZP_00752973.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Vibrio cholerae RC385], g...	286.0	[0..6]	[203..10]
gi\|75196093, gi\|... - gi\|75196093\|ref\|ZP_00706163.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Escherichia coli HS], gi\|...	286.0	[0..1]	[202..1]
gi\|77962466 - gi\|77962466\|ref\|ZP_00826286.1\| COG0139: Phosphoribosyl-AMP cyclohydrolase [Yersinia mollaretii ATCC ...	285.0	[0..1]	[203..1]
HIS2_CALS4 - Histidine biosynthesis bifunctional protein HisIE OS=Caldanaerobacter subterraneus subsp. tengcongen... HIS2_THETN - Histidine biosynthesis bifunctional protein hisIE OS=Thermoanaerobacter tengcongensis GN=hisI PE=3 S...	281.0	[0..1]	[203..1]
HIS2_KLEPN - Histidine biosynthesis bifunctional protein HisIE OS=Klebsiella pneumoniae GN=hisI PE=3 SV=1 gi\|206577073, gi... - gi\|206577073\|ref\|YP_002237534.1\| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase ...	281.0	[0..1]	[202..1]

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Predicted Domain #1

Region A:
Residues: [1-108]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTEQQRREL DWEKTDGLMP VIVQHAVSGE VLMLGYMNPE ALDKTLESGK VTFFSRTKQR  60
   61 LWTKGETSGN FLNVVSIAPD CDNDTLLVLA NPIGPTCHKG TSSCFGDT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.39794
Match:	1zpsA
Description:	Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [109-203]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AHQWLFLYQL EQLLAERKSA DPETSYTAKL YASGTKRIAQ KVGEEGVETA LAATVHDRFE  60
   61 LTNEASDLMY HLLVLLQDQG LDLTTVIENL RKRHQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.154902
Match:	1yvwA
Description:	Crystal structure of Phosphoribosyl-ATP pyrophosphohydrolase from Bacillus cereus. NESGC target BcR13.
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits