YRC Public Data Repository - Protein Structure Prediction

Protein:	HCR_ECOLI
Organism:	Escherichia coli
Length:	322 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HCR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|254229090, gi... - gi\|75856649\|ref\|ZP_00764274.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1...	267.0	[0..3]	[321..273]
gi\|91223364, gi\|... - gi\|91223364\|ref\|ZP_01258630.1\| hypothetical protein V12G01_05956 [Vibrio alginolyticus 12G01], gi\|91...	266.0	[0..3]	[321..273]
gi\|27367941, gi\|... - gi\|27367941\|ref\|NP_763468.1\| flavodoxin reductase family 1 protein [Vibrio vulnificus CMCP6], gi\|273...	265.0	[0..10]	[319..280]
gi\|89076140, gi\|... - gi\|89076140\|ref\|ZP_01162498.1\| hypothetical protein SKA34_09198 [Photobacterium sp. SKA34], gi\|89048...	264.0	[0..3]	[321..277]
gi\|28900266, gi\|... - gi\|28900266\|ref\|NP_799921.1\| hypothetical protein VPA0411 [Vibrio parahaemolyticus RIMD 2210633], gi... gi\|28808577 - gi\|28808577\|dbj\|BAC61754.1\| conserved hypothetical protein [Vibrio parahaemolyticus RIMD 2210633]	263.0	[0..5]	[321..275]
gi\|90578294, gi\|... - gi\|90578294\|ref\|ZP_01234105.1\| hypothetical protein VAS14_14624 [Vibrio angustum S14], gi\|90441380\|g...	263.0	[0..3]	[321..277]
gi\|37200609, gi\|... - gi\|37676069\|ref\|NP_936465.1\| flavodoxin reductase (ferredoxin-NADPH reductase) family protein 1 [Vib...	263.0	[0..10]	[319..326]
gi\|110614420, gi... - gi\|110804872\|ref\|YP_688392.1\| HCP oxidoreductase, NADH-dependent [Shigella flexneri 5 str. 8401], gi...	257.0	[0..1]	[322..1]
gi\|226898374, gi... - gi\|237707164\|ref\|ZP_04537645.1\| NADH oxidoreductase hcr [Escherichia sp. 3_2_53FAA], gi\|226898374\|gb... gi\|117623051, gi... - gi\|117623051\|ref\|YP_851964.1\| HCP oxidoreductase, NADH-dependent [Escherichia coli APEC O1], gi\|1155... gi\|110342665, gi... - gi\|110641073\|ref\|YP_668803.1\| HCP oxidoreductase, NADH-dependent [Escherichia coli 536], gi\|11034266... gi\|191172087, gi... - gi\|191172087\|ref\|ZP_03033631.1\| NADH oxidoreductase hcr [Escherichia coli F11], gi\|190907614\|gb\|EDV6... gi\|218364544, gi... - gi\|218557775\|ref\|YP_002390688.1\| HCP oxidoreductase, NADH-dependent [Escherichia coli S88], gi\|21836...	256.0	[0..1]	[322..1]
gi\|91071480, gi\|... - gi\|91209906\|ref\|YP_539892.1\| HCP oxidoreductase, NADH-dependent [Escherichia coli UTI89], gi\|9107148...	256.0	[0..1]	[322..3]

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Predicted Domain #1

Region A:
Residues: [1-322]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMPTNQCPW RMQVHHITQE TPDVWTISLI CHDYYPYRAG QYALVSVRNS AETLRAYTIS  60
   61 STPGVSEYIT LTVRRIDDGV GSQWLTRDVK RGDYLWLSDA MGEFTCDDKA EDKFLLLAAG 120
  121 CGVTPIMSMR RWLAKNRPQA DVRVIYNVRT PQDVIFADEW RNYPVTLVAE NNVTEGFIAG 180
  181 RLTRELLAGV PDLASRTVMT CGPAPYMDWV EQEVKALGVT RFFKEKFFTP VAEAATSGLK 240
  241 FTKLQPAREF YAPVGTTLLE ALESNNVPVV AACRAGVCGC CKTKVVSGEY TVSSTMTLTD 300
  301 AEIAEGYVLA CSCHPQGDLV LA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.09691
Match:	2piaA
Description:	PHTHALATE DIOXYGENASE REDUCTASE: A MODULAR STRUCTURE FOR ELECTRON TRANSFER FROM PYRIDINE NUCLEOTIDES TO [2FE-2S]
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.475559813757564	bayes_pls_golite062009
transferase activity	0.20565726169867	bayes_pls_golite062009
oxidoreductase activity	0.20476078875772	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: