YRC Public Data Repository - Protein Structure Prediction

Protein:	HEMX_ECOLI
Organism:	Escherichia coli
Length:	393 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEMX_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|81243167, gi\|... - gi\|82779019\|ref\|YP_405368.1\| putative uroporphyrinogen III C-methyltransferase [Shigella dysenteriae...	335.0	[0..1]	[393..1]
gi\|77633325 - gi\|77633325\|ref\|ZP_00795462.1\| COG2959: Uncharacterized enzyme of heme biosynthesis [Yersinia pestis... gi\|77630749, gi\|... - gi\|77630749\|ref\|ZP_00793335.1\| COG2959: Uncharacterized enzyme of heme biosynthesis [Yersinia pseudo... gi\|21957065, gi\|... - gi\|22124294\|ref\|NP_667717.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pestis KIM]... gi\|167401808, gi... - gi\|167401808\|ref\|ZP_02307296.1\| putative uroporphyrinogen III methylase [Yersinia pestis biovar Anti... gi\|45442947, gi\|... - gi\|45442947\|ref\|NP_994486.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pestis biov...	332.0	[0..1]	[375..4]
gi\|157068956, gi... - gi\|75197686\|ref\|ZP_00707756.1\| COG2959: Uncharacterized enzyme of heme biosynthesis [Escherichia col...	332.0	[0..1]	[393..1]
gi\|162418964, gi... - gi\|162418964\|ref\|YP_001605127.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pestis ... gi\|165926352, gi... - gi\|165926352\|ref\|ZP_02222184.1\| putative uroporphyrinogen III methylase [Yersinia pestis biovar Orie... gi\|165939114, gi... - gi\|165939114\|ref\|ZP_02227665.1\| putative uroporphyrinogen III methylase [Yersinia pestis biovar Orie... gi\|165989458, gi... - gi\|166011689\|ref\|ZP_02232587.1\| putative uroporphyrinogen III methylase [Yersinia pestis biovar Anti... gi\|145600719, gi... - gi\|145600719\|ref\|YP_001164795.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pestis ... gi\|25511299 - pir\|\|AC0469 probable uroporphyrin-III C-methyltransferase hemX [imported] - Yersinia pestis (strain ... gi\|229682466, gi... - gi\|229900447\|ref\|ZP_04515576.1\| predicted uroporphyrinogen III methylase [Yersinia pestis Nepal516],... gi\|170026229, gi... - gi\|170026229\|ref\|YP_001722734.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pseudot... gi\|108806168, gi... - gi\|108806168\|ref\|YP_650084.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pestis Ant... gi\|229706127, gi... - gi\|229837184\|ref\|ZP_04457349.1\| predicted uroporphyrinogen III methylase [Yersinia pestis Pestoides ... gi\|115349465, gi... - gi\|218930854\|ref\|YP_002348729.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pestis ... gi\|166213622, gi... - gi\|166213622\|ref\|ZP_02239657.1\| putative uroporphyrinogen III methylase [Yersinia pestis biovar Anti... gi\|167420871, gi... - gi\|167420871\|ref\|ZP_02312624.1\| putative uroporphyrinogen III methylase [Yersinia pestis biovar Orie... gi\|153997093, gi... - gi\|153997093\|ref\|ZP_02022226.1\| putative uroporphyrin-III C-methyltransferase [Yersinia pestis CA88-... gi\|167054823, gi... - gi\|167426304\|ref\|ZP_02318057.1\| putative uroporphyrinogen III methylase [Yersinia pestis biovar Medi... gi\|229695910, gi... - gi\|229839544\|ref\|ZP_04459703.1\| predicted uroporphyrinogen III methylase [Yersinia pestis biovar Ori... gi\|153946970, gi... - gi\|153946970\|ref\|YP_001399193.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pseudot... gi\|167470635 - gi\|167470635\|ref\|ZP_02335339.1\| putative uroporphyrinogen III methylase [Yersinia pestis FV-1] gi\|229900107, gi... - gi\|229900107\|ref\|ZP_04515244.1\| predicted uroporphyrinogen III methylase [Yersinia pestis biovar Ori...	330.0	[0..1]	[375..1]
gi\|51587820, gi\|... - gi\|51594538\|ref\|YP_068729.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pseudotuber... gi\|186893536, gi... - gi\|186893536\|ref\|YP_001870648.1\| putative uroporphyrinogen III C-methyltransferase [Yersinia pseudot... Q66G02\|Q66G02_YERPS - Putative uroporphyrin-III C-methyltransferase - Yersinia pseudotuberculosis	329.0	[0..1]	[375..1]
gi\|124499225, gi... - gi\|124530459\|ref\|ZP_01701117.1\| protein of unknown function DUF513, hemX [Escherichia coli B], gi\|12... gi\|169757102, gi... - gi\|170022174\|ref\|YP_001727128.1\| putative uroporphyrinogen III C-methyltransferase [Escherichia coli... gi\|157079293, gi... - gi\|75188545\|ref\|ZP_00701812.1\| COG2959: Uncharacterized enzyme of heme biosynthesis [Escherichia col...	322.0	[0..1]	[393..1]
gi\|30043164, gi\|... - gi\|30064904\|ref\|NP_839075.1\| putative uroporphyrinogen III C-methyltransferase [Shigella flexneri 2a...	321.0	[0..1]	[393..1]
gi\|89101533 - gi\|89101533\|ref\|ZP_01174273.1\| COG2959: Uncharacterized enzyme of heme biosynthesis [Yersinia pestis...	320.0	[0..9]	[375..1]
gi\|75512638, gi\|... - gi\|75512638\|ref\|ZP_00735150.1\| COG2959: Uncharacterized enzyme of heme biosynthesis [Escherichia col...	320.0	[0..1]	[393..1]
gi\|75230764, gi\|... - gi\|75230764\|ref\|ZP_00717227.1\| COG2959: Uncharacterized enzyme of heme biosynthesis [Escherichia col...	319.0	[0..1]	[393..1]

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Predicted Domain #1

Region A:
Residues: [1-126]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEQEKTSAV VEETREAVDT TSQPVATEKK SKNNTALILS AVAIAIALAA GIGLYGWGKQ  60
   61 QAVNQTATSD ALANQLTALQ KAQESQKAEL EGIIKQQAAQ LKQANRQQET LAKQLDEVQQ 120
  121 KVATIS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.0
Match:	2i1jA
Description:	No description for 2i1jA was found.

Predicted Domain #2

Region A:
Residues: [127-237]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSDAKTWLLA QADFLVKLAG RKLWSDQDVT TAAALLKSAD ASLADMNDPS LITVRRAITD  60
   61 DIASLSAVSQ VDYDGIILKL NQLSNQVDNL RLADNDSDGS PMDSDGEELS S

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [238-393]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SISEWRINLQ KSWQNFMDNF ITIRRRDDTA VPLLAPNQDI YLRENIRSRL LVAAQAVPRH  60
   61 QEETYRQALE NVSTWVRAYY DTDDATTKAF LDEVDQLSQQ NISMDLPETL QSQAMLEKLM 120
  121 QTRVRNLLAQ PAAGTTEAKP APAPQADTPA AAPQGE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits