YRC Public Data Repository - Protein Structure Prediction

Protein:	FDNH_ECOLI
Organism:	Escherichia coli
Length:	294 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FDNH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|209770712, gi... - pir\|\|G90888 hypothetical protein ECs2079 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|15801662, gi\|... - gi\|15801662\|ref\|NP_287680.1\| formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit [E... gi\|13361545, gi\|... - gi\|15831333\|ref\|NP_310106.1\| nitrate-inducible formate dehydrogenase-N iron-sulfur beta subunit [Esc... gi\|13361545, gi\|... - gi\|15831333\|ref\|NP_310106.1\| nitrate-inducible formate dehydrogenase-N iron-sulfur beta subunit [Esc... gi\|195936968 - gi\|195936968\|ref\|ZP_03082350.1\| nitrate-inducible formate dehydrogenase-N iron-sulfur beta subunit [... gi\|208741300, gi... - gi\|208821177\|ref\|ZP_03261497.1\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche... gi\|217329329, gi... - gi\|217329329\|ref\|ZP_03445409.1\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche... gi\|189361862, gi... - gi\|189403196\|ref\|ZP_02793994.2\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche... gi\|189368151, gi... - gi\|189403981\|ref\|ZP_02786435.2\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche... gi\|189405135, gi... - gi\|189405135\|ref\|ZP_02813472.2\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche... gi\|189378144, gi... - gi\|189405819\|ref\|ZP_02824398.2\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche... gi\|187770131, gi... - gi\|187775942\|ref\|ZP_02799296.2\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche... gi\|188024780, gi... - gi\|188024780\|ref\|ZP_02773941.2\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche... gi\|254592421, gi... - gi\|254793021\|ref\|YP_003077858.1\| formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible [Es... gi\|189000803, gi... - gi\|189010339\|ref\|ZP_02806460.2\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche... gi\|189356680, gi... - gi\|189402246\|ref\|ZP_02781130.2\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esche...	286.0	[0..1]	[294..1]
gi\|187730732, gi... - gi\|75178552\|ref\|ZP_00698598.1\| COG0437: Fe-S-cluster-containing hydrogenase components 1 [Shigella b...	286.0	[0..1]	[294..1]
gi\|251784954, gi... - gi\|251784954\|ref\|YP_002999258.1\| hypothetical protein B21_01445 [Escherichia coli BL21], gi\|24237722... gi\|83587814, gi\|... - gi\|83587814\|ref\|ZP_00926440.1\| COG0437: Fe-S-cluster-containing hydrogenase components 1 [Escherichi... gi\|253973434, gi... - gi\|254161533\|ref\|YP_003044641.1\| formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible [Es... gi\|254288338, gi... - gi\|254288338\|ref\|YP_003054086.1\| formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible [Es...	285.0	[0..1]	[294..1]
gi\|83570858, gi\|... - gi\|83570858\|ref\|ZP_00922300.1\| COG0437: Fe-S-cluster-containing hydrogenase components 1 [Shigella d...	285.0	[0..1]	[294..1]
gi\|170681880, gi... - gi\|170681880\|ref\|YP_001743753.1\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Esch... gi\|218370091, gi... - gi\|218700105\|ref\|YP_002407734.1\| formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible [Es... gi\|75240179, gi\|... - gi\|75240179\|ref\|ZP_00724131.1\| COG0437: Fe-S-cluster-containing hydrogenase components 1 [Escherichi...	284.0	[0..1]	[294..1]
gi\|227836890, gi... - gi\|227886133\|ref\|ZP_04003938.1\| formate dehydrogenase-N beta subunit [Escherichia coli 83972], gi\|22... gi\|215264773, gi... - gi\|215486701\|ref\|YP_002329132.1\| formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible [Es... gi\|237705452, gi... - gi\|237705452\|ref\|ZP_04535933.1\| formate dehydrogenase-N beta subunit [Escherichia sp. 3_2_53FAA], gi... gi\|218365166, gi... - gi\|218558397\|ref\|YP_002391310.1\| formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible [Es... gi\|91210714, gi\|... - gi\|91210714\|ref\|YP_540700.1\| formate dehydrogenase-N beta subunit [Escherichia coli UTI89], gi\|91072... gi\|26247763, gi\|... - gi\|26247763\|ref\|NP_753803.1\| formate dehydrogenase-N beta subunit [Escherichia coli CFT073], gi\|2610... gi\|218689395, gi... - gi\|218689395\|ref\|YP_002397607.1\| formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible [Es...	283.0	[0..1]	[294..1]
gi\|74312159, gi\|... - gi\|74312159\|ref\|YP_310578.1\| formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit [S...	283.0	[0..1]	[294..1]
gi\|81241022, gi\|... - gi\|82776874\|ref\|YP_403223.1\| formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit [S...	283.0	[0..1]	[293..1]
gi\|37528694, gi\|... - gi\|37528694\|ref\|NP_932039.1\| formate dehydrogenase-O, iron-sulfur subunit (formate dehydrogenase-O b...	281.0	[0..1]	[293..1]
gi\|110641654, gi... - gi\|110641654\|ref\|YP_669384.1\| formate dehydrogenase, nitrate-inducible, iron-sulfur subunit [Escheri...	281.0	[0..3]	[294..1]

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Predicted Domain #1

Region A:
Residues: [1-294]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMETQDIIK RSATNSITPP SQVRDYKAEV AKLIDVSTCI GCKACQVACS EWNDIRDEVG  60
   61 HCVGVYDNPA DLSAKSWTVM RFSETEQNGK LEWLIRKDGC MHCEDPGCLK ACPSAGAIIQ 120
  121 YANGIVDFQS ENCIGCGYCI AGCPFNIPRL NKEDNRVYKC TLCVDRVSVG QEPACVKTCP 180
  181 TGAIHFGTKK EMLELAEQRV AKLKARGYEH AGVYNPEGVG GTHVMYVLHH ADQPELYHGL 240
  241 PKDPKIDTSV SLWKGALKPL AAAGFIATFA GLIFHYIGIG PNKEVDDDEE DHHE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.39794
Match:	1kqfB
Description:	Formate dehydrogenase N, iron-sulfur (beta) subunit; Iron-sulfur subunit of formate dehydrogenase N, transmembrane anchor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
formate dehydrogenase activity	10.9674358961972	bayes_pls_golite062009
oxidoreductase activity	5.98361135786786	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	5.77927347135001	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	5.39747453448396	bayes_pls_golite062009
electron carrier activity	5.05393703018095	bayes_pls_golite062009
NADH dehydrogenase activity	3.13953145151561	bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity	2.76338281383262	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	2.70037803782769	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	2.09041948600744	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.80621486978907	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	1.5619384041388	bayes_pls_golite062009
iron-sulfur cluster binding	1.30496569995148	bayes_pls_golite062009
metal cluster binding	1.30496569995148	bayes_pls_golite062009
catalytic activity	0.488483980994331	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: