YRC Public Data Repository - Protein Structure Prediction

Protein:	HEM4_ECOLI
Organism:	Escherichia coli
Length:	246 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEM4_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|71489436, gi\|... - gi\|71544542\|ref\|ZP_00665566.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Syntrophobacter fum...	242.0	[0..2]	[245..255]
gi\|147677308, gi... - gi\|98661630\|dbj\|GAA01338.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476773...	240.0	[0..2]	[245..256]
gi\|118581774, gi... - gi\|71836333\|ref\|ZP_00676102.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Pelobacter propioni...	238.0	[0..2]	[246..259]
gi\|50123109, gi\|... - gi\|50123109\|ref\|YP_052276.1\| uroporphyrinogen-III synthase [Pectobacterium atrosepticum SCRI1043], g...	237.0	[0..1]	[246..1]
gi\|48845542, gi\|... - gi\|78224426\|ref\|YP_386173.1\| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...	236.0	[0..2]	[245..261]
gi\|51245586, gi\|... - gi\|51245586\|ref\|YP_065470.1\| uroporphyrinogen III synthase/methyltransferase (HemD+CobA) [Desulfotal...	236.0	[0..2]	[245..264]
gi\|94730811, gi\|... - gi\|94986562\|ref\|YP_594495.1\| siroheme synthase [Lawsonia intracellularis PHE/MN1-00], gi\|94730811\|em...	236.0	[0..2]	[245..254]
gi\|88945102, gi\|... - gi\|88945102\|ref\|ZP_01148322.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfotomaculum re...	235.0	[0..2]	[245..258]
gi\|84780865, gi\|... - gi\|85060345\|ref\|YP_456047.1\| uroporphyrinogen-III synthase [Sodalis glossinidius str. 'morsitans'], ...	233.0	[0..1]	[245..1]
gi\|77959977 - gi\|77959977\|ref\|ZP_00823884.1\| COG1587: Uroporphyrinogen-III synthase [Yersinia mollaretii ATCC 4396...	231.0	[0..1]	[246..1]

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Predicted Domain #1

Region A:
Residues: [1-246]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSILVTRPSP AGEELVSRLR TLGQVAWHFP LIEFSPGQQL PQLADQLAAL GESDLLFALS  60
   61 QHAVAFAQSQ LHQQDRKWPR LPDYFAIGRT TALALHTVSG QKILYPQDRE ISEVLLQLPE 120
  121 LQNIAGKRAL ILRGNGGREL IGDTLTARGA EVTFCECYQR CAIHYDGAEE AMRWQAREVT 180
  181 MVVVTSGEML QQLWSLIPQW YREHWLLHCR LLVVSERLAK LARELGWQDI KVADNADNDA 240
  241 LLRALQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.39794
Match:	1jr2A
Description:	Uroporphyrinogen III synthase (U3S, HemD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrinogen-III synthase activity	3.19339392327514	bayes_pls_golite062009
catalytic activity	1.50868196926865	bayes_pls_golite062009
hydro-lyase activity	0.850411184249311	bayes_pls_golite062009
lyase activity	0.0536528882085157	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: