YRC Public Data Repository - Protein Structure Prediction

Protein:	GLPB_ECOLI
Organism:	Escherichia coli
Length:	419 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLPB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|86135035, gi\|... - gi\|86135035\|ref\|ZP_01053617.1\| dihydrolipoamide dehydrogenase [Polaribacter sp. MED152], gi\|85821898...	226.0	[0..1]	[415..20]
gi\|71062053, gi\|... - gi\|71082940\|ref\|YP_265659.1\| dihydrolipoyl dehydrogenase [Candidatus Pelagibacter ubique HTCC1062], ...	223.0	[0..2]	[416..4]
gi\|91762636, gi\|... - gi\|91762636\|ref\|ZP_01264601.1\| Dihydrolipoyl dehydrogenase [Candidatus Pelagibacter ubique HTCC1002]...	223.0	[0..2]	[416..4]
gi\|88782028, gi\|... - gi\|88801370\|ref\|ZP_01116898.1\| Pyruvate/2-oxoglutarate dehydrogenase complex [Polaribacter irgensii ...	221.0	[0..1]	[415..1]
gi\|88713490, gi\|... - gi\|88713490\|ref\|ZP_01107572.1\| Dihydrolipoyl dehydrogenase [Flavobacteriales bacterium HTCC2170], gi...	221.0	[0..2]	[415..3]
gi\|68193504, gi\|... - gi\|69275064\|ref\|ZP_00610976.1\| Dihydrolipoamide dehydrogenase [Mesorhizobium sp. BNC1], gi\|68193504\|...	220.0	[0..3]	[416..5]
gi\|83850465, gi\|... - gi\|83856665\|ref\|ZP_00950194.1\| Dihydrolipoyl dehydrogenase [Croceibacter atlanticus HTCC2559], gi\|83...	220.0	[0..2]	[415..3]
gi\|90106007, gi\|... - gi\|90423993\|ref\|YP_532363.1\| dihydrolipoamide dehydrogenase [Rhodopseudomonas palustris BisB18], gi\|...	219.0	[0..3]	[405..6]
gi\|22652790 - gi\|22652790\|gb\|AAN03817.1\|AF497852_3 dihydrolipoamide dehydrogenase [Methylobacterium extorquens] gi\|240008178, gi... - gi\|240138209\|ref\|YP_002962681.1\| dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of th... gi\|218522208, gi... - gi\|218529905\|ref\|YP_002420721.1\| dihydrolipoamide dehydrogenase [Methylobacterium chloromethanicum C...	219.0	[0..1]	[416..1]
gi\|49238177, gi\|... - gi\|49475371\|ref\|YP_033412.1\| dihydrolipoamide dehydrogenase [Bartonella henselae str. Houston-1], gi...	219.0	[0..3]	[411..5]

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Predicted Domain #1

Region A:
Residues: [1-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFDTVIMGG GLAGLLCGLQ LQKHGLRCAI VTRGQSALHF SSGSLDLLSH LPDGQPVTDI  60
   61 HSGLESLRQQ APAHPYSLLE PQRVLDLACQ AQALIAESGA QLQGSVELAH QRVTPLGTLR 120
  121 STWLSSPEVP VWPLPAKKIC VVGISGLMDF QAHLAAASLR ELGLAVETAE IELPELDVLR 180
  181 NNATEFRAVN IARFLDNEEN WPLLLDALIP VANTCEMILM PACFGLADDK LWRWLNEKLP 240
  241 CSLMLLPTLP PSVLGIRLQN QLQRQFVRQG GVWMPGDEVK KVTCKNGVVN EIWTRNHADI 300
  301 PLRPRFAVLA SGSFFSGGLV AERNGIREPI LGLDVLQTAT RGEWYKGDFF APQPWQQFGV 360
  361 TTDETLRPSQ AGQTIENLFA IGSVLGGFDP IAQGCGGGVC AVSALHAAQQ IAQRAGGQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.39794
Match:	1lpfA
Description:	Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	2.84234192551392	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	2.35054457932442	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.14701726867934	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.960204355303275	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	0.7514316327505	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: